Gliomas are one of the most aggressive and treatment-resistant types human brain cancer. Identification evaluation anticancer properties compounds found in plants, such as naringenin (N) 8-prenylnaringenin (8PN), among promising applications glioma therapy. The prenyl group seems to be crucial activity flavones, since it may lead enhanced cell membrane targeting thus increased intracellular activity. It should noted that 8PN content hop cones is 10 100 times lower compared other flavonoids,...

Coumarins are a structurally diverse group of natural substances derives from plants that display host bioactivities. In this paper, we will introduce the reader to coumarins and their applications as medicinal substances. The great diversity in courmarin structure be discussed along with extensive use pharmaceutical agents. wide range antimicrobial activity antifungal antiviral agents addressed. Other properties such role neuroprotection, anticancer, antioxidants also reviewed.

The level of balance can play an essential role in a soldier's performance. For Special Forces soldier, the footwear used or extra weight may be important factors affecting their during combat operations trainings. Therefore, purpose study was to assess static Operators and determine influence select elements uniform equipment on levels. group consisted 37 Polish Operators. To balance, Romberg test three variants (barefoot, with shoes, helmet, vest). measurements were made using AMTI...

Rheumatoid arthritis is a chronic, autoimmune connective tissue disease. In addition to joint involvement, extra-articular changes and organ complications also occur in the course of Untreated disease leads disability premature death. Therefore, it important recognise begin treatment early. Based on presence rheumatoid factor antibodies against citrullinated peptides, we can distinguish two forms disease: seropositive seronegative. Research continues elucidate mechanisms onset disease, as...

Prenatal alcohol exposure causes growth impairment and a wide range of developmental, physical, cognitive disorders in children, collectively referred to as fetal spectrum (FASDs). In the course FASDs, abnormalities can also affect eating behavior nutritional status, but these problems have received little attention. Therefore, aim our study was determine levels hormones involved action hypothalamic–pituitary–adrenal axis: proopiomelanocortin (POMC), cortisol, adrenocorticotropic hormone...

A deeper insight into the mechanisms responsible for athlete performance that may serve as specific and detailed training indicators is still desired, because conventionally used biomarkers provide limited information about adaptive processes occur during exercise. The objective of our study was to assess insulin-like growth factor 1 receptors (IGF1R) gene expression evaluate plasma concentration selected microRNAs (miRNAs) a 10-week period (sampling times: week 1, 4, 7, 10) in group 12...

The aim of the study was to investigate effect Trastuzumab on MCF-7 and CRL-2314 breast cancer cell lines. Additionally, an attempt made optimize magnetic resonance spectroscopy (MRS) for culture studies, with particular emphasis impact treatment Trastuzumab. research materials included examined response these lines clinical imaging (MRI) system, OPTIMA MR360 manufactured by GEMS, a field induction 1.5 T, used. Due nature tested objects, their size shape, it necessary design manufacture...

Summary The aim of our paper was the examination various procedures extraction and purification methods on yield atropine scopolamine in Datura innoxia extracts determined by high-performance thin-layer chromatography (HPTLC). In experiments, following were used: percolation, ultrasound-assisted (USAE) at temperatures, microwave-assisted (MASE). highest yields obtained method aqueous acetic acid or tartaric used as extractants. Crude D. herb purified use methods: solid-phase...

Along with the significant elongation in average life expectancy of patients cystic fibrosis (CF), there are still discrepancies height, weight, and body mass index (BMI) compared to controls without CF. The correlation between hormones that regulate appetite fat may be an additional factor weight loss or poor gain CF patients. Our objective was estimate serum concentrations leptin neuropeptide Y as well assess correlations studied clinical parameters Leptin after overnight fast were...

The use of matrix solid-phase dispersion (MSPD) was tested to extract some coumarins (umbelliferone, xanthotoxin, isopimpinellin, bergapten, and pimpinellin) from Pimpinella roots. method compared with liquid—solid extraction methods (LSE) such as accelerated solvent (ASE), ultrasound-assisted (USAE) Soxhlet followed by (SPE). Several methanol concentrations temperature conditions were examined during the techniques. analysis performed high-performance liquid chromatography diode array...

Obesity in childhood is associated with several steroid changes, which result from excess body mass. The aim of this study was to evaluate metabolism children obesity compared those normal weight, especially relation sex and puberty progress. We analyzed the clinical data 191 children, aged between 5 18 years, 115 affected (64 girls 51 boys) 76 unaffected (35 41 by obesity. Routine assessment pubertal stage evaluation based upon Tanner's scale were performed. In addition, impact puberty,...

Isoxanthohumol (2) and its 4'-O-monoacylated (3) 7,4'-O-diacetylated (4) derivatives were synthesized evaluated in vitro for their cytotoxic activity against several cancer cell lines of various origins: MCF-7 (breast), A549 (lung), MESSA (uterine sarcoma), LoVo (colon), drug-resistant human cells (MESSA/DX LoVo/DX), glioblastoma (U-118 MG), also towards the non-cancerous line MCF-10A (normal breast cells). An antiproliferative assay indicates that 7,4'-di-O-acylisoxanthohumol has similar...

Alterations in glucocorticoid metabolism may contribute to the development of obesity and insulin resistance (IR). Obesity turn affects androgen balance. The peripheral steroids is equally an important determinant their bioavailability activity. aim this study was evaluate steroid obese children define which enzyme alterations are associated with IR. Clinical characteristics anthropometric measurements were determined 122 adolescents (72 girls, 50 boys) aged 8 – 18 years. 26 them (21.3%)...

Neural tube defects are abnormalities that can occur in the brain (anencephaly, encephalocele), spine (spina bifida, myelomeningocele, myelodysplasia), both and (craniorachischisis) or spinal column of a developing embryo present at birth. They arise when neural tube, embryonic precursor cord, fails to close during neurulation. Many cases worldwide each year more than 300,000 newborn babies significant cause infant death lifelong disability. Most preventable. The prevalence these has...

Cystic fibrosis (CF) is a life-threatening inherited disease related to mutation in the CFTR gene, that leads serious health complications such as chronic pulmonary infections, pancreatic insufficiency, dysfunction of sweat glands and reproductive system. For first time, we have described profile corticosterone androgen metabolites urine, well activity enzymes involved steroid genesis metabolism people with CF, using gas chromatography/mass spectrometry. A significant reduction excretion...

Rising prevalence of obesity has become an important impulse to investigate basic mechanisms involved in regulating the energy balance. It is widely accepted that steroids are potent factors affecting glucose, fat, and protein metabolism. Our study was aimed analyze differences total amount selected enzymes implicated steroid metabolism a group children suffering from those with normal weight, further subdivided according sex pubertal stage. Data were obtained 187 Caucasian adolescents,...

Cystic fibrosis (CF) is an inherited syndrome associated with a mutation in cystic transmembrane conductance regulator gene, composed of exocrine gland dysfunction involving multiple systems that may result chronic respiratory infections, pancreatic enzyme deficiency, and developmental disorders. Our study describes for the first time urinary profile glucocorticoid metabolites activity enzymes involved development metabolism cortisol patients CF, using gas chromatography/mass spectrometry...