A5023735521- Medical History and Innovations
- History of Medical Practice
- History of Medicine Studies
- Signaling Pathways in Disease
- PARP inhibition in cancer therapy
- RNA Research and Splicing
- Facial Trauma and Fracture Management
- Organ and Tissue Transplantation Research
- Ophthalmology and Visual Health Research
- Psychoanalysis and Psychopathology Research
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Quantum Chromodynamics and Particle Interactions
- Ovarian cancer diagnosis and treatment
- Child and Adolescent Health
- Atomic and Molecular Physics
- Neurological disorders and treatments
- Cervical Cancer and HPV Research
- Spaceflight effects on biology
- Parkinson's Disease and Spinal Disorders
- Diet and metabolism studies
- Microtubule and mitosis dynamics
- Diversity and Career in Medicine
- Nuclear physics research studies
- Muscle Physiology and Disorders
National and Kapodistrian University of Athens
2002-2024
Northwestern University
2010-2015
University of Illinois Chicago
2004-2013
Jesse Brown VA Medical Center
2010-2013
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
2010
Institute of Nuclear and Particle Physics
2002
The Schlafen (SLFN) family of proteins includes several mouse and human members. There is emerging evidence that members this are involved in important functions, such as the control cell proliferation, induction immune responses, regulation viral replication. These span across all species with great diversity, 10 murine 5 isoforms. Recent work has established SLFN regulated by interferons (IFNs). Several Slfn genes were shown to be induced classical interferon-stimulated genes, suggests...
IFNα exerts potent inhibitory activities against malignant melanoma cells in vitro and vivo, but the mechanisms by which it generates its antitumor effects remain unknown. We examined of interferon α (IFNα) on expression human members Schlafen (SLFN) family genes, a group cell cycle regulators that mediate growth-inhibitory responses. Using quantitative RT-real time PCR, we found detectable basal all different SLFN genes (SLFN5, SLFN11, SLFN12, SLFN13, SLFN14), primary normal melanocytes,...
We provide evidence that human SLFN5, an interferon (IFN)-inducible member of the Schlafen (SLFN) family proteins, exhibits key roles in controlling motility and invasiveness renal cell carcinoma (RCC) cells. Our studies define mechanism by which this occurs, demonstrating SLFN5 negatively controls expression matrix metalloproteinase 1 gene (MMP-1), MMP-13, several other genes involved control malignant motility. Importantly, our data establish correlates with a better overall survival large...
Insulin-like growth factor-1 (IGF-1) isoforms are expressed via alternative splicing. Expression of the minor isoform IGF-1Eb [also known as mechano-growth factor (MGF)] is responsive to cell stress. Since IGF-1 differ in their E-domain regions, we interested determining biological function MGF E-domain. To do so, a synthetic peptide analog was used gain mechanistic insight into actions Treatment H9c2 cells indicated rapid cellular uptake mechanism that did not involve receptor activation...
Mathieu Jaboulay (1860-1913) was an inventor in vascular and general surgery. He fabricated many new surgical techniques instruments such as method for sutures, anastomotic button, amputation, known also hemipelvectomy. In addition, he a pioneer heterologous transplantation sympathectomy. found death suddenly terrible train crash. reputable Professor of Surgery at Lyon Faculty Medicine with prestigious students
Eugène Louis Doyen (1859-1916) is considered as the reformer of French surgery at end 19th and early 20th century. Although he had a short life, dying age 57, left his mark in history medicine especially surgery, not only because introduced many new medical instruments but also for innovative idea to introduce cinematography surgical education, which crucial until today education every surgeon world.
Backround. Professor Paul Jules Tillaux (1834–1904) is considered to be a leading figure in the field of surgery during 19th century. Methods. Although his work mostly linked orthopedic operations, he contributed lot ophthalmology and ophthalmic too. Results. In addition, masterpieces on topographical anatomy clinical became gold standard treatises era.
Introduction: The aim of the present study is to an historical overview innovations in ocular surgery introduced by very important surgeon, but mainly unknown, Philip Henry Mules (1843–1905).Methods: Mules’ evisceration operation and ptosis operation. He also invented surgical instruments such as scoop, repository, enucleation scissors. was interested infection.Results: Many are still use.Conclusions: (1843–1905) a respectable English ophthalmologist, who despite his short life, only...
Professor William Macewen (1848-1924) is one of the most important figures in world’s surgery during 18th and early 19th century. He managed to provide numerous innovative techniques instruments various fields such as general surgery, orthopedic neurosurgery, thoracic surgery. His innovations had a great impact after his time constituted fundaments for further surgical developments. also was pioneer clinical photography with creation huge archive. During career, he received many honors.
Although Frank Hartley (1856-1913) was mostly known as the deviser of method bisecting ganglion trigeminal nerve within skull for relief facial neuralgia, it should be noted that he had also done very important work in surgical treatment goiter which neglected at his times but later followed by successors. Furthermore, interest clubfoot and exstrophy bladder.
Edward Hickling Bradford (1848-1926) is considered as 1 of the most important figures in American and world orthopedics during 19th early 20th century. His teaching ability, his gifted surgical skills innovations attracted interest orthopedic’s community gave him a long lasting reputation. But all he founder pediatric America.