A5089825984- Advanced Biosensing Techniques and Applications
- Virus-based gene therapy research
- CAR-T cell therapy research
- Nanoparticle-Based Drug Delivery
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- Nanopore and Nanochannel Transport Studies
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- Plasmonic and Surface Plasmon Research
- Receptor Mechanisms and Signaling
- Advanced Drug Delivery Systems
- Advanced biosensing and bioanalysis techniques
- 3D Printing in Biomedical Research
- Lipid Membrane Structure and Behavior
- Curcumin's Biomedical Applications
- Immunotherapy and Immune Responses
University of Helsinki
2015-2020
Vrije Universiteit Amsterdam
2018-2020
Helsinki Art Museum
2015
Data Harbor (United States)
2015
The stimulation of the immune system using oncolytic adenoviruses (OAds) has attracted significant interest and several studies suggested that OAds immunogenicity might be important for their efficacy. Therefore, we developed a versatile rapid to adsorb tumor-specific major histocompatibility complex class I (MHC-I) peptides onto viral surface drive response toward tumor epitopes. By studying model epitope SIINFEKL, demonstrated peptide-coated OAd (PeptiCRAd) retains its infectivity cross...
The surface plasmon resonance technique in combination with whole cell sensing is used for the first time real‐time label‐free monitoring of nanoparticle uptake. uptake kinetics several types nanoparticles relevant to drug delivery applications into HeLa cells determined. confirmed by confocal microscopy. silica and polyethylenimine–plasmid DNA polyplexes studied as a function temperature, energies are determined Arrhenius plots. phase transition temperature membrane detected when at...
The exploitation of curcumin for oral disease treatment is limited by its low solubility, poor bioavailability, and stability. Surface-functionalized poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) have shown promising results to ameliorate selective delivery drugs the gastro-intestinal tract. In this study, curcumin-loaded PLGA NPs (C-PLGA NPs) about 200 nm were surface-coated with chitosan (CS) mucosa adhesion, wheat germ agglutinin (WGA) colon targeting or GE11 peptide tumor...
Real-time label-free techniques are used to profile G protein-coupled receptor (GPCR) signaling pathways in living cells. However, interpreting the signal responses is challenging, and previously reported methods do not reliably separate from each other. In this study, a continuous angular-scanning surface plasmon resonance (SPR) technique utilized for measuring GPCR profiles. We show how ability, up nine real-time parameters simultaneously, results more information-rich profiles different...
Meeting abstracts Oncolytic adenoviruses (OAds) demonstrated great potential for the treatment of cancer in many pre-clinical studies. The pre-existing immunity and their immunodominance, however, still limit success oncolytic virotherapy patients. Thus, a transition from