Background. Neurological disorders like Alzheimer’s disease (AD) and Parkinson’s (PD) manifest through gradually deteriorating cognitive functions. An encouraging strategy for addressing these involves the inhibition of precursor-cleaving enzyme 1 (BACE1). Objectives. In current research, a virtual screening technique was employed to identify potential BACE1 inhibitors among selected herbal isolates. Methods. This study evaluated 79 flavonoids, anthraquinones (AQs), cinnamic acid derivatives...

Investigating the relationship between severity of coronary artery disease and inflammatory factors ‎MHR, PHR, NHR, IL-25

As the SARS-CoV-2 (COVID-19) pandemic spreads rapidly, there is need for a diagnostic test with high accuracy to detect infected individuals especially those without symptoms. Real-time polymerase chain reaction (RT-PCR) common molecular diagnosing SARS-CoV-2. If some factors are not taken into consideration when performing this test, it can have relatively large number of false negative results. In article, we discuss important considerations that could lead reduction.
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Wound healing is a complex process orchestrated by interactions between variety of cell types, including keratinocytes, fibroblasts, endothelial cells, inflammatory and bioactive factors such as extracellular matrix (ECM) components, growth factors, cytokines. Chronic wounds exhibit delayed proliferative phase initiation, reduced angiogenesis, impaired ECM synthesis, persistent response. are one the main challenges to healthcare system worldwide, with high cost for medical services. Hence,...

Abstract Objectives Down-regulation of miRNA-7 is correlated with over-expression IRS-1 and IRS-2 proteins, the upstream regulators IGF-1R/Akt pathway, in glioblastoma cells. In this study, effect on expression sensitivity U373-MG cells to erlotinib was explored. Methods After transfection, mRNAs measured by RT-qPCR. Trypan blue assay used assess cell proliferation. The effects erlotinib, alone combination, survival apoptosis were using MTT ELISA death assay, respectively. Key findings Our...

Background: Despite the dramatic efficacy of ABT-737, a large percentage cancer cells ultimately become resistance to this drug. Evidences show that over-expression Mcl-1 is linked ABT-737 in NSCLC cells. The aim study was investigate effect miRNA-101 on expression and sensitivity A549 ABT-737. Methods: After transfection, mRNA levels were quantified by RT-qPCR. Trypan blue staining used explore cell growth. cytotoxic effects alone combination, measured using MTT assay. drugs combination...

Ferula species have diverse biological functions. This study set out to investigate the anti-proliferative effects of methanolic extract F. pseudalliacea against human colon cancer HCT-116 cell line. Cytotoxic on cells was estimated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay. Real-time polymerase chain reaction (PCR) and Western blot were employed analyze BAX Bcl2 expression. Cell cycle analysis apoptosis conducted using flowcytometry Annexin V/ propidium iodide (PI)...

Over-expression of anti-apoptotic proteins such as Bcl-2 and Mcl-1 is associated with resistance to chemotherapeutic agents fludarabine. Moreover, an inverse relationship between miRNA-15a levels expression has been observed in CLL patients. In this study, the effect on apoptosis sensitivity cells fludarabine was investigated.After treatments, were quantified by RT-qPCR. Trypan blue assay used explore effects cell proliferation. The cytotoxicity measured using MTT combination index analysis....

Objectives. Chemotherapy is considered to be essential in the treatment of patients with colorectal cancer (CRC), but drug resistance reduces its efficacy. Many advanced CRC eventually show 5-fluorouracil (5-FU) therapy. Synergistic and potentiating effects combination therapy, using herbal chemical drugs, can improve patients’ response. Zerumbone (ZER), which derived from ginger, has been studied for growth inhibitory function various types cancer. Methods. The cytotoxic ZER 5-FU alone...

Background: Interactions of drugs with DNA and proteins may modify their biological activities conformations, which effect transport metabolism drugs. Objective: In this study the interaction anticancer drug regorafenib (REG) calf thymus-DNA (ct-DNA) human serum albumin (HSA) has been investigated Methods: Hence, for first time, it was discovered between REG HSA using multi-spectroscopic, zeta potential measurements molecular docking method. Results Discussion: displacement studies showed...

<title>Abstract</title> Colorectal cancer (CRC) presents a significant global health challenge, which demands advanced molecular understanding for personalised treatments. Molecular profiling has revealed biomarkers crucial prognosis, treatment response, and targeted therapies. This study explores the role of native plant compounds, using bioinformatics experimental assays to identify potential CRC-specific therapeutic targets. A drug-target network analysis identified four proteins (ANG,...

The present study aimed to evaluate the synergic effects of combination therapy on 5-fluorouracil (5-FU) resistance-cancer-associated fibroblasts (CAFs) treatment. Chemotherapy resistance is an important challenge in colorectal cancer (CRC) eradication attention tumor microenvironment (TME) very important. CAFs TME play essential role chemoresistance and relapse. Additionally, many patients with advanced CRC show 5-FU therapy. Anti-tumorigenic activities ZER, a chemopreventive compound...

Background: MicroRNAs (miRNAs) are small noncoding RNAs (containing approximately 22 nucleotides), which modulate and control the expression of target genes by binding them. MiRNAs play a crucial role in tumorigenesis. Thus, alterations level miRNAs key pathobiology numerous cancers. In this research, MicroRNA-1290 (miR1290) its THBS1 DKK3 were evaluated colorectal cancer (CRC) patients. Methods: This case-control study was carried out on 144 paraffin-embedded tissue samples CRC adjacent...

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