A5014458797- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Fuel Cells and Related Materials
- Heart Failure Treatment and Management
- Global Cancer Incidence and Screening
- Transplantation: Methods and Outcomes
- Congenital Heart Disease Studies
- Schizophrenia research and treatment
- Blood Pressure and Hypertension Studies
- Metabolism, Diabetes, and Cancer
- Cardiovascular Function and Risk Factors
- Central Venous Catheters and Hemodialysis
- Hearing Loss and Rehabilitation
- Colorectal Cancer Screening and Detection
- Electronic Health Records Systems
- Diabetes Treatment and Management
- Total Knee Arthroplasty Outcomes
- Machine Learning in Healthcare
- Organ Transplantation Techniques and Outcomes
- LGBTQ Health, Identity, and Policy
- Dental Health and Care Utilization
- Hydraulic and Pneumatic Systems
- PI3K/AKT/mTOR signaling in cancer
- Anesthesia and Pain Management
- Economic and Financial Impacts of Cancer
University of Florida Health
2019-2024
University of Florida
2002-2024
Florida College
2023-2024
UF Health Cancer Center
2019-2023
Medical College of Wisconsin
2022
University of Chicago
2016-2017
The Alfred Hospital
2014
University of Illinois Urbana-Champaign
2008-2010
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
2008-2010
Jesse Brown VA Medical Center
2009-2010
IFNα exerts potent inhibitory activities against malignant melanoma cells in vitro and vivo, but the mechanisms by which it generates its antitumor effects remain unknown. We examined of interferon α (IFNα) on expression human members Schlafen (SLFN) family genes, a group cell cycle regulators that mediate growth-inhibitory responses. Using quantitative RT-real time PCR, we found detectable basal all different SLFN genes (SLFN5, SLFN11, SLFN12, SLFN13, SLFN14), primary normal melanocytes,...
After total knee arthroplasty (TKA), hospitalization may be shortened by allowing patients to return home with a continuous femoral nerve block (CFNB). This study quantified the costs for 10 TKA receiving ambulatory CFNB versus matched cohort of who received only during hospitalization.We examined medical records (n = 125) underwent unilateral, primary, tricompartment postoperative 1 surgeon at one institution in an 18-month period beginning January 2004. Each discharged (cases) was patient...
Abstract Purpose: Statins are pharmacologic inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase with potent regulatory effects on cholesterol biosynthesis in vitro and vivo. There is accumulating evidence that, beyond their cholesterol-lowering properties, statins inhibit cell proliferation promote apoptosis malignant cells vitro, but mechanisms by which they generate such responses remain to be defined. Experimental Design: Combinations experimental approaches were used,...
The precise STAT-regulated gene targets that inhibit cell growth and generate the antitumor effects of Type I interferons (IFNs) remain unknown. We provide evidence IFNs regulate expression Schlafens (SLFNs), a group genes involved in control cycle progression inhibitory responses. Using cells with targeted disruption different STAT proteins and/or p38 MAP kinase, we demonstrate IFN-dependent distinct Schlafen is differentially regulated by complexes kinase pathway. also for key functional...
AMPK is a cellular energy sensor that negatively regulates the mTOR signaling pathway. As plays critical roles in cell growth and tumorigenesis of renal carcinoma (RCC), we examined whether exogenous induction activity exhibits inhibitory effects on survival cells. Activation by AICAR resulted potent suppressive RCC growth, while combinations with statins were inducers apoptosis such The from inhibition its effectors, resulting activity. Similar results obtained when metformin examined....
Background Lesbian, gay, bisexual, and transgender (LGBT) cancer patients experience substantial health disparities, including poorer overall lower satisfaction with their care than heterosexual cisgender counterparts, which may be due in part to a lack of culturally competent providers. To address these web‐based LGBT cultural competency training tailored oncologists was developed by an interdisciplinary team scientists, survivors, experts, oncologists, web designer, instructional designer....
Abstract The histone methyltransferase EZH2 is required for B and T cell development; however, the molecular mechanisms underlying this requirement remain elusive. In a murine model of lymphoid-specific deficiency we found that was proper development adaptive, but not innate, lymphoid cells. adaptive cells prevented premature expression Cdkn2a consequent stabilization p53, an effector pre–Ag receptor checkpoints. Deletion in EZH2-deficient lymphocytes p53 stabilization, extended lymphocyte...
Despite advances in cancer screening, late-stage diagnosis is still a major cause of morbidity and mortality the United States. In this study, we aim to understand demographic geographic factors associated with receiving (LSD) lung, colorectal, breast, or cervical cancer. (1) Methods: We analyzed data patients between 2016 2020 from Florida Cancer Data System (FCDS), statewide population-based registry. To investigate correlates LSD, estimated multi-variable logistic regression models for...
Human papillomavirus (HPV) causes 99.7% of cervical cancer cases. Cervical is preventable through early detection via HPV testing. However, the number women screened for has not increased in last several years. Lower screening rates among living high poverty and social vulnerability areas, Black women, with chronic co-morbidities (e.g., type 2 diabetes (T2D)) are associated their higher mortality rates. When screened, more likely to be diagnosed at later stages die from cancer....
Abstract Background Improving hypertension control is a public health priority. However, consistent identification of uncontrolled using computable definitions in electronic records (EHR) across systems remains uncertain. Methods In this retrospective cohort study, we applied two to the EHR data identify patients with controlled and evaluate differences characteristics, treatment, clinical outcomes between these patient populations. We included adult (≥ 18 years) (based on either ICD-10...
Polypharmacy and frailty are correlated in Persons Living with HIV (PLWH) the United States, but little is known about their correlation resource-limited settings. Our cross-section study evaluated between polypharmacy among Thai 324 virally suppressed PLWH 132 uninfected patients aged ≥50 March 2016 April 2017. The primary predictor was number of patient-reported non-antiretroviral therapy (ART) medications. outcome having additional domain five Fried phenotype domains (0 = normal, 1-2...
BackgroundAn important step in integrating dental and medical care is improving understanding of the frequency characteristics practitioners who conduct health risk assessments (HRAs).MethodsFrom September 2017 through July 2018, active dentist hygienist members South Atlantic region The National Dental Practice-Based Research Network (N = 870) were invited to participate a survey evaluating their HRA practices (screening, measuring, discussing, referring patients) for 6 conditions (obesity,...
We sought to examine the extent which body mass index (BMI) was available in electronic health records for Florida Medicaid recipients aged 5 18 years taking Second-Generation Antipsychotics (SGAP). also illustrate how clinical data can be used identify children most at-risk SGAP-induced weight gain, cannot done using process-focused measures.
Improving hypertension control is a public health priority. However, consistent identification of uncontrolled using computable definitions in electronic records (EHR) across systems remains uncertain.
This is the second installment in colorectal cancer prevention series. article intended for adults who fall within recommended age range (45 to 75 years old) screening. aims provide up-to-date information about several approved options available Written by Melissa J. Vilaro, Valeria Westring, Jennifer Woodard, Samara Purvis, LaTrina Massey, and Wendy Wood, published UF/IFAS Department of Family, Youth Community Sciences, July 2024.