A5017054842- Nosocomial Infections in ICU
- Sepsis Diagnosis and Treatment
- Influenza Virus Research Studies
- COVID-19 Clinical Research Studies
- Antibiotic Use and Resistance
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Climate Change and Health Impacts
- Long-Term Effects of COVID-19
- Emergency and Acute Care Studies
- Clinical Reasoning and Diagnostic Skills
- Bacterial Infections and Vaccines
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Resistance in Bacteria
- Brucella: diagnosis, epidemiology, treatment
- COVID-19 epidemiological studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Neuroscience of respiration and sleep
- Hepatitis Viruses Studies and Epidemiology
- Intensive Care Unit Cognitive Disorders
- COVID-19 Impact on Reproduction
- Patient Satisfaction in Healthcare
- Burkholderia infections and melioidosis
- Systemic Lupus Erythematosus Research
- Antimicrobial Resistance in Staphylococcus
PHI University Psychiatric Clinic - Skopje
2019-2023
Saints Cyril and Methodius University of Skopje
2016-2023
Victor Babeș University of Medicine and Pharmacy Timișoara
2022
Ospedale Garibaldi
2022
University Clinic of Traumatology
2012-2022
University Clinical Centre
2020
The last report of Crimean-Congo haemorrhagic fever (CCHF) in North Macedonia was more than 50 years ago the northwest. We on a fatal CCHF case following Hyalomma tick bite east country July 2023. Tracing 67 contacts identified one healthcare worker (HCW) providing care for patient. Monitoring is concluded (including further 11 HCW contacts), thus far 28 days after death no additional cases were identified.
We explored the self-reported antibiotic stewardship (AS), and infection prevention control (IPC) activities in intensive care units (ICUs) of different income settings. A cross-sectional study was conducted using an online questionnaire to collect data about IPC AS measures participating ICUs. The participants were Infectious Diseases-International Research Initiative (IDI-IR) members, committed as per their institutional agreement form. analyzed responses from 57 ICUs 24 countries...
Our aim was to determine the risk factors on mortality in adult patients with community-acquired severe sepsis and septic shock. The main outcome measure hospital mortality. This prospective single centre study conducted from January 1, 2008 December 31, 2010, included 184 patients, of whom 135 (73.4%) were 49 (26.6%) had Overall, ninety-five (51.6%) have died, 60 (44.4%) 35 (71.4%) lung most common site infection 121 (65.8%), chronic heart failure frequent comorbidity 65 (35.3%). Logistic...
This prospective, non-randomized trial, compared the efficacy and tolerance of a doxycycline-rifampin regimen, administered for 45 days, versus given days plus gentamicin first 7–10 in treatment human brucellosis. Of 238 patients that were initially included study, 181 finally evaluated. Ninety-four treated with 87 doxycycline-rifampin-gentamicin regimens. In group: relapses noted 13 (13.8%) patients; therapeutic failures five (5.3%); mild adverse effects 28 (29.8%). four (4.6%) relapsed;...
Abstract Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to an infection and it major cause of morbidity mortality worldwide. The aim this study describe epidemiology community-acquired sepsis in the Intensive care unit (ICU) Macedonian tertiary University Clinic for Infectious Diseases. A prospective observational was conducted over 6-year period from January, 2011 December, 2016. All consecutive adults with or septic shock were included study....
Background. The aim of this study was to evaluate the ability severity scoring systems predict 30-day mortality in patients with severe community-acquired pneumonia. Methods. included 98 aged ≥18 years community acquired pneumonia hospitalized at Intensive Care Unit University Clinic for Infectious Diseases Skopje, Republic North Macedonia, during a 3-year period. We recorded demographic, clinical and common biochemical parameters. Five scores were calculated admission: CURB 65 (Confusion,...
Background/aim: Hematological parameters are the starting point in COVID-19 severity classification. The aim of this study was to analyze oxidative stress hospitalized patients and determine its association with D-dimer, neutrophil lymphocyte ratio (NLR), platelets (PLR) as markers for disease progression. Materials methods: 52 moderate severe forms were enrolled. A hematological coagulation profile performed each patient. PAT (total antioxidant power, iron-reducing) d-ROMs (plasma...
Abstract Introduction: Seasonal influenza, although often presented as a mild, self-limiting disease, is frequently accompanied by complications that lead to the development of severe clinical presentation and fatal outcome. The most common are respiratory complications, with secondary bacterial pneumonia being leading cause. Aim: aim this study determine impact on severity outcome in patients seasonal influenza. Materials Methods: This research comparatively group-based has been conducted...
Abstract Introduction. The risk factors associated with the progression of a severe clinical form seasonal influenza are particular importance in developing current and accurate decision terms treatment options. Aim. aim study was to identify specific influenza. Method. conducted as prospective, group comparison at University Clinic for Infectious Diseases Skopje, Macedonia, during period January 01, 2012, until 2015. This analyzed 122 adult patients, who were clinically-confirmed be...
The aim of this study was to evaluate the usability systemic inflammatory response syndrome (SIRS) and commonly used biochemical parameters as predictors for positive blood culture in patients with sepsis. included 313 aged ≥18 years severe sepsis septic shock consecutively admitted Intensive Care Unit (ICU) University Clinic Infectious Diseases Skopje, Republic North Macedonia. took place from January 1, 2011 December 31, 2017. We recorded demographic variables, common laboratory tests,...
Abstract Rotavirus is highly contagious factor with dominant feces-oral transmission. Because it stable in external environment, transmission clusters are possible by close contact, ingestion of contaminated water or food contact surfaces. It survives within hours and days on hands This makes the most common enteric nosocomial pathogen world, especially early childhood. In addition to rapid dehydration pronounced electrolyte disturbances, numerous extraintestinal possibilities have been...
Elderly patients and with different comorbid conditions are at a higher risk of developing severe clinical course lethal influenza outcome. The aim this study was to define in form seasonal influenza, their influence on prospective, group comparison conducted the University Clinic for Infectious Diseases Skopje, Macedonia, during period January 01, 2012 2015. included 87 adult who were further categorized either survived (n=75) deceased (n=12). Demographic parameters patients, as well any...
Our objective was to investigate the inflammatory and oxidative stress markers in patients with moderate severe form of COVID-19. In addition, we show correlation between changes lymphocyte subsets as a tool for patient classification. IL-6 VEGF were analysed by utilizing High Sensitivity Evidence Investigator™ Biochip Array technology. The total antioxidant capacity (PAT) free radical concentrations (d-ROM) measured serum analytical photometric system FRAS5. Peripheral blood used determine...
At the Clinic of Infectious Diseases from April till October 2005, 93 patients were admitted with clinical signs aseptic meningitis. The CSF samples obtained by lumbal puncture cytological, biochemical, bacteriological and serological examined (analyzed). Enteroviral group antigen was detected (confirmed) i 8 samples. slidex meningite kite test negative. All at age 1–25 years, predominations male (62), females presented 31. WBC count in ranged 37 658, average 201/mm3. lymphocyte...
Seasonal influenza complications are the cause of development severe clinical picture as well death. The most common respiratory ones, and leading one that stands out is secondary bacterial pneumonia. aim this study determining pneumonia impact on severity outcome for patients with influenza. research prospectively compared in groups, carried at University Clinic Infectious Diseases during a 3-year period. 122 adult laboratory confirmed have been analyzed. Based picture, were divided into...