A5067446279- Protease and Inhibitor Mechanisms
- Hormonal Regulation and Hypertension
- Heart Failure Treatment and Management
- Receptor Mechanisms and Signaling
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Fibrosis and Remodeling
- Respiratory Support and Mechanisms
- Biomarkers in Disease Mechanisms
- Nitric Oxide and Endothelin Effects
- Peptidase Inhibition and Analysis
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Cancer-related molecular mechanisms research
- Cardiac electrophysiology and arrhythmias
- Mesenchymal stem cell research
- Adipose Tissue and Metabolism
- Renin-Angiotensin System Studies
- Homelessness and Social Issues
- Cardiac, Anesthesia and Surgical Outcomes
- Substance Abuse Treatment and Outcomes
- Peroxisome Proliferator-Activated Receptors
- Cannabis and Cannabinoid Research
Hospital de Clínicas de Porto Alegre
2007-2024
Universidade Federal do Rio Grande do Sul
2010-2024
Universidade Luterana do Brasil
2007
Background MicroRNAs (miRs) are a class of small non-coding RNAs that regulate gene expression. Studies transgenic mouse models have indicated deregulation single miR can induce pathological cardiac hypertrophy and failure. The roles miRs in the genesis physiological left ventricular (LVH), however, not well understood. Objective To evaluate global expression an experimental model exercise-induced LVH. Methods Male Balb/c mice were divided into sedentary (SED) exercise (EXE) groups....
Objective: To investigate serum levels and genetic polymorphisms of matrix metalloproteinases (MMPs) -1, -3 -9 in patients submitted to carotid endarterectomy.
MicroRNAs are associated with myocardial damage and heart failure (HF). The present study investigated whether the plasma levels of microRNA (miR)‑21, ‑126 ‑423‑5p alter according to (de)compensated state patients HF all‑cause mortality. In 48 admitted emergency room for an episode acute decompensation, blood samples were collected measure miR B‑type natriuretic peptide within 24 h hospital admission, at time discharge, a number weeks post‑discharge (chronic stable compensated state). Levels...
MicroRNAs (miRs) regulate processes involved in both cardiac remodeling and obesity. We investigated if the expression of selected miRs patients with heart failure (HF) is influenced by presence obesity.In this case-control study, we compared plasma levels miR-21, -130b, -221, -423-5p, -221/-130b ratio 57 age- gender-matched subjects: 40 HF (20 obese 20 lean HF) 17 healthy controls. Body composition was estimated bioelectrical impedance analysis. MiRs were measured quantitative reverse...
Background Neutrophil-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR), and platelets-lymphocyte (PLR) are biomarkers easy-to-obtain could be used in clinical practice to verify an inflammatory status associated with alcohol use disorder (AUD) cocaine (CUD). Our aim was compare NLR, MLR PLR among men AUD CUD assess the relationship between these addiction-related outcomes.
We investigated whether the combination of β 1 -Gly389Arg and GNB3 C825T, two genetic polymorphisms strictly related to adrenergic system modulation, could act as predictors appropriate therapies in patients with heart failure (HF) using implantable cardioverter-defibrillators (ICDs). Patients HF ICD implantation for primary secondary prevention were studied. All registered classified (secondary ventricular tachycardia) or inappropriate (others). Genetic analysis was performed by polymerase...
Endothelial nitric oxide synthase (eNOS) gene polymorphisms have been associated with the pathogenesis of cardiovascular diseases, but few studies evaluated role eNOS haplotypes on risk and prognosis heart failure (HF). This prospective study was designed to analyze impact three (T-786C, VNTR4a/b Glu298Asp) their susceptibility clinical outcomes in HF outpatients systolic dysfunction.We conducted a case-control cohort which 316 patients 360 healthy controls were recruited from tertiary care...
Matrix metalloproteinases (MMPs) play an important role in the pathogenesis of atherosclerosis, pathology underlying majority coronary artery disease (CAD). In this study we tested hypothesis that polymorphic variation MMP genes influences risk developing atherosclerosis. We analyzed functional polymorphisms promoter MMP-1, MMP-3, MMP-9 and MMP-12 183 Brazilian Caucasian individuals submitted to angiography, which 67 (37%) had normal arteries (control group) 116 (63%) CAD (CAD patient...
Genetic polymorphisms of adrenergic receptors (ARs) have been associated with the development, progression, and prognosis patients heart failure (HF), few data for Brazilian population. We evaluated role β2-AR Thr164Ile polymorphism at codon 164 on in a prospective study 315 adult HF patients, predominantly middle-aged Caucasian men functional class I-II, severe left ventricular systolic dysfunction. Genomic DNA was extracted from peripheral blood β2-AR164 genotypes were detected by PCR...
Metabolic syndrome (MS) is associated with increased cardiovascular risk. It not clear whether myocardial changes showed in this syndrome, such as diastolic dysfunction, are due to the systemic effects of or specific effects.Compare function, biomarkers representing extracellular matrix activity (ECM), inflammation and cardiac hemodynamic stress patients MS healthy controls.MS (n = 76) controls (n=30) were submitted a clinical assessment, echocardiographic study, measurement plasma levels...
Aims: Vitamin E is a usual antioxidant, but little known about its effects on cardiac hypertrophy and microRNAs (miRs) expression induced by transverse aortic constriction (TAC) in mice. Methods Results: Male Balb/c mice were randomly divided into four cohorts: SHAM ( n= 22), TAC n =34), supplemented with vitamin (SHAM+VIT, =22), (TAC+VIT, =34). VIT groups received 200 mg/kg of α-tocopherol once day, the other placebo, both gavage. After 7 35 days surgery analysis hypertrophy, fibrosis, miRs...
Sepsis and septic shock are complex inflammatory syndromes. Multiple cellular activation processes involved, many humoral cascades triggered. Presumably, endothelial cells play a pivotal rule in the pathogenesis of sepsis, not only because they may influence cascade but also because, upon interaction with excessive amounts mediators, function these become impaired. It is likely that general dysfunction endothelium key event sepsis [1]. HMG-CoA-reductase inhibitors have been shown to exhibit...
We aimed to assess the effect of N-acetylcysteine (NAC), as an adjuvant treatment, on treatment adherence (primary outcome), in peripheral biomarkers and clinical improvement (secondary outcomes) alcohol use disorders (AUD) patients.
There is little information on pulmonary rehabilitation in patients with cystic fibrosis (CF) exacerbation. This study aimed to evaluate the effects of an early program lung function, muscle strength, inflammatory markers, and quality life adults CF hospitalized for In this randomized controlled trial, 19 were included intervention group 15 control group. The underwent 14 days after admission. All spirometry, one-repetition maximum tests (1RM), 6-min walk test, answered Revised Cystic...
Many studies have considered stem cell-based therapy as a treatment option for acute myocardial infarction (AMI). Paracrine signaling has been proposed an underlying mechanism, in which released cytokines and chemokines may promote angiogenesis activation of resident cells. In order to characterize this paracrine action, bone marrow mononuclear cells (BM-MNC) collected from femur adults GFP+ Wistar rats were encapsulated 1.5% sodium alginate. Animals randomized three groups: SHAM (n=3);...
Physiological and pathological left ventricular hypertrophies (LVH) are distinct processes that have differential pattern of gene expression. Based on initial stimuli, miRs expression levels can fluctuate then cause a variance their targets culminating in diverse cellular pathway activation. AIM: Here we compared between cardiac hypertrophy induced by transverse aortic constriction (TAC) physiological voluntary exercise running wheels (EXE). METHODS: Adult male Balb/c mice (12-14 weeks old)...
Background - Carotid intraplaque hemorrhage (IPH) is a marker of atheroma instability. In the present study, we evaluated potential association between serum levels pentraxin 3 (PTX3, novel vascular inflammation) and matrix metalloproteinases (MMPs) with in vivo assessment IPH by high-resolution magnetic resonance imaging (MRI). Methods Results Consecutive patients submitted to carotid endarterectomy underwent MRI; independent evaluation neurological symptoms; histological analysis...