A5041820445- Bioinformatics and Genomic Networks
- Erythrocyte Function and Pathophysiology
- Protein Degradation and Inhibitors
- Biomedical Research and Pathophysiology
- Trace Elements in Health
- Genetic Associations and Epidemiology
Beijing Anzhen Hospital
2024
Capital Medical University
2024
Institute of Hydrobiology
2023
Chinese Academy of Sciences
2023
Abstract Lysosome-related organelles (LROs) are a class of heterogeneous conserved in eukaryotes that primarily play role storage and secretion. An important function LROs is to mediate metal homeostasis. Chlamydomonas reinhardtii model organism for studying ion metabolism; however, structural functional analyses C. insufficient. Here, we optimized method purifying these from 2 populations cells: stationary phase or overloaded with iron. The morphology, elemental content, lysosomal...
Abstract Cardiovascular drug development has faced significant challenges in recent decades. The emergence of population-scale genome- and proteome-wide data, alongside sophisticated genetic analytical tools like Mendelian randomization pragmatic target trials, presents an unprecedented chance to identify validate drug-targeting proteins for cardiovascular disease. However, how translate these advances into clinical applications remains be discovered. This study proposes validates a...