A5038809003- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Optical Imaging and Spectroscopy Techniques
- Breast Cancer Treatment Studies
- Photoacoustic and Ultrasonic Imaging
- Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Nanoplatforms for cancer theranostics
- Pain Management and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Cancer Cells and Metastasis
- Optical Coherence Tomography Applications
- Myasthenia Gravis and Thymoma
- Photodynamic Therapy Research Studies
- Advanced Fluorescence Microscopy Techniques
- Diagnosis and Treatment of Venous Diseases
- Thyroid and Parathyroid Surgery
- Agricultural Productivity and Crop Improvement
- Peripheral Artery Disease Management
- Chemotherapy-related skin toxicity
- Multiple and Secondary Primary Cancers
- Horticultural and Viticultural Research
- Breast Lesions and Carcinomas
- Parkinson's Disease and Spinal Disorders
Saints Cyril and Methodius University of Skopje
2012-2024
PHI University Psychiatric Clinic - Skopje
2022
University Clinic of Traumatology
2011-2020
INTRODUCTION: The detection of estrogen, progesterone and HER-2 neu receptors on the surface tumour cell is a significant prognostic factor, alone or in combination. presence absence associated with conditional gene expression itself. Based these genetically determined expressions cell, five molecular subtypes breast cancer have been classified St. Gallen International Expert Consensus 2011 that can be immunohistochemically detected, each subtype manifesting certain prognosis aggression.AIM:...
Cancer affects one in three people worldwide. Surgery remains the primary curative option for localized cancers, but good prognoses require complete removal of tumors and timely recognition metastases. To expand surgical capabilities enhance patient outcomes, we developed a six-channel color/near-infrared image sensor inspired by mantis shrimp visual system that enabled near-infrared fluorescence guidance during surgery. The shrimp's unique eye, which maximizes number photons contributing to...
Abstract Introduction: Surgical stress response, results in elevated levels of anti-insulin hormones and reduced insulin secretion. This hormonal state may be detrimental for surgical patients due to the presence resistance hyperglycemia. Additionally, pre-operative fasting favors this conditions. The aim study is analyze impact caloric load, with 440kJ from amino acid infusions on glucose, cortisol patients. Material Methods: included 20 female scheduled mastectomy, aged 30-60 years without...
Pleural infection is a frequent clinical condition. Prompt treatment has been shown to reduce morbidity, mortality and duration of hospital stay. Unfortunately, advanced stages empyema need use extensive surgery - decortications or thoracoplasty. Early recognition the parapneumonic effusion adequate with thoracentesis pleural drainage, which minimally invasive, possible not prograde process become empyema.To analyze results surgical in patients treated at Clinic for thoracic surgery.In...
Near-infrared fluorescence image-guided surgery is often thought of as a spectral imaging problem where the channel count critical parameter, but it should also be multiscale field view and spatial resolution are similarly important.
Accurate assessment of HER-2 is imperative in selecting patients for targeted therapy. Most commonly used test methods are immunohistochemistry (IHC) and fluorescence situ hybridisation (FISH). We evaluated the concordance between FISH IHC breast cancer samples using Food Drug Administration approved tests.Archived paraffin tissue blocks from 73 were used. immunostaining was performed Ventana anti-HER-2 monoclonal antibody. The assay PathVysion™ DNA Probe Kit.Of cases 68.5% 0/1+, 15.07% 2+...
Abstract Aim: The aim of the study was to identify impact T stage, presence estrogen, progesterone, HER2neu receptors and values Ki67 on positivity for metastases axillary lymph nodes, from primary breast cancer. Material methods: 290 surgically treated patients cancer were included in study. All cases have been analyzed by standard histological analysis including microscopic H&E staining. For determining molecular - HER2neu, ER, PR, p53 Ki67, immunostaining PT LINK immunoperoxidase has...
The study aimed to identify factors that influence the positivity of axillary lymph nodes in patients with early breast cancer and clinically negative nodes, who were subjected for modified radical mastectomy lymphadenectomy.This included 81 surgically treated, during period from 08-2015 05-2017. All cases have been analysed by standard histological analysis including macroscopic microscopic examination routine H&E staining. For determination molecular receptors, immunostaining PT LINK...
Lymph node mapping is a routine procedure during numerous cancer surgeries, yet the intraoperative identification of affected lymph nodes remains clinical challenge. In response to this, we've introduced multispectral camera that covers UV, visible, and NIR spectrum. This innovative device facilitates imaging using both endogenious UV fluorescence exogenious fluorescence, aiding in pinpointing nodes. presentation will showcase relevant findings.
SignificanceSingle-chip imaging devices featuring vertically stacked photodiodes and pixelated spectral filters are advancing multi-dye methods for cancer surgeries, though this innovation comes with a compromise in spatial resolution. To mitigate drawback, we developed deep convolutional neural network (CNN) aimed at demosaicing the color near-infrared (NIR) channels, its performance validated on both pre-clinical clinical datasets.AimWe introduce an optimized CNN designed NIR images...
The authors present a rare case of giant mediastinal cyst which arises from the thymus gland, and goes down in both pleural spaces, especially right chest cavity where dominant part was present. full with 2.5 liters transparent fluid, compressed surrounding structures - heart lungs, one partially collapsed. patient 52 years old woman, without any clinical symptoms. Accidentally, on screened X-ray shading distal third detected. well documented CT chest, an indication for surgical treatment...
Abstract Posterior sternoclavicular joint dislocation is a rare condition. In this paper, we present 51-year-old male patient who was admitted to the emergency department in our hospital after he hit by mining railway wagon chest. A diagnosis of posterior confirmed performing CT scan. Following necessary preparations, stabilized with two wire cerclage techniques during open reduction. During control at postoperative 4th week, range motion shoulder satisfactory, but had mild pain level and...
Near-infrared fluorescence image-guided surgery relies on an interdisciplinary community to develop near-infrared fluorescent markers and sensitive cameras capable of mapping relevant structures during surgical procedures. As biochemists pursue a new generation fluorophores aimed at oncology other applications, optoelectronic engineers developing imagers have been slow adopt architectural improvements that will enhance outcomes in existing operations document characteristics are needed...
The staging of solid cancers is critical to the planning both primary treatment with surgery and adjuvant therapies like chemotherapy; however, not always possible preoperative information may require intraoperative evaluation sentinel lymph nodes confirm or disaffirm presence metastasis. Challenges are presented by standard-of-care node dissection which must be quick accurate enough guide surgical strategy despite a workflow that stretches from operating room pathology lab; solution posed...
Abstract Goodpasture syndrome is a rare autoimmune disease, with significant morbidity and mortality in young people otherwise healthy population. Complete disease remission possible prompt diagnosis treatment. We report 3 cases treated at the Department of Nephrology, University Clinic different outcome. All patients were similar clinical feature, renal failure that needed treatment hemodialysis. But results plasmapheresis indicate this procedure reduces syndrome. The course outcome...