The search for new antimicrobial compounds is ongoing. Its importance cannot be overemphasized in an era of emerging resistant pathogenic organisms. This study therefore investigated the phytochemical composition and antioxidant activities different citrus juice concentrates. Fruit juices Citrus tangerine (tangerine), paradisi (grape), limon (lemon), aurantifolia (lime) were evaluated. Antimicrobial against five bacterial three fungal strains results revealed presence alkaloids, flavonoids,...

Gallic acid (GA) is a known phenolic compound with anti-inflammatory, antioxidant, and anti-cancer activities. The objective of this research to evaluate the preventive role GA against carbon tetrachloride (CCl4) induced liver fibrosis. Thirty-five (35) male Wistar rats were used in study equally distributed into five groups (7 each). All acclimatized for week, Group I (control) administered distilled water only. II single dose CCl4 (1.25 mL/kg olive oil (1:1); IP) cause hepatic damage,...

Vernonia amygdalina and Ocimum gratissimum occupy prominent positions in the diets of several Nigerian ethnic groups. This study therefore compared phenolic content some antioxidative activities ethanolic leaf extracts these two plants. Ethanolic freshly plucked leaves were obtained using standard procedures. The antioxidant capacity vegetables quantified vitro. results show that O. contains higher amounts total phenolics (168.5 ± 5.50 97.0 0.01 mg gallic acid equivalents/g extract...

Pharmacognosy Research,2023,15,2,363-372.DOI:10.5530/pres.15.2.039Published:February 2023Type:Original Article Authors:Catherine Otitolaiye, Akhere Omonkhua, Kelly Oriakhi, Edward Okello, Iyere Onoagbe, and Friday Okonofua Author(s) affiliations:Catherine Otitolaiye1, 2, Omonkhua2,*, Oriakhi2, Okello3, Onoagbe4, Okonofua5 1Department of Biochemistry, Sokoto State University, Sokoto, NIGERIA. 2Department Medical School Basic Sciences, University Benin, Edo, 3Human Nutrition Research Centre,...

Tetracarpidium conophorum (TC) is a tropical plant used in ethno medicine for treating various diseases including hepatic ailments. The present study investigated the effect of methanol extract T. seeds rats intoxicated with CCl4 24 h and 48 after intoxication respectively. Thirty-five male Wistar were distributed equally into seven groups. Group IA (control) received distilled water olive oil (i.p), group IIA (600 mg/kg, i.p.) only on 8th day, while groups IIIA, IVA VA given 100 mg/kg...

The present study is to isolate and characterize betulinic acid ricinine from T. conophorum seeds. Phytochemical investigation on hexane fraction of seeds led the isolation two compounds, Betulinic (1), Ricinine (2). were screened against HepG2 cells tested in vivo CCl4-induced experimental rats model. Results this showed that compounds had hepatoprotective cytotoxic activities. It was observed inhibited cell with percentage inhibition 54% compared standard doxorubicin (64%), while inactive...

Purpose: To evaluate the effects of an okra-based diet on streptozotocin-induced diabetes mellitus in adult Wistar rats and its mechanism action.Methods: (6) were administered streptozotocin (50 mg/kg ip) after overnight fast. Upon confirmation mellitus, animals fed ad libitum for 21 days with formulated okrabased test place normal diet. The treated similarly served as diabetic control while not negative control. Thereafter, sacrificed, fasting bloodcollected analysed glucose concentration...

The present study investigated the combinatorial effect of gallic acid and catechin (GC) on some biochemical inflammatory parameters in CCl4-mediated hepatic damage to rats. Male Wistar rats were distributed equally into five groups. Group A (control) received distilled water orally olive oil intraperitoneally (ip), group B intoxicated with CCl4 {1.25 ml/kg oil, ip) only, while Groups C, D E induced CCl4, thereafter they administered 50 mg/kg body weight silymarin, combined dose (50 100 bw,...

Background:Aframomum danielli is used in ethno-medicine for the treatment of several ailments and as a traditional food spice. Methods: The hydro-distilled leaf, stem, seed, rhizome pod volatile oils A. were subjected to gas chromatography-mass spectrometry (GC-MS) analysis. Free radical scavenging capacity was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) ferric reducing antioxidant power (FRAP) assays. Results: Thirty-nine (39) compounds identified danielli, accounting 85.33 96.03%...

Abstract The present study was designed to evaluate the hypolipidemic activity of Tetracarpidium conophorum oil and its mechanism(s) action. extracted using Soxhlet method subjected column chromatography/spectroscopic techniques. GC-MS analysis performed on identify 15 constituents with 9,12,15-octadecatrienoic acid (ω-3 fatty or α-linolenic acid) (68%) showing highest proportion. Isolation purification gave three compounds, namely, β-sitosterol, stigmasterol, stearic (octadecanoic acid)....

Type 1 diabetes mellitus is an autoimmune disorder characterized by the destruction of pancreatic beta cells, leading to impaired insulin production and regulation. Recent research has shown that medicinal plants with antioxidant anti-inflammatory properties hold promise as potential therapeutic agents for managing complications disease. The aim this study investigate anti-diabetic, antioxidant, effect ethyl acetate extract Annona muricata leaves in streptozotocin (STZ)-induced Wistar rats....

Purpose: To investigate the potential anti-diabetic effect of supplementing a diet with Eucalyptus camaldulensis leaves in streptozotocin (STZ) induced Wistar rats. 
 Methods: Methanolic extract E. was screened using gas chromatography-mass spectrometric analysis. After that, eighteen animals were separated into three groups: Group A served as control group. B, diabetic group, STZ, and C STZ fed 10 % leaf-supplemented for 14 days. Thereafter, rats sacrificed, fasting blood collected...

Vitamins are a broad group of molecules with unique chemical, biological, and structural characteristics that necessary for normal metabolic process. This research evaluated the fat water-soluble vitamin composition mature (yellow) Carica papaya leaf using standard analytical techniques. The results obtained from analyses revealed contained following fat-soluble vitamins: vitamins A (5.08 mg/100g), Vitamin D (3.14 E (15.47 K (8.03 while include B1 (0.019 B2 (0.018 B3 (0.610 B6 (0.0231 12...

Diabetes is a metabolic disease, caused by significant abnormalities in insulin secretion or action on receptors. Many bioactive compounds from medical plants have demonstrated anti-diabetic efficacy with fewer side effects than synthetic medicines. This study was aimed at assessing the effect of hydroethanol extract mature (yellow) Carica papaya leaf streptozotocin-induced diabetes. Forty-eight Wistar male rats were placed into six groups eight animals per group: With exception Group A...

Background: Tetracarpidium conophorum (African walnut) is an African plant with ethnobotanical uses. Objectives: The purpose of this study was to evaluate the phytochemical screening and in vitro antioxidant activities methanol extract fractions (F) [n-hexane (HEX-F), dichloromethane (DCM-F) and, ethyl acetate (EA-F)] T. seeds. Methods: Phytochemical activity were carried out using DPPH, ABTs radical scavenging assays, nitric oxide inhibitory reducing potential assays. Results: Methanol its...

The phytochemical constituents, in vitro antioxidant activity and acute toxicity of the aqueous ethanol stem-bark extracts Alstonia boonei Anthocleista djalonensis were investigated. Phytochemical quantification test revealed that extract A. had a significantly higher (p<0.05) amount total phenol than other extracts. however levels flavonoid proanthocyanidin. DPPH’s radical scavenging (IC50 8.75±0.22) was better close to ascorbic acid standard 1.12±0.23). ability reduce ferric ions...

Squamous carcinoma of the head and neck is characterized by aberrant apoptosis that prolongs proliferative capacity cells uncontrolled cell growth. This study aimed to examine pro-apoptotic antiproliferative effects

Colorectal cancer is the third most prevalent malignant neoplasm in world and remains a leading cause of death, particularly western nations. This study aimed to evaluate apoptotic antioxidant activities Spondias mombin stem bark extracts dimethylhydrazine (DMH) induced colon Wistar rats as well investigate binding affinities epicatechin, kaempferol Lunamarin against p53 caspase 3 proteins. A total thirty-five (35) male were used for this experiment. They grouped into five groups: Group 1...

The Cheese wood (Alstonia boonei) tree, known as Egbu-ora in Igbo, Ahun Yoruba, Ukpukunu Urhobo and Ukhu Edo, is a widely distributed plant the lowlands rain-forest areas of Nigeria. It has been listed African Pharmacopoeia an antimalarial drug traditional medicine for treatment fever, painful micturition, insomnia, chronic diarrhoea, rheumatic pains antivenom snake bites arrow poisoning. This work aims to investigate phytochemical composition, vitro antioxidant, antimicrobial activities...

This study is aimed at evaluating the anticancer effect of aqueous extract

The continuous search for new compounds in natural-based plants is a promising strategy the prevention of diseases. This work examined antiglycation activity isolated from antidiabetic extract T. alnifolia stem bark via vitro and computational [molecular dynamics (MD)] approach. Phytochemical investigation ethyl acetate fraction application spectroscopic methods led to isolation elucidation 3 compounds: quercetin (1), kaempferol (2), gallic acid (3). Compounds 1, 2 were then screened...