Raphaël Ortiz

ORCID: 0000-0002-7437-3198
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About
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Research Areas
  • Microfluidic and Capillary Electrophoresis Applications
  • 3D Printing in Biomedical Research
  • Innovative Microfluidic and Catalytic Techniques Innovation
  • Computer Graphics and Visualization Techniques
  • Generative Adversarial Networks and Image Synthesis
  • Photoacoustic and Ultrasonic Imaging
  • 3D Shape Modeling and Analysis
  • Medical Imaging Techniques and Applications
  • Cellular Mechanics and Interactions
  • Legal Studies and Policies
  • Cancer Cells and Metastasis
  • Meningioma and schwannoma management
  • Advanced Vision and Imaging
  • Cell Image Analysis Techniques
  • Product Development and Customization
  • Manufacturing Process and Optimization
  • Electrowetting and Microfluidic Technologies
  • Advanced Image Processing Techniques
  • Business Process Modeling and Analysis
  • Image Enhancement Techniques
  • American Constitutional Law and Politics
  • RNA Research and Splicing
  • Legal and Social Justice Studies
  • Pharmaceutical and Antibiotic Environmental Impacts
  • Intracranial Aneurysms: Treatment and Complications

Walt Disney (Switzerland)
2022-2024

Friedrich Miescher Institute
2020-2023

University of Miami
2023

Walt Disney (United States)
2021

Nanyang Technological University
2014-2019

St. Luke's-Roosevelt Hospital Center
2012

Organoids provide an accessible in vitro system to mimic the dynamics of tissue regeneration and development. However, long-term live-imaging organoids remains challenging. Here we present experimental image-processing framework capable turning light-sheet imaging intestinal into digital organoids. The combines specific optimization combined with data processing via deep learning techniques segment single organoids, their lumen, cells nuclei 3D over long periods time. By linking lineage...

10.1038/s41467-022-32465-z article EN cc-by Nature Communications 2022-08-18

Gastruloids are 3D structures generated from pluripotent stem cells recapitulating fundamental principles of embryonic pattern formation. Using single-cell genomic analysis, we provide a resource mapping cell states and types during gastruloid development compare them with the in vivo embryo. We developed high-throughput handling imaging pipeline to spatially monitor symmetry breaking report an early spatial variability pluripotency determining binary response Wnt activation. Although...

10.1016/j.stem.2023.04.018 article EN cc-by-nc-nd Cell stem cell 2023-05-19

Microfluidic droplet reactors have many potential uses, from analytical to synthesis. Stable operation requires preferential wetting of the channel surface by continuous phase which is often not fulfilled materials commonly used for lab-on-chip devices. Here we show that a silica nanoparticle (SiNP) layer coated onto Poly(methyl methacrylate) (PMMA) and other thermoplastics enhances its properties creating nanoroughness, allows simple grafting hydrocarbon chains through silane chemistry....

10.1021/acsami.7b02682 article EN cc-by-nc-nd ACS Applied Materials & Interfaces 2017-04-05

Nucleoli are nuclear compartments regulating ribosome biogenesis and cell growth. In embryonic stem cells (ESCs), nucleoli containing transcriptionally active ribosomal genes spatially separated from pericentromeric satellite repeat sequences packaged in largely repressed constitutive heterochromatin (PCH). To date, mechanisms underlying such partitioning the physiological relevance thereof unknown. Here we show that repressive chromatin at PCH ensures structural integrity function of during...

10.1093/nar/gkac1159 article EN cc-by-nc Nucleic Acids Research 2022-12-13

Artistically controlling fluids has always been a challenging task. Recently, volumetric Neural Style Transfer (NST) techniques have used to artistically manipulate smoke simulation data with 2D images. In this work, we revisit previous NST for smoke, proposing suite of upgrades that enable stylizations are significantly faster, simpler, more controllable and less prone artifacts. Moreover, the energy minimization solved by methods is camera dependent. To avoid that, computationally...

10.1145/3550454.3555517 article EN ACM Transactions on Graphics 2022-11-30

This research is a response to the polemics and controversy over Constitutional Court's decision in Indonesia, which seen as failing maintain its independence deciding minimum age limit for presidential vice-presidential candidates. In this decision, Court having failed preserve dignity of judicial institution that should be free from conflicts interest influence any party determining decision. uses normative legal methods with conceptual, statutory, case approaches. The result study...

10.22373/petita.v9i2.299 article EN Petita Jurnal Kajian Ilmu Hukum dan Syariah 2024-09-02

The aim of the present work is to design and construct an ex vivo bioreactor system assess real time viability vascular tissue. Porcine carotid artery as a model tissue was used in setup monitor its under physiological conditions such oxygen, pressure, temperature, flow. evaluated by monitoring metabolism through fluorescent indicator “ resorufin. ” Our allows responses along with conditions. These parameters were vital determining sensor-enabled our initial investigations suggest that,...

10.1155/2015/958170 article EN cc-by BioMed Research International 2015-01-01

Complex water effluents pose a toxicity risk to biological wastewater treatments and environmental discharge. Dynamic sampling assessment of would mitigate downstream hazards, but few methods are available assess microorganism on the minute timescale. To rapidly evaluate unknown aqueous effluents, segmented-flow microfluidic device is refined for real-time gross detection quantification. A chip integrating magnetic stirrer serial dilution demonstrated determine EC50 values known toxicants,...

10.1016/j.mne.2019.02.002 article EN cc-by Micro and Nano Engineering 2019-02-14

Abstract Organoids provide an accessible in-vitro system to mimic the dynamics of tissue regeneration and development. However, long-term live-imaging organoids remains challenging. Here we present experimental image-processing framework capable turning light-sheet imaging intestinal into digital organoids. The combines specific optimization combined with data processing via deep learning techniques segment single organoids, their lumen, cells nuclei in 3D over long periods time. By linking...

10.1101/2021.05.12.443427 preprint EN cc-by bioRxiv (Cold Spring Harbor Laboratory) 2021-05-12

Recently, there has been exciting progress in frame interpolation for rendered content. In this offline rendering setting, additional inputs, such as albedo and depth, can be extracted from a scene at very low cost and, when integrated suitable fashion, significantly improve the quality of interpolated frames. Although existing approaches have able to show good results, most high-quality methods use synthesis network direct color prediction. complex scenarios, result unpredictable behavior...

10.1145/3588432.3591497 article EN 2023-07-19

While controlling simulated gaseous volumes remains an ongoing battle when seeking realism in computer graphics, creating appealing characters entirely out of these simulations brought this challenge to new level Pixar's film Elemental. For fire characters, like the protagonist "Ember", their faces and bodies needed look move real fire, but not be so frenetic as distract from acting emotion performances. Neural Style Transfer emerged a key technique achieving that met criteria. By using more...

10.1145/3587421.3595435 article EN 2023-08-06

Tajul Muluk and 274 former Shia have not been able to return their hometowns in Sampang District, even though they pledged repentance Sunni teachings on November 5, 2020. The formulated research problems consisted of: first, what was the position of adherents District based perspective rights freedom religion Indonesia? And second, form violation right case community rejection District? This utilizes empirical legal methods combined with sociological anthropological approaches. results...

10.15294/lesrev.v7i2.72156 article EN Lex Scientia Law Review 2023-11-30

Droplet-based bioassays are attractive for increasing throughput while minimizing reagent consumption. However, the choice of continuous oil phase within bioassay can substantially alter assay outcomes when hydrophobic reagents and analytes dynamically partition between aqueous phases. Fluorinated phases have been recognized as a better alternative to hydrocarbons prevent leakage from droplets but variations among them has not quantitatively addressed analysis is complicated by presence...

10.1016/j.mne.2019.05.001 article EN cc-by-nc-nd Micro and Nano Engineering 2019-05-01

This article examines the importance of state power in regulating religion a limited scope. is intended to solve classic problems, such as immediately fulfilling constitutional rights local religious adherents. Even though Constitutional Court partially recognizes existence religions through decision No.97/PUU-XIV/2016, this does not change legal status religions, which are considered official religions. research contributes efforts fulfill right freedom for followers Indigenous policy...

10.71239/jicl.v1i3.23 article EN 2024-12-16

Objectives: The HydroSoft and HydroFrame coils are a new generation of designed to further improve the safety durability aneurysm coiling using hydrogel technology. authors report their experience for treatment intracranial aneurysms.Methods: Immediate follow-up angiographic results, procedure-related complications, retreatments were retrospectively analyzed 106 saccular aneurysms in 103 patients treated with during 50-month period.Results: incidence thromboembolic complications was 5.7%....

10.5797/jnet.6.87 article EN cc-by-nc-nd Journal of Neuroendovascular Therapy 2012-01-01
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