A5041335841- Gold and Silver Nanoparticles Synthesis and Applications
- Protein Interaction Studies and Fluorescence Analysis
- Nonlinear Optical Materials Research
- Cultural Heritage Materials Analysis
- Analytical Chemistry and Chromatography
- Crystallization and Solubility Studies
- Ancient Mediterranean Archaeology and History
- Aldose Reductase and Taurine
- Spectroscopy Techniques in Biomedical and Chemical Research
- Free Radicals and Antioxidants
- Classical Antiquity Studies
- Building materials and conservation
- Conservation Techniques and Studies
- Nanocluster Synthesis and Applications
- Analytical Methods in Pharmaceuticals
- X-ray Diffraction in Crystallography
- Spectroscopy and Chemometric Analyses
- Crystallography and molecular interactions
- Metal complexes synthesis and properties
- Clay minerals and soil interactions
- Drug Solubulity and Delivery Systems
- Computational Drug Discovery Methods
- Quantum Dots Synthesis And Properties
- Nanoparticle-Based Drug Delivery
- Phenothiazines and Benzothiazines Synthesis and Activities
University of Modena and Reggio Emilia
2014-2025
Bridge University
2023
Charles University
2023
Universidade Nove de Julho
2008-2014
University of Pisa
1999
University of Scranton
1999
Drug repositioning (o repurposing) has become one of the most popular and successful strategies to reduce failures typically associated with drug discovery [...]
Starting from the inhibitory activity of flavonoid Quercetin, a series 4H-1-benzopyran-4-one derivatives was synthesized and tested for inhibition aldose reductase, an enzyme involved in appearance diabetic complications. Some compounds obtained display similar to that Sorbinil but are more selective than Quercetin with respect closely related enzyme, aldehyde also possess antioxidant activity. Remarkably, these higher pKa values carboxylic acids, characteristic which could make...
The objective of the current research was to develop a liquid chromatography-MSn (LC-MSn) methodology for determination free cortisol and its 15 endogenous metabolites (6β-hydroxycortisol, 20α-dihydrocortisol, 20α-dihydrocortisone, 20-β-dihydrocortisol, 20β-dihydrocortisone, prednisolone, cortisone, α-cortolone, β-cortolone, allotetrahydrocortisol, 5α-dihydrocortisol, tetrahydrocortisol, allotetrahydrocortisone, 5β-dihydrocortisol, tetrahydrocortisone) in human urine. Due optimal...
Diabetes is often accompanied by several long-term complications such as neuropathy, nephropathy, retinopathy, cataract and angiopathy; their occurrence has been linked to the modification of physiological levels glycaemia. Several interrelated metabolic pathways have implicated in toxic effects glucose; polyol pathway was one first considered. However, while diabetic animal models inhibitors aldose reductase (ALR2, enzyme this pathway) seem be active, 16 years clinical trials, based mainly...
Discovering new materials to aid in the therapeutic delivery of drugs is high demand. PLGA, a FDA approved polymer, well known literature form films or nanoparticles that can load, protect, and deliver drug molecules; however, its incompatibility with certain (due hydrophilicity charge repulsion interactions) limits use. Combining PLGA other polymers such as polycaprolactone safe positively-charged molecules, chitosan, has been sought after make hybrid systems are more flexible terms loading...