A5046385250- Pleural and Pulmonary Diseases
- Hemoglobin structure and function
- Ultrasound in Clinical Applications
- Pneumonia and Respiratory Infections
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Congenital Diaphragmatic Hernia Studies
- Lung Cancer Diagnosis and Treatment
- Pesticide Exposure and Toxicity
- Pancreatic function and diabetes
- Respiratory Support and Mechanisms
- Advanced Proteomics Techniques and Applications
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Sepsis Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Dermatological and COVID-19 studies
- Blood properties and coagulation
- Hepatitis B Virus Studies
- Bone and Joint Diseases
- Neuroendocrine Tumor Research Advances
- Fibroblast Growth Factor Research
- Carcinogens and Genotoxicity Assessment
- Human Health and Disease
- Vaccine Coverage and Hesitancy
- Vector-borne infectious diseases
- Zoonotic diseases and public health
Saints Cyril and Methodius University of Skopje
2016-2024
PHI University Psychiatric Clinic - Skopje
2020-2024
University Clinic of Traumatology
2012
Roswell Park Comprehensive Cancer Center
1989-1990
Institute for Biological Sciences
1987-1989
Human rIL-6, produced either in COS cells or Escherichia coli, similarly stimulates the production of acute phase plasma proteins cultured human and rat hepatoma cells. This anabolic effect suggested a potential vivo role cytokine mediating hepatic response to inflammation. Injection IL-6 into adult male rats elicited cytokine-specific change liver expression proteins. As predicted from vitro studies, glucocorticoids were needed achieve maximal vivo. Optimal conditions found be two i.p....
Hepatic expression of the haptoglobin (Hp) gene in mammalian species is stimulated severalfold during an acute-phase reaction. To identify molecular mechanism responsible for this regulation, single-copy rat Hp has been isolated. The genomic sequences showed a high degree homology with primate gene. Activity was increased cultured liver cells by interleukin-1 (IL-1), IL-6, and glucocorticoids. sequence spanning from -6500 to +6500, when transiently introduced into human hepatoma (HepG2)...
The transcription rate of the haptoglobin (Hp) gene is stimulated by interleukin-1 (IL-1), IL-6, and dexamethasone in rat hepatoma (H-35) cells. To identify cis-acting regulatory elements responsive to these hormones, various lengths 5' Hp gene-flanking regions, including promoter, were inserted into chloramphenicol acetyltransferase expression vectors transiently introduced H-35 first 4 kb region mediated a severalfold increase after treatment with IL-6 dexamethasone. No response IL-1 was...
BACKGROUND: Post-COVID conditions can include a wide range of ongoing health problems. As consequence long COVID-19 or post-COVID-19 an increase in osteonecrosis has been detected different series patients. CASE PRESENTATION: We present two patients diagnosed with and pneumonia, one moderate the other severe clinical picture. They were treated corticosteroid equivalent to prednisolone 993.5 mg (400–1587 mg) which correlates steroid dose documented literature as causative for avascular...
ObjectivesDespite a 92-99% national vaccination coverage since 2000, the former Yugoslav Republic of Macedonia experienced large measles outbreak between 2010 and 2011. Here we investigate characteristics patients hospitalized during this at Clinic Infectious Diseases in Skopje. MethodsEpidemiological, clinical laboratory data 284 patients, including 251 from Skopje (43.80% 573 reported cases) 33 elsewhere were collected. ResultsThe most affected age groups children up to 4 years...
Parapneumonic effusions complicating pneumonia are associated with increased morbidity and mortality.To determine the role of clinical, laboratory radiographic features to differential diagnosis patients community- acquired (CAP) without effusion, uncomplicated parapneumonic effusion (UCPPE) complicated (CPPE).We analysed 148 CAP 50 UCPPE 44 CPPE. In three groups patients, majority was male (58.11%, 58%, 61.36%) consequently.The chronic heart failure most common comorbidity in a group (28;...
Hepatic expression of the haptoglobin (Hp) gene in mammalian species is stimulated severalfold during an acute-phase reaction. To identify molecular mechanism responsible for this regulation, single-copy rat Hp has been isolated. The genomic sequences showed a high degree homology with primate gene. Activity was increased cultured liver cells by interleukin-1 (IL-1), IL-6, and glucocorticoids. sequence spanning from -6500 to +6500, when transiently introduced into human hepatoma (HepG2)...
Pleural infection is a frequent clinical condition. Prompt treatment has been shown to reduce morbidity, mortality and duration of hospital stay. Unfortunately, advanced stages empyema need use extensive surgery - decortications or thoracoplasty. Early recognition the parapneumonic effusion adequate with thoracentesis pleural drainage, which minimally invasive, possible not prograde process become empyema.To analyze results surgical in patients treated at Clinic for thoracic surgery.In...
ABSTRACT Objective: COPD is one of the major causes morbidity and mortality worldwide. Health care providers should counsel their smoking patients with to quit as first treatment step. However, in countries high prevalences smoking, health workers may also be smokers. The aim this study was determine frequency severity who smoke. Methods: This a cross-sectional study. All smoke, from nine centers Serbia, were invited participate perform spirometry. diagnosis based on post-bronchodilator...
BACKGROUND: Parapneumonic effusion (PPE), as a complication of community-acquired pneumonia, sometimes progresses into complicated PPE (CPPE) and empyema, thus becoming significant clinical problem. There is lack guidelines for antibiotic therapy reports on local microbiological status resistance microorganisms. AIM: Тhe paper focused the analysis findings that are affecting patient outcomes length treatment. METHODS: We analyzed 94 patients, 50 with uncomplicated (UCPPE) 44 CPPEs. RESULTS:...
Abstract Introduction: Parapneumonic effusions, as a complication of community-acquired pneumonia (CAP), usually have good course, but they sometimes progress into complicated parapneumonic effusion (CPPE) and empyema, thus becoming significant clinical problem. Aim: To review radiological features, well diagnostic therapeutic options in effusions. Material methods: The analysis included 94 patients with hospitalized at the University Infectious Diseases Clinic Skopje during 4 year period....
Abstract The aim of this study was to identify the participations serum coagulations and fibrinolysis factors that contribute differential diagnosis patients with community-acquired pneumonia (CAP) without effusion, uncomplicated parapneumonic effusion (UCPPE) complicated (CPPE). system is fundamental for maintenance homeostasis, contributes inflammatory process responsible CAP effusion. participate in cellular proliferation migration as synthesis mediators. We evaluated laboratory profile...
Abstract Rotavirus is highly contagious factor with dominant feces-oral transmission. Because it stable in external environment, transmission clusters are possible by close contact, ingestion of contaminated water or food contact surfaces. It survives within hours and days on hands This makes the most common enteric nosocomial pathogen world, especially early childhood. In addition to rapid dehydration pronounced electrolyte disturbances, numerous extraintestinal possibilities have been...
Objective: The aim of the study was to determinate incidence and describe clinical manifestations acute Coxiella burnetii infection in adult hospitalized patients with community acquired pneumonia (CAP). Materials methods: A total 403 adults CAP within five year period (2002–2007) were included our study. mean age 49,86 years, 211 (52,36%) male 192 (47,64%) female. Diagnosis established by serological confirmation detection IgM IgG anttibody against burneti Ag Pneumoslide M G (vircell) IF...
<b>Introduction:</b> Chronic obstructive pulmonary disease (COPD) is one of the major causes morbidity and mortality worldwide. Smoking cessation counseling by their healthcare providers first treatment step in COPD patients, however countries with high prevalence smoking health-care workers may also be smokers. <b>Aim:</b> The aim study was to determine frequency severity who smoke. <b>Methods:</b> designed as a cross-sectional study. All smokers from nine health centers Serbia were invited...