A5101740674- Transition Metal Oxide Nanomaterials
- T-cell and Retrovirus Studies
- Gas Sensing Nanomaterials and Sensors
- Hydrogels: synthesis, properties, applications
- Fungal Biology and Applications
- Signaling Pathways in Disease
- Vector-Borne Animal Diseases
- Microbial Natural Products and Biosynthesis
- Animal Disease Management and Epidemiology
- Bioactive Compounds and Antitumor Agents
- Supercapacitor Materials and Fabrication
- Research on Leishmaniasis Studies
- Advanced Sensor and Energy Harvesting Materials
- Conducting polymers and applications
- Advanced Theoretical and Applied Studies in Material Sciences and Geometry
- Material Properties and Applications
- Cancer Cells and Metastasis
- Advanced battery technologies research
- Cancer Treatment and Pharmacology
- Slime Mold and Myxomycetes Research
- Biocrusts and Microbial Ecology
- Polymer Nanocomposites and Properties
- Advanced Polymer Synthesis and Characterization
- Synthesis of Tetrazole Derivatives
- Freezing and Crystallization Processes
Gumma Paz College
2012-2025
St. Marianna University School of Medicine
2010-2024
Kyoto University
1997-2024
BioScience Laboratories (United States)
2024
National Center for Global Health and Medicine
2024
Kanazawa University
2018
Tokyo Institute of Technology
1989-2016
The University of Tokyo
2013
Gunma University
2004-2011
University of Washington
2004-2005
Abstract This article summarizes our most recent studies on improved Li + ‐intercalation properties in vanadium oxides by engineering the nanostructure and interlayer structure. The intercalation capacity rate are enhanced almost two orders of magnitude with appropriately fabricated nanostructures. Processing methods for single‐crystal V 2 O 5 nanorod arrays, · n H nanotube Ni/V core/shell nanocable arrays presented; morphologies, structures, growth mechanisms these nanostructures discussed....
This paper reports a study on template-growth and electrochemical properties of single-crystal vanadium pentoxide (V2O5) nanorod arrays from VOSO4 aqueous solution using deposition. Uniformly sized oxide nanorods with length about 10 μm diameters ranging 100 to 200 nm were grown over large area near unidirectional alignment. These have single-crystalline structure growth direction [010]. Electrochemical property analysis indicates that array electrodes significantly higher current density...
Human T-lymphotropic virus type 1 (HTLV-1) is linked to multiple diseases, including the neuroinflammatory disease HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T cell leukemia/lymphoma. Evidence suggests that HTLV-1, via viral protein Tax, exploits CD4+ plasticity induces transcriptional changes in infected cells cause suppressive CD4+CD25+CCR4+ Tregs lose expression of transcription factor FOXP3 produce IFN-γ, thus promoting inflammation. We hypothesized...
This paper reports a study on the template-based growth and electrochromic properties of single-crystal vanadium pentoxide nanorod arrays by sol electrophoretic deposition. The formation nanorods is attributed to homoepitaxial aggregation nanoparticles. Nanorod have demonstrated significantly enhanced properties; both larger change transmittance intensity more rapid response upon applying external electric field are large surface volume ratio improved transport kinetics for electrochemical...
Background Human T-lymphotropic virus type-1 (HTLV-1) is a human retrovirus that causes HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukaemia (ATL). A higher viral load in individuals with HTLV-1 infection increases their risk of developing HAM/TSP ATL. Moreover, the high proviral associated clinical progression HAM/TSP. Reduction number HTLV-1-infected cells therefore crucial for preventing treating diseases. Recently, fucoidan, complex sulphated...
Corticosteroids are most commonly used to treat HTLV-1-associated myelopathy (HAM); however, their clinical efficacy has not been tested in randomized trials. This controlled trial included 8 and 30 HAM patients with rapidly slowly progressing walking disabilities, respectively. Rapid progressors were assigned (1:1) receive or a 3-day course of intravenous methylprednisolone addition oral prednisolone therapy. Meanwhile, slow placebo. The primary outcomes composite ≥1-grade improvement the...
Dictyostelium differentiation-inducing factors 1 and 3 [DIF-1 (1) DIF-3 (2), respectively], along with their derivatives, such as Ph-DIF-1 (3) Bu-DIF-3 (4), demonstrate antibacterial activity in vitro against Gram-positive bacteria, including methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant S. (MRSA), vancomycin-sensitive Enterococcus faecalis (VSE), vancomycin-resistant faecium [VRE (VanA)]. This study investigates the therapeutic potential of DIF compounds these...
Growth and electrochemical properties of single-crystalline vanadium pentoxide (V 2 O 5 ) nanorod arrays were investigated. Vanadium grown by deposition, surface condensation induced a pH change sol electrophoretic deposition. Uniformly sized oxide nanorods with length about 10 µm diameters 100 or 200 nm over large area near-unidirectional alignment. Transmission electron microscopy (TEM) micrographs diffraction patterns V clearly show the nature fabricated via all three growth routes...
Human T-lymphotropic virus type 1 (HTLV-1) can cause chronic spinal cord inflammation, known as HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP). Since CD4+CCR4+ T cells are the main HTLV-1 reservoir, we evaluated defucosylated humanized anti-CCR4 antibody mogamulizumab a treatment for HAM/TSP. We assessed effects of on peripheral blood mononuclear from 11 patients with also studied how CD8+ cells, namely CCR4+ and cytotoxic lymphocytes, involved in infection HAM/TSP...
Background Human T-cell leukemia virus type 1 (HTLV-1) causes HTLV-1-associated myelopathy (HAM), adult leukemia/lymphoma (ATL), uveitis, and pulmonary diseases. Although both HAM ATL show proliferation of infected cells, their pathogeneses are quite different. In particular, the pathogenesis is characterized by hyperimmune responses to HTLV-1-infected cells. Recently, we demonstrated overexpression histone methyltransferase EZH2 in cells cytotoxic effects inhibitors EZH1/2 dual on these...
Abstract The differentiation-inducing factor-1 (DIF-1) isolated from Dictyostelium discoideum is a potent antiproliferative agent that induces growth arrest and differentiation in mammalian cells vitro. However, the specific target molecule(s) of DIF-1 has not been identified. In this study, we have tried to identify cells, examining effects its analogs on activity some candidate enzymes. at 10–40 μm dose-dependently suppressed cell increased intracellular cyclic AMP concentration K562...
Swelling and deswelling kinetics was investigated for three types of cylindrical poly(N-isopropylacrylamide) (PNIPA) gels differing in crosslink density. The temperature dependence curves the volume gel specimens were different from one another. One considered as a critical showing continuous phase transition. change process after jump examined. In processes with jumps to temperatures higher than 35 degrees C, separation observed slowed down due homogenization separation. value diffusion...
The effects of mechanical stress on the volume phase transition a poly(N-isopropylacrylamide) (PNIPA) gel as well copolymer composed N-isopropylacrylamide (NIPA) and sodium acrylate (SA) were investigated in relatively low region. PNIPA without elongational showed behavior close to second order transition. character first became clear under tension, temperature increased with increasing applied stress. Similar was observed for NIPA-SA gel, but whole range investigated. thermodynamical linear...
Eight chlorinated alkylresorcinols, monochasiol A–H (1–8), were isolated from the fruiting bodies of Dictyostelium monochasioides. Compounds 1–8 synthesized to confirm their structures and obtain sufficient material for performing biological tests. Monochasiol A (1) selectively inhibited concanavalin A-induced interleukin-2 production in Jurkat cells, a human T lymphocyte cell line. Monochasiols biogenetically by combination biosynthetic enzymes relating principal polyketides, MPBD DIF-1,...
Distinguishing human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy from hereditary spastic paraplegia in patients infected with HTLV-1 is challenging due to overlapping clinical symptoms. The aim of this study was explore the possibility that inherently present diagnosed HTLV-1-associated myelopathy.
Differentiation-inducing factor-3 (DIF-3; 1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one), which is found in the cellular slime mold Dictyostelium discoideum, a potential candidate compound for development of new medicines; DIF-3 and its derivatives possess several beneficial biological activities, including anti-tumor, anti-Trypanosoma cruzi, immunoregulatory effects. To assess relationship between activities chemical structure, particularly regard to alkoxy group length alkyl chains...
Triple-negative breast cancer (TNBC) is highly proliferative and metastatic, because it lacks three major molecular targets for chemotherapy (estrogen receptor, progesterone human epidermal receptor 2), extremely refractory. Differentiation-inducing factor 1 (DIF-1) DIF-3, which are chlorinated alkylphenones, lead anticancer compounds found in the cellular slime mold Dictyostelium discoideum. Here, we examined vitro effects of DIF-1, 25 DIF derivatives on cell proliferation serum-induced...