A5011011674- Multiple Sclerosis Research Studies
- Genetic Associations and Epidemiology
- Systemic Lupus Erythematosus Research
- Epigenetics and DNA Methylation
- Retinoids in leukemia and cellular processes
- Celiac Disease Research and Management
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- RNA regulation and disease
- Neurotransmitter Receptor Influence on Behavior
- Systemic Sclerosis and Related Diseases
- Drug-Induced Hepatotoxicity and Protection
- Retinal Diseases and Treatments
- Poisoning and overdose treatments
- RNA Interference and Gene Delivery
- Animal testing and alternatives
- Bioinformatics and Genomic Networks
- Cannabis and Cannabinoid Research
- Pancreatic function and diabetes
- Carcinogens and Genotoxicity Assessment
- Pharmacogenetics and Drug Metabolism
- Environmental Toxicology and Ecotoxicology
- Antioxidant Activity and Oxidative Stress
- Neuroscience and Neuropharmacology Research
- Bipolar Disorder and Treatment
University of Newcastle Australia
2021-2024
Hunter Medical Research Institute
2021-2024
Azienda Ospedaliera Pugliese Ciaccio
2019
University of Perugia
2001-2007
Recent evidence suggests an altered glutamate homeostasis in the brain of patients with multiple sclerosis (MS), as seen experimental models MS.To test whether excitotoxic insult contributes to pathological process MS by measuring and aspartate levels cerebrospinal fluid control individuals.Twenty-five relapsing-remitting form during a stable clinical phase, 30 relapse, 25 secondary progressive were included study. Data compared those 20 age-matched subjects without diseases central...
Retinol is a fat-soluble vitamin that plays an essential role in many biological processes throughout the human lifespan. Here, we perform largest genome-wide association study (GWAS) of retinol to date up 22,274 participants. We identify eight common variant loci associated with retinol, as well rare-variant signal. An integrative gene prioritisation pipeline supports novel retinol-associated genes outside main transport complex (RBP4:TTR) related lipid biology, energy homoeostasis, and...
Sixty, relapsing remitting (RR) multiple sclerosis (MS) patients, who underwent treatment with glatiramer acetate (GA), interferon (IFN)-β 1a, and immunoglobulins (Igs) (20 per group), were assessed for levels of brain-derived neurotrophic factor (BDNF) in the supernatants unstimulated stimulated peripheral blood mononuclear cells (PBMCs) first year treatment. Phytohemagglutinin (PHA), anti-OKT3 antibody, myelin basic protein (MPB) GA used as stimuli. Cytokine responses by ELISPOT...
Abstract Cannabis use disorder (CUD) remains a significant public health issue globally, affecting up to one in five adults who cannabis. Despite extensive research into the molecular underpinnings of condition, there are no effective pharmacological treatment options available. Therefore, we sought further explore genetic analyses prioritise opportunities repurpose existing drugs for CUD. Specifically, aimed identify druggable genes associated with disorder, integrate...
Amiodarone is a class III antiarrhythmic drug widely used for treating number of cardiac arrhythmias such as atrial fibrillation, both in young and elderly people. Its hepatotoxicity usually mild occurs with delayed onset. Acute rare side effect; it sometimes related to intravenous administration. In that case, acute hepatocellular injury within 24 hours following amiodarone’s Liver enzymes significantly improve after stopping treatment. toxicity due administration believed depend on...
ABSTRACT Retinol is a fat-soluble vitamin that plays an essential role in many biological processes throughout the human lifespan. Previous work has characterised genetic influences on circulating retinol; however, small sample sizes have limited our ability to fully appreciate architecture of this trait. In study, we performed largest genome-wide association study (GWAS) retinol date up 22,274 participants. We identified eight common variant loci associated with retinol, as well...
Abstract Almost half of individuals diagnosed with schizophrenia also present a substance use disorder, however, little is known about potential molecular mechanisms underlying this comorbidity. We used genetic analyses to enhance our understanding the overlap between these conditions. Our revealed positive correlation and following dependence phenotypes: alcohol ( r g = 0.3685, SE 0.0768, P 1.61 × 10 −06 ), cannabis disorder 0.309, 0.0332, 1.19 −20 ) nicotine 0.1177, 0.0436, 7.0 10- 03 as...