A5063159465- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Gut microbiota and health
- Diet and metabolism studies
- Colorectal Cancer Surgical Treatments
- Hernia repair and management
- Adipose Tissue and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Anorectal Disease Treatments and Outcomes
- Neuroendocrine regulation and behavior
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Hops Chemistry and Applications
- Pelvic floor disorders treatments
- Medicinal Plants and Bioactive Compounds
- Silymarin and Mushroom Poisoning
- Virology and Viral Diseases
- Nutrition, Genetics, and Disease
- Shoulder Injury and Treatment
- Sphingolipid Metabolism and Signaling
- Plant Molecular Biology Research
- Parasitic Diseases Research and Treatment
- interferon and immune responses
- Genomics, phytochemicals, and oxidative stress
- Abdominal Surgery and Complications
APC Microbiome Institute
2019-2024
University College Cork
2019-2024
Universidad de Málaga
2021
Hospital Comarcal de Inca
2020
Pontificia Universidad Católica de Valparaíso
2016
Hospital Regional de Antofagasta
2014
Recent investigations in neuroscience implicate the role of microbial-derived metabolites, such as short-chain fatty acids (SCFAs) brain health and disease. The SCFAs acetate, propionate butyrate have pleiotropic effects within nervous system. They are crucial for maturation brain's innate immune cells, microglia, modulate other glial cells through aryl-hydrocarbon receptor. Investigations preclinical clinical models find that exert neuroprotective antidepressant affects, while also...
Background: Early life stress is a key predisposing factor for depression and anxiety disorders. Selective serotonin re-uptake inhibitors (SSRI) are frequently used as the first line of pharmacology treatment but have several negative qualities, i.e. delay or absence effectiveness side-effects. Therefore, there growing need new nutraceutical-based strategies to blunt effects adverse-life events.Objectives: This study aimed use maternal separation model in rats test efficacy fish oil dietary...
Abstract Background Polyphenols are phytochemicals that have been associated with therapeutic effects in stress-related disorders. Indeed, studies suggest polyphenols exert significant neuroprotection against multiple neuronal injuries, including oxidative stress and neuroinflammation, but the mechanisms unclear. Evidence indicates polyphenol may be mediated by activation of Nrf2, a transcription factor antioxidant cell survival responses. On other hand, stress-linked disorders, Fkbp5 is...
In mammals, Tripartite motif-containing (TRIM) proteins modulate the immune response by coordinating pro-inflammatory related processes such as antiviral restriction, cellular autophagy and inflammasome activation. fish, TRIM have been reported mainly in cyprinids (e.g., carp, zebrafish) salmonids (rainbow trout). However, their molecular mechanisms functions are still being described these animals. Our study focused on characterizing novel involved innate of gill cells from rainbow trout...
Nutrition is a crucial component for maintenance of brain function and mental health. Accumulating evidence suggests that certain molecular compounds derived from diet can exert neuroprotective effects against chronic stress, moreover improve important neuronal processes vulnerable to the stress response, such as plasticity neurogenesis. Phospholipids are naturally occurring amphipathic molecules with promising potential promote However, it unclear whether phospholipids able modulate...
In the last two decades, many sphincter preservation techniques have been proposed for treatment of anal fistula. Since 2011, our surgical team has treated fistulas by sealing them with platelet-rich fibrin (PRF). This is performed actually as an outpatient process, without anaesthesia.Patients were PRF sealant, during period June 2012-March 2017. The preparation applied in fistulous tract, no need any type anaesthesia, and so patient can go home immediately afterwards, further...
Hypertrophic protein-losing gastropathy. Ménétrier disease. A clinical caseIntroduction: disease is a rare disorder characterized by gastric foveolar hyperplasia associated with secondary protein loss.In children, this condition presented as an edematous syndrome without renal or hepatic impairment and differs from the adult form constant presence of edema spontaneous remission.It has been related to infections in most published cases, especially Cytomegalovirus (CMV) Helicobacter pylori...
Increasing scientific evidence is validating the use of dietary strategies to support and improve brain health throughout lifespan, with tailored nutritional interventions catering for specific life stages. Dietary phospholipid supplementations in early adulthood are shown alleviate some behavioral consequences associated chronic stress. This study aims explore protective effects a phospholipid-enriched buttermilk on endocrine responses induced by psychosocial stress adulthood, compare these...
Giant hiatal hernias still pose a major challenge to digestive surgeons, and their repair is sometimes highly complex task. This usually performed by laparoscopy, while the role of thoracoscopic approach has yet be clearly defined.To preoperatively detect patients with giant hernia in whom it would not safe perform laparoscopic surgery who, therefore, candidates for approach.In present study, using imaging test we simulate field vision camera working area (instrumental access) that can...
Need. The diversity of approaches proposed for the treatment complex perianal fistulas reflects fact that no method has yet been shown to be fully satisfactory. We believe successful this condition is directly proportional amount fibrous tissue can removed. Technical solution. use a kit small curettes, different thicknesses and sizes, incorporating spicules enable physician remove from fistula tract. size varying curettes them mould curves tract by deroofing shallowest deepest layers, thus...
Novel suturing technique, based on physical principles, achieves a breaking point double that obtained by conventional techniques
All fields of medicine have had to change and adapt in response the COVID-19 pandemic. In this respect, frail immunocompromised patients been particularly affected. Such are commonly treated oncology, a field that has witnessed revolution its protocols, as physicians institutions address new situation. This paper details aspects oncology affected by pandemic, areas such chemotherapy, surgery radiotherapy, together with sharp rise use telemedicine. Some these changes will probably be...