A5012310070- Tryptophan and brain disorders
- Gut microbiota and health
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- Autism Spectrum Disorder Research
- Neuroendocrine regulation and behavior
- Gastrointestinal motility and disorders
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Infant Nutrition and Health
- Iron Metabolism and Disorders
- Birth, Development, and Health
- Fatty Acid Research and Health
- GDF15 and Related Biomarkers
- Pharmacological Effects and Toxicity Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Infant Health and Development
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Biochemical effects in animals
APC Microbiome Institute
2018-2024
University College Cork
2018-2024
University of Buenos Aires
2014-2021
Consejo Nacional de Investigaciones Científicas y Técnicas
2014-2021
Wadsworth Atheneum Museum of Art
2018
Institute of Astronomy and Space Physics
2014-2015
Autism spectrum disorders (ASD) are a group of developmental disabilities characterized by impaired social interaction, communication deficit and repetitive stereotyped behaviors. Neuroinflammation synaptic alterations in several brain areas have been suggested to contribute the physiopathology ASD. Although limbic system plays an important role functions found ASD, reports on these scarce results controversial. In present study we searched medial prefrontal cortex (mPFC) hippocampus rats...
Numerous studies have emphasised the importance of gut microbiota during early life and its role in modulating neurodevelopment behaviour. Epidemiological shown that early-life antibiotic exposure can increase an individual's risk developing immune metabolic diseases. Moreover, preclinical long-term antibiotic-induced microbial disruption enduring effects on physiology, brain function However, these not investigated impact targeted depletion critical developmental windows how this may be...
Pregnancy and early life are characterized by marked changes in body microbial composition. Intriguingly, these take place simultaneously with neurodevelopmental plasticity, suggesting a complex dialogue between the microbes that inhabit gastrointestinal tract brain. The purpose of this chapter is to describe natural trajectory microbiota during pregnancy life, as well review literature available on its interaction neurodevelopment. Several lines evidence show gut interacts diet, drugs...
Astroglial cells are crucial for central nervous system homeostasis. They undergo complex morpho-functional changes during aging and in response to hormonal milieu. Ovarian hormones positively affect different astroglia parameters, including regulation of cell morphology release neurotrophic neuroprotective factors. Thus, ovarian hormone loss menopause has profound impact astroglial pathophysilogy been widely associated the process brain aging. Humanin is a secreted mitochondrial-encoded...
Recent investigations in neuroscience implicate the role of microbial-derived metabolites, such as short-chain fatty acids (SCFAs) brain health and disease. The SCFAs acetate, propionate butyrate have pleiotropic effects within nervous system. They are crucial for maturation brain's innate immune cells, microglia, modulate other glial cells through aryl-hydrocarbon receptor. Investigations preclinical clinical models find that exert neuroprotective antidepressant affects, while also...
Stress-related psychiatric disorders such as depression are among the leading causes of morbidity and mortality. Considering that many individuals fail to respond currently available antidepressant drugs, there is a need for antidepressants with novel mechanisms. Polymorphisms in gene encoding FK506-binding protein 51 (FKBP51), co-chaperone glucocorticoid receptor, have been linked susceptibility stress-related disorders. Whether this can be targeted their treatment remains largely...
The developing central nervous system is highly sensitive to nutrient changes during the perinatal period, emphasising potential impact of alterations maternal diet on offspring brain development and behaviour. A growing body research implicates gut microbiota in neurodevelopment Maternal overweight obesity period has been linked neurodevelopment, plasticity affective disorders offspring, with implications for microbial signals from gut. Here we investigate high-fat (mHFD)-induced...
The aim of this study was to determine whether early demyelination can impact behavior in young adulthood. For purpose, albino Wistar rats either sex were exposed cuprizone (CPZ) two different intoxication protocols: one group intoxicated before weaning (CPZ‐BW), from postnatal day 7 (P7) P21, through maternal milk, whereas the other after (CPZ‐AW), P21 P35. After treatment, returned a normal diet until P90 when behavioral studies performed. Both treatments produced marked corpus callosum...
Dendritic and synapse remodeling are forms of structural plasticity that play a critical role in normal hippocampal function. Neural cell adhesion molecule (NCAM) its polysialylated form (PSA-NCAM) participate neurite outgrowth formation plasticity. However, it remains unclear whether they contribute to dendritic retraction synaptic disassembly. Cultured neurons exposed glutamate (5 µM) showed reduced MAP-2 (+) area the absence neuronal death 24 h after insult. Concomitantly, loss, revealed...
Abstract Background Autism spectrum disorders (ASD) are synaptopathies characterized by area-specific synaptic alterations and neuroinflammation. Structural adhesive features of hippocampal synapses have been described in the valproic acid (VPA) model. However, neuronal microglial contribution to pattern its time-course appearance is still unknown. Methods Male pups born from pregnant rats injected at embryonic day 10.5 with VPA (450 mg/kg, i.p.) or saline (control) were used. Maturation,...
Abstract Atypical connectivity between brain regions and altered structure of the corpus callosum (CC) in imaging studies supports long‐distance hypoconnectivity hypothesis proposed for autism spectrum disorder (ASD). The aim this study was to unveil CC ultrastructural cellular changes employing valproic acid (VPA) rat model ASD. Male Wistar rats were exposed VPA (450 mg/kg i.p.) or saline (control) during gestation (embryonic day 10.5), maturation, exploration, social behavior subsequently...
Prenatal iron deficiency (pID) has been described to increase the risk for neurodevelopmental disorders such as autism and schizophrenia; however, precise molecular mechanisms are still unknown. Here, we utilized high-throughput MS examine proteomic effects of pID in adulthood on rat frontal cortex area (FCA). In addition, FCA proteome was examined following risperidone treatment adolescence see if these could be prevented. We identified 1501 proteins which 100 were significantly...