A5033455605- Brucella: diagnosis, epidemiology, treatment
- Burkholderia infections and melioidosis
- Animal Diversity and Health Studies
- Viral Infections and Vectors
- Leptospirosis research and findings
- Galectins and Cancer Biology
- Hematological disorders and diagnostics
- Immunotherapy and Immune Responses
- Vector-borne infectious diseases
- Hepatitis B Virus Studies
- Atherosclerosis and Cardiovascular Diseases
- Mosquito-borne diseases and control
- Salmonella and Campylobacter epidemiology
- Liver Disease Diagnosis and Treatment
- Streptococcal Infections and Treatments
- Hepatitis C virus research
- Thermal Regulation in Medicine
- Zoonotic diseases and public health
- T-cell and B-cell Immunology
- Celiac Disease Research and Management
- Immune responses and vaccinations
- Escherichia coli research studies
- Insect and Pesticide Research
- Sepsis Diagnosis and Treatment
- Infections and bacterial resistance
PHI University Psychiatric Clinic - Skopje
2019-2025
Saints Cyril and Methodius University of Skopje
2016-2025
British Society for Antimicrobial Chemotherapy
2019-2021
Hamedan University of Medical Sciences
2019-2020
University of Makeni
2016
University Clinic of Traumatology
2010-2015
Japan Society of Chemotherapy
2010
University Hospital of Ioannina
2005
Brucellosis is probably the commonest anthropozoonotic infection worldwide [1–3], but remains in various aspects an enigma 21st century [4]. Brucella melitensis major cause of human disease worldwide, followed by B. abortus and suis, while rare persisting cases canis novel pathogens marine mammals have also emerged. The re-emerging as a significant travel-related [5] represents index poor socioeconomic status (Figure 1). Its treatment largely based even today on principles applied half ago...
Bacteria of the genus Brucella are facultative intracellular parasites that cause brucellosis, a severe animal and human disease. Recently, group taxonomists merged brucellae with primarily free-living, phylogenetically related
Brucellosis is a zoonotic disease that remains endemic worldwide. Its clinical manifestations and focal complications are often troublesome in making diagnosis. Involvement of the respiratory system brucellosis an acknowledged but rare event only occasionally described literature. We describe 37 cases involvement during course presented as pneumonia, bronchopneumonia, pleural effusion with predominance monocytic or lymphocytic infiltrates, paroxysmal dry cough. also discuss aspects...
To present our 10-year clinical experience with brucellosis patients at the University Clinic for Infectious Diseases and Febrile Conditions in Skopje, Republic of Macedonia.A total 550 treated between 1998 2007 were retrospectively assessed their demographic, epidemiological, characteristics outcomes.Of patients, 395 (72%) male. The median age was 34.5 years (range, 1-82). Direct contact infected animals recorded 333 (61%) positive family history 310 (56%). most frequently seen symptoms...
ABSTRACT No data on whether brucellar meningitis or meningoencephalitis can be treated with oral antibiotics an intravenous extended-spectrum cephalosporin, namely, ceftriaxone, which does not accumulate in phagocytes, should added to the regimen exist literature. The aim of a study conducted Istanbul, Turkey, was compare efficacy and tolerability ceftriaxone-based antibiotic treatment regimens those protocol patients these conditions. This retrospective enrolled 215 adult 28 health care...
ObjectiveThe aim of this study was to describe some demographic, clinical and laboratory characteristics, evaluate the outcome, in patients with brucellosis an endemic area Balkan Peninsula, reveal differences between without occupational exposure.MethodsThe carried out at Clinic for Infectious Diseases Skopje over a period seven years. Four hundred eighteen were enrolled classified into two groups: (251) (167) exposure.ResultsTwo twenty-eight (54.5%) had positive family history. The most...
A 26-year-old man from North Macedonia developed tick-borne encephalitis (TBE) after a tick bite in Switzerland, experiencing severe neurological symptoms before full recovery. This case highlights the importance of vaccination and awareness for travellers non-endemic regions visiting TBE-endemic areas.
Immune evasion strategies of Brucella, the etiologic agent brucellosis, a global zoonosis, remain partially understood. The omentum, tertiary lymphoid organ part visceral adipose tissue, has never been explored as Brucella reservoir. We report that B. abortus infects and replicates within murine omental macrophages. Throughout chronic phase infection, omentum accumulates macrophages, monocytes neutrophils. maintenance PD-L1+Sca-1+ neutrophils in depends on wadC-encoded determinant LPS....
In recent years, there has been a significant increase in scientific productivity—an increased number of published original articles, reviews, short communications, case reports, and letters to the editor. this regard, is large peer-reviewed journals all fields knowledge, including field biomedical sciences. Many studies indicate existence so-called journal editorial board bias acknowledge difficulty eliminating it. We present our brief opinion on an important topic such as how publishing...
Cervical lymph nodes (CLN) are the first encountered by material taking oral route. To study their role in orally acquired infections, we analyzed 307 patients of up to 14 years treated university clinic Skopje, Macedonia, for brucellosis, a zoonotic bacterial disease frequently ingestion contaminated dairy products. From these children, 36% had lymphadenopathy. Among infected lymphadenopathy with CLN being only affected was significantly more frequent as compared those contact animals (83%...
Abstract Background Fever of unknown origin (FUO) and inflammation (IUO) are syndromes commonly used as medical diagnoses. Since the existing literature has a mixture diagnostic approaches, developing consensus-based recommendations would be helpful for clinicians, researchers, patients. Methods A modified Delphi process was performed from October 2022 to July 2023, involving 4 rounds online surveys 2 live video conferences. The panel comprised international experts recruited based on...
To describe the main epidemiological, clinical, and laboratory features, treatment options outcome in children with brucellosis.Retrospectively evaluated data were obtained from 317 pediatric patients brucellosis that treated at University Clinic for Infectious Diseases Febrile Conditions Skopje, during period 1989 to 2011. The medical records follow-up protocols used evaluation.Childhood composed (18.7%) of 1691 brucellosis. median 9 years old, ranging 7 months 14 years, 201 (63.4%) males....
To describe the main clinical and laboratory characteristics, frequency distribution of osteoarticular involvement, therapeutic options outcome in children with brucellosis.This descriptive study includes 133 pediatric patients brucellosis who were treated at University Clinic for Infectious Diseases Febrile Conditions Skopje, Republic Macedonia, during period between 1989 2011. Brucellosis was presumptively diagnosed on basis signs confirmed by detection specific antibodies significant...
To present clinical and laboratory features, treatment options, outcome in patients with brucellar testicular infection to compare them analogous without involvement.Thirty four treated two general hospitals the Republic of Macedonia, during period 1998-2009, were retrospectively analyzed. Their characteristics compared 364 male infection, who at same time period.Brucellar was evident 34 (8.5%) out 398 brucellosis. The median age 46.5 years. In all involvement presented as an acute form a...
So far, hematopoietic stem cells (HSC) are considered the source of mature immune cells, latter being only ones capable mounting an response. Recent evidence shows HSC can also directly sense cytokines released upon infection/inflammation and pathogen-associated molecular pattern interaction while keeping a long-term memory previously encountered signals. Direct sensing danger signals by induces early myeloid commitment, increases effector cell numbers, contributes to efficient Here, using...
Lyme borreliosis (LB) and tick-borne encephalitis (TBE) are important diseases in Europe. This study aimed to investigate the seroreactivity against Borrelia burgdorferi TBE virus (TBEV) tick-infested individuals North Macedonia Serbia. Serum samples were collected from healthy same regions. Samples tested for anti-Borrelia IgG reactivity TBEV-neutralizing antibodies. Results showed higher antigens patients donors Novi Sad compared those Skopje region. However, there was no statistically...
The Balkan Peninsula, acting as a crossroad between central Europe and the Middle East, presents diverse ecosystems supporting various tick species capable of transmitting TBDs. This study focuses on Serbia North Macedonia, both endemic for TBDs, aiming to investigate human-biting ticks' prevalence, TBD major TBPs in blood samples.