A5012068347- Dermatology and Skin Diseases
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Pain Mechanisms and Treatments
- CAR-T cell therapy research
- Ion Channels and Receptors
- Head and Neck Surgical Oncology
- Immunotherapy and Immune Responses
- Immune responses and vaccinations
- Stress Responses and Cortisol
- Circadian rhythm and melatonin
- Herpesvirus Infections and Treatments
- Wound Healing and Treatments
Centre d’Immunologie de Marseille-Luminy
2013-2023
Aix-Marseille Université
2014-2023
Inserm
2013-2023
Innate Pharma (France)
2021
Centre National de la Recherche Scientifique
2014
National Heart Lung and Blood Institute
2013
National Institutes of Health
2013
It has recently been demonstrated that memory B cells can reenter and reengage germinal center (GC) reactions, opening the possibility multi-hit lymphomagenesis gradually occurs throughout life during successive immunological challenges. Here, we investigated this scenario in follicular lymphoma (FL), an indolent GC-derived malignancy. We developed a mouse model recapitulates FL hallmark t(14;18) translocation, which results constitutive activation of antiapoptotic protein cell 2 (BCL2)...
Abstract Host protection against cutaneous herpes simplex virus 1 (HSV-1) infection relies on the induction of a robust adaptive immune response. Here, we show that Nav 1.8 + sensory neurons, which are involved in pain perception, control magnitude CD8 T cell priming and expansion HSV-1-infected mice. The ablation -expressing neurons is associated with extensive skin lesions characterized by enhanced inflammatory cytokine chemokine production. Mechanistically, required for downregulation...
So far, hematopoietic stem cells (HSC) are considered the source of mature immune cells, latter being only ones capable mounting an response. Recent evidence shows HSC can also directly sense cytokines released upon infection/inflammation and pathogen-associated molecular pattern interaction while keeping a long-term memory previously encountered signals. Direct sensing danger signals by induces early myeloid commitment, increases effector cell numbers, contributes to efficient Here, using...
The presentation of the Working Formulation for non-Hodgkin lymphomas by C. Berard was highlight 1-ICML, although at that time Hodgkin lymphomas, cell origin still unknown and even it could not yet be completely excluded, a neoplastic disease.Remembering one realizes huge evolution our lymphoma understanding has meanwhile taken place.ICML hereby played pivotal role only as platform exchanging knowledge but also an event catalyzing initiation collective efforts, which have led to some most...