A5101798251- Soil Geostatistics and Mapping
- RNA Interference and Gene Delivery
- Geochemistry and Geologic Mapping
- Advanced biosensing and bioanalysis techniques
- Soil and Unsaturated Flow
- Remote Sensing in Agriculture
- Soil Moisture and Remote Sensing
- Spectroscopy and Chemometric Analyses
- Virus-based gene therapy research
- Indoor and Outdoor Localization Technologies
- Hydraulic Fracturing and Reservoir Analysis
- Immune Cell Function and Interaction
- Underwater Vehicles and Communication Systems
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Landslides and related hazards
- Soil and Land Suitability Analysis
- Leaf Properties and Growth Measurement
- Soil Carbon and Nitrogen Dynamics
- CAR-T cell therapy research
- Hydrocarbon exploration and reservoir analysis
- Advanced SAR Imaging Techniques
- Lipid Membrane Structure and Behavior
- RNA Research and Splicing
- Synthetic Aperture Radar (SAR) Applications and Techniques
Nanjing University of Information Science and Technology
2018-2025
Zhejiang University
2024-2025
Zhejiang Pharmaceutical College
2025
Second Affiliated Hospital of Zhejiang University
2024
China University of Petroleum, Beijing
2020
China University of Mining and Technology
2015-2017
National Administration of Surveying, Mapping and Geoinformation of China
2015-2016
Abstract Fully targeted mRNA therapeutics necessitate simultaneous organ-specific accumulation and effective translation. Despite some progress, delivery systems are still unable to fully achieve this. Here, we reformulate lipid nanoparticles (LNPs) through adjustments in material structures compositions systematically the pulmonary hepatic (respectively) distribution expression. A combinatorial library of degradable-core based ionizable cationic lipids is designed, following by optimisation...
Unlocking the full potential of mRNA immunotherapy necessitates targeted delivery to specific cell subsets in spleen. Four-component lipid nanoparticles (LNPs) utilized numerous clinical trials are primarily limited hepatocyte and muscular targeting, highlighting imperative demand for simplified non-liver systems. Herein, we report rational design one-component ionizable cationic lipids selectively deliver spleen T cells with high efficacy. Unlike tertiary amine-based involved LNPs, proposed...
Abstract Unlocking the full potential of mRNA immunotherapy necessitates targeted delivery to specific cell subsets in spleen. Four‐component lipid nanoparticles (LNPs) utilized numerous clinical trials are primarily limited hepatocyte and muscular targeting, highlighting imperative demand for simplified non‐liver systems. Herein, we report rational design one‐component ionizable cationic lipids selectively deliver spleen T cells with high efficacy. Unlike tertiary amine‐based involved LNPs,...
Development of mRNA therapeutics necessitates targeted delivery technology, while the clinically advanced lipid nanoparticles face difficulty for extrahepatic delivery. Herein, we design highly branched poly(β-amino ester)s (HPAEs) efficacious organ-selective through tailoring their chemical compositions and topological structures. Using an "A2+B3+C2" Michael addition platform, a combinatorial library 219 HPAEs with varied backbone structures, terminal groups, branching degrees are...
Abstract mRNA therapeutics have shown great potential for a broad spectrum of disease treatment. However, the challenges mRNA's inherent instability and difficulty in cellular entry hindered its progress biomedical field. To address barriers deliver to cells interest, various delivery systems are designed. Among these, lipid nanoparticles (LNPs) stand out as most extensively used systems, particularly following clinical approvals corona virus 2019 (COVID‐19) vaccines. LNPs comprised...
The progress of mRNA therapeutics underscores the imperative demand for development targeted delivery systems. While cationic polymers hold promise as genetic vectors, their poor in vivo efficacy and numerous variants highlight urgent need a universal functionalization strategy to bolster capabilities. Here, we present versatile transform low‐cost commercial into phospholipidated alkylated (PAPs), enabling efficient organ‐selective vivo. This straightforward post‐functionalization method can...
The progress of mRNA therapeutics underscores the imperative demand for development targeted delivery systems. While cationic polymers hold promise as genetic vectors, their poor in vivo efficacy and numerous variants highlight urgent need a universal functionalization strategy to bolster capabilities. Here, we present versatile transform low‐cost commercial into phospholipidated alkylated (PAPs), enabling efficient organ‐selective vivo. This straightforward post‐functionalization method can...
The measurement of soil total nitrogen (TN) by hyperspectral remote sensing provides an important tool for restoration programs in areas with subsided land caused the extraction natural resources. This study used local correlation maximization-complementary superiority method (LCMCS) to establish TN prediction models considering relationship between spectral reflectance (measured ASD FieldSpec 3 spectroradiometer) and based on curves samples collected from which is determined synthetic...
Many factors influence the positioning performance in WLAN RSSI fingerprinting systems, and summary of these is an important but challenging job. Moreover, impact analysis on nonalgorithm significant to system application quality control little research has been conducted. This paper analyzes summarizes potential by using Ishikawa diagram considering radio signal transmitting, propagating, receiving, processing. A simulation platform was developed facilitate experiment, classifies into...
. Due to the regular revisit periods of SAR platforms and decorrelation images, estimation ground deformation retrieved from a particular dataset may be low resolution in both spatial temporal dimensions. To enhance sampling rates estimation, multiplatform combination strategy is proposed, based on Multi-Temporal InSAR (MTInSAR) technique Same Name target point Pairs (SNPs) approach. The has been tested applied Cangzhou area, which suffered subsidence due mainly groundwater extraction....
Accurate observation of plant biomass is crucial for estimation global carbon stocks and ecosystem productivity, optical spectroscopy technology represents a potential solution. However, the water content limits accuracy, due to its contribution spectral characteristics. In this study, we used water-based spectrum correction (PSC) method decrease influence content, models were developed by combining PSC multiple linear regression (MLR) methods. The data 387 tree leaves acquired using an ASD...
Abstract The lower limit of reservoir physical properties is an important parameter for identifying the and determining effective thickness in reserve evaluation, it also basis selecting test interval oilfield exploration development. In view basicity necessity studying properties, related determination methods have been research hotspots engineers. Existing results show that determined under established process technology conditions, but changes with development oil gas extraction...