A5047129286- Ovarian cancer diagnosis and treatment
- Pelvic floor disorders treatments
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
- Cervical Cancer and HPV Research
- Reproductive System and Pregnancy
- Prenatal Screening and Diagnostics
- Anorectal Disease Treatments and Outcomes
- Reproductive Biology and Fertility
- Maternal and Perinatal Health Interventions
- Extracellular vesicles in disease
- Endometriosis Research and Treatment
- Pelvic and Acetabular Injuries
- Maternal and fetal healthcare
- Intraperitoneal and Appendiceal Malignancies
- Preterm Birth and Chorioamnionitis
- Gestational Trophoblastic Disease Studies
- Endometrial and Cervical Cancer Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Anesthesia and Pain Management
- Parvovirus B19 Infection Studies
- Ovarian function and disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital limb and hand anomalies
- Infant Nutrition and Health
University of L'Aquila
2010-2019
San Salvatore Hospital
1999-2019
Azienda Ospedaliero-Universitaria Careggi
2017
Federación Colombiana de Obstetricia y Ginecología
2003
University of Cagliari
2000
Matrix metalloproteinase (MMP) degradation of extracellular matrix is thought to play an important role in invasion, angiogenesis, tumor growth, and metastasis. Several studies have demonstrated that CD147/ MMP inducer, a membrane-spanning molecule highly expressed cells, may be involved the progression malignancies by regulating expression peritumoral stromal cells. In present study we show CD147 microvesicles derived from epithelial ovarian cancer cells CD147-positive vesicles promote...
Vesicles shed by cancer cells are known to mediate several tumor-host interactions. Tumor microenvironment may, in turn, influence the release and activity of tumor-shed microvesicles. In this study, we investigated molecular mediators pH-dependent proinvasive vesicles. Gelatinase zymography showed increased microvesicle matrix metalloproteinases 9 2 as a result acid exposure (pH 5.6) compared pH 7.4. Thus, reasoned that cysteine protease cathepsin B might play role mediating activation...
It has become clear that non-tumor cells in the microenvironment, especially fibroblasts, actively participate tumor progression. Fibroblasts conditioned by "activated" and, as such, are identified CAFs (cancer-associated fibroblasts). These remodel stroma to make it more favourable for cancer The aim of this work was verify whether EVs (extracellular vesicles - whose role mediators information between and stromal is well known) released from human ovarian were able activate fibroblasts....
Cancer therapies are associated with increased infertility risk due to accelerated reproductive aging. Oxidative stress (OS) is a potential mechanism behind ovarian toxicity by cyclophosphamide (CPM), the most ovotoxic anticancer drug. An important sensor of OS SIRT1, NAD + ‐dependent deacetylase which regulates cellular defence and cell fate. This study investigated whether natural carotenoid crocetin synthetic compound AS101 protect ovary against CPM modulating SIRT1 mitochondrial markers....
Platelet gel is used to facilitate wound healing in virtue of the growth factors released from activated platelets at site lesion, but little known about specific mechanisms underlying cellular repair.To evaluate, vitro, effects different concentrations platelet -released supernatant on endothelial cells.Platelet concentrate was produced Service Immunohaematology and Transfusion San Salvatore Hospital L'Aquila, using multiple bags. obtained by adding thrombin calcium gluconate concentrates...
The objective of this study was to evaluate the morphological and immunohistochemical alterations tissue removed from upper third anterior vaginal wall in a sample group female population presenting homogenous risk factors associated with Pelvic Organ Prolapse (POP). case consisted 14 patients POP there were 10 control group. Patient selection carried on basis specific criteria all involved presented one or more recognized factors. Samples taken during plastic surgery following Â...
1. The systemic administration of Delta(9)-tetrahydrocannabinol (2.5 - 7.5 mg kg(-1)) reduced hippocampal extracellular acetylcholine concentration and impaired working memory in rats. 2. Both effects were antagonized not only by the CB(1) cannabinoid receptor antagonist SR141716A (0.5 kg(-1), i.p.) but also unexpectedly D(2) dopamine S(-)-sulpiride (5, 10 25 i.p.). Conversely, Delta(9)-tetrahydrocannabinol-induced impairment inhibition potentiated subcutaneous agonist (-)-quinpirole (25 500...
Abstract Background After primary maternal cytomegalovirus (CMV) infection during pregnancy, infants are at risk for disease. Methods Factors predictive of infant outcome were analyzed in a database 304 pregnant women with infection. These enrolled between 2010 and 2017 delivered 281 infants, whom 108 CMV infected. Long term follow-up occurred 173 uninfected 106 infected age 4 years (range, 1–8 years). One hundred fifty-seven treated an average 2 doses 1–6 doses) high-dose hyperimmune...
Collagen and matrix metalloproteinases (MMP) play a pivotal role in the pathophysiology of Pelvic Organ Prolapse (POP) as switch between type I III collagen together with simultaneous activation MMPs have been observed vaginal wall. The aim this study was to evaluate Advanced Glycation End (AGE) products, ERK1/2 transforming growth factor (TGF)-β/Smad pathway expression muscularis propria women POP compared control patients. We examined 20 patients 10 treated for uterine fibromatosis....
Induction of labor is a useful practice to solve many obstetric situations but has large impact on the health women and their babies therefore needs be clearly justified clinically.To determine sensitivity sonoelastography in evaluation cervix predict success induction.We enrolled 53 subjects preparing for induction labor. Transvaginal cervical length sonoelastogram were performed. We preliminarily classified sonoelastograms into five elastography index (EI) categories examined different...
The primary objective was to assess whether low-dose Interleukin-2 (IL-2) and 13-cis-retinoic acid (RA) could decrease serum vascular endothelial growth factor (VEGF) improve the immune function of patients with advanced ovarian cancer (AOC) responsive chemotherapy. secondary end-point compare response these that a group control patients, treated standard care. Forty-four AOC, responding chemotherapy elevated levels VEGF, were entered into study from 04/98 12/02. After chemotherapy, received...
Many evidence support the view that endometriotic cyst may exert detrimental effect on surrounding ovarian microenvironment so representing a risk to functionality of adjacent follicles. Patients with benign (endometriotic, follicular and dermoid cysts) subjected laparoscopic cystectomy were enrolled in present retrospective study order analyze whether tissue could negatively affect normal cortex more severely than other cysts. To this end we carried out immunohistochemistry analysis...
The study arises from the idea of analyzing reasons why many women in L'Aquila decided to conceive months following 2009 earthquake. In January June 2011, there was a +27.24% increase number newborns (+ 91) delivered Obstetrics and Gynecology Unit San Salvatore Hospital compared same six-month period 2010.Between 2010 December 2010, 874 gave birth L'Aquila. living outside were excluded study. remaining women, namely sample 451 individuals, administered questionnaire that focused on level...