A5016357430- Spinal Cord Injury Research
- Veterinary Orthopedics and Neurology
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Zebrafish Biomedical Research Applications
- Neuroscience of respiration and sleep
- Transcranial Magnetic Stimulation Studies
- Musculoskeletal pain and rehabilitation
- Cerebral Palsy and Movement Disorders
- Robotic Locomotion and Control
- Motor Control and Adaptation
- Erythropoietin and Anemia Treatment
- Neurogenetic and Muscular Disorders Research
- Vestibular and auditory disorders
- Muscle activation and electromyography studies
- Muscle Physiology and Disorders
- Nuclear Structure and Function
- Eating Disorders and Behaviors
- Genetics and Physical Performance
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hemispheric Asymmetry in Neuroscience
- Human-Animal Interaction Studies
- Adipose Tissue and Metabolism
- Cardiomyopathy and Myosin Studies
- Muscle metabolism and nutrition
Université de Sherbrooke
2020-2024
Université Jean Monnet
2019-2024
Centre Hospitalier Universitaire de Saint-Étienne
2022-2024
Centre Hospitalier Universitaire de Sherbrooke
2023-2024
Health Sciences Centre
2021-2023
Centre Hospitalier Territorial de Nouvelle-Calédonie
2023
Université Claude Bernard Lyon 1
2018-2022
Laboratoire Interuniversitaire de Biologie de la Motricité
2017-2022
Université Savoie Mont Blanc
2017-2018
Nantes Université
2017-2018
Abstract When the foot dorsum contacts an obstacle during locomotion, cutaneous afferents signal central circuits to coordinate muscle activity in four limbs. Spinal cord injury disrupts these interactions, impairing balance and interlimb coordination. We evoked reflexes by electrically stimulating left right superficial peroneal nerves before after two thoracic lateral hemisections placed on opposite sides of at 9‐ 13‐week interval seven adult cats (4 males 3 females). recorded reflex...
Following incomplete spinal cord injury in animals, including humans, substantial locomotor recovery can occur. However, functional aspects of locomotion, such as negotiating obstacles, remains challenging. We collected kinematic and electromyography data 10 adult cats (5 males, 5 females) before at weeks 1-2 7-8 after a lateral mid-thoracic hemisection on the right side while they negotiated obstacles three different heights. Intact always cleared without contact. At hemisection,...
During locomotion, cutaneous reflexes play an essential role in rapidly responding to external perturbation, for example, prevent a fall when the foot contacts obstacle. In cats and humans, involve all four limbs are task- phase modulated generate functionally appropriate whole-body responses.
Most previous studies investigated the recovery of locomotion in animals and people with incomplete spinal cord injury (SCI) during relatively simple tasks (e.g., walking a straight line on horizontal surface or treadmill). We know less about after SCI left-right asymmetric conditions, such as turning stepping along circular trajectories. To investigate this, we collected kinematic electromyography data split-belt at different speed differences before right thoracic lateral hemisection nine...
Spinal sensorimotor circuits interact with supraspinal and peripheral inputs to generate quadrupedal locomotion. Ascending descending spinal pathways ensure coordination between the forelimbs hindlimbs. cord injury (SCI) disrupts these pathways. To investigate control of interlimb hindlimb locomotor recovery, we performed two lateral thoracic hemisections on opposite sides (right T5-T6 left T10-T11) at an interval approximately months in eight adult cats. In three cats, was transected...
Coordinating the four limbs is an important feature of terrestrial mammalian locomotion. When foot dorsum contacts obstacle, cutaneous mechanoreceptors send afferent signals to spinal cord elicit coordinated reflex responses in ensure dynamic balance and forward progression. To determine how locomotor pattern all changes response a sensory perturbation evoked by activating afferents from one hindlimb, we electrically stimulated superficial peroneal (SP) nerve with relatively long train at...
Abstract In quadrupeds, such as cats, cutaneous afferents from the forepaw dorsum signal external perturbations and send inputs to spinal circuits co‐ordinate activity in muscles of all four limbs. How these reflex pathways forelimb are reorganized after an incomplete cord injury is not clear. Using a staggered thoracic lateral hemisections paradigm, we investigated changes intralimb interlimb by electrically stimulating left right superficial radial nerves seven adult cats recording...
Introduction This study aimed to determine the intra- and inter-session reliability of neuromuscular assessment plantar flexor (PF) muscles at three knee angles. Methods Twelve young adults were tested for angles (90°, 30° 0°) time points separated by 1 hour (intra-session) 7 days (inter-session). Electrical (H reflex, M wave) mechanical (evoked maximal voluntary torque, activation level) parameters measured on PF muscles. Intraclass correlation coefficients (ICC) variation calculated...
Mechanically stimulating the dorsal lumbar region inhibits locomotion and reduces weight support during standing in rabbits cats. However, how this inhibitory effect from skin is mediated poorly understood. Here we evaluated of mechanically (vibration or pinch) on short-latency (8- to 13-ms onset) cutaneous reflex responses, evoked by electrically superficial peroneal distal tibial nerves, seven adult cats with a low thoracic spinal transection (spinal cats). Cutaneous reflexes were before,...
Locomotion after complete spinal cord injury (spinal transection) in animal models is usually evaluated a hindlimb-only condition with the forelimbs suspended or placed on stationary platform and compared quadrupedal locomotion intact state. However, because of nature movement these animals, play an important role modulating hindlimb pattern. This raises question: whether changes pattern transection are due to state system (intact versus spinal) hindlimb-only. We collected kinematic...
Coordinating the four limbs is critical for terrestrial mammalian locomotion. Thoracic spinal transection abolishes neural communication between brain and networks controlling hindlimb/leg movements. Several studies have shown that animal models of (spinalization), such as mice, rats, cats, dogs recover hindlimb locomotion with forelimbs stationary or suspended. We know less on ability to generate quadrupedal after transection, however. collected kinematic electromyography data in adult cats...
Sickle cell disease (SCD) patients display skeletal muscle hypotrophy, altered oxidative capacity, exercise intolerance and poor quality of life. We previously demonstrated that moderate-intensity endurance training is beneficial for improving function life patients. The present study evaluated the effects this program on structural metabolic properties. Of 40 randomized SCD patients, complete data sets were obtained from 33. group (n = 15) followed a personalized program, while non-training...
Summary This study aimed to compare the effect of different types pressure applied stimulation electrode on assessing efficiency Ia‐α‐motoneuron transmission soleus muscle and associated discomfort using electrical nerve stimulation. Twelve healthy young adults participated in three experimental sessions (one for each knee angle). The amplitudes maximal Hoffmann reflex ( H max ) motor potential M were recorded from at 0°, 30° 90° angles (0° full extension) through applications electrode: no...
It is well known that mechanically stimulating the perineal region potently facilitates hindlimb locomotion and weight support in mammals with a spinal transection (spinal mammals). However, how stimulation mediates this excitatory effect poorly understood. We evaluated of (vibration or pinch) on ipsilateral (9-14 ms onset) contralateral (14-18 short-latency cutaneous reflex responses evoked by electrically superficial peroneal distal tibial nerve seven adult cats where movement was...
Spinal sensorimotor circuits interact with supraspinal and peripheral inputs to generate quadrupedal locomotion. Ascending descending spinal pathways ensure coordination between the fore-and hindlimbs. cord injury disrupts these pathways. To investigate control of interlimb hindlimb locomotor recovery, we performed two lateral thoracic hemisections placed on opposite sides (right T5-T6 left T10-T11) at an interval approximately months in eight adult cats. In three cats, then made a complete...
In quadrupeds, such as cats, cutaneous afferents from the forepaw dorsum signal external perturbations and send signals to spinal circuits coordinate activity in muscles of all four limbs. How these reflex pathways forelimb are reorganized after an incomplete cord injury is not clear. Using a staggered thoracic lateral hemisections paradigm, we investigated changes intralimb interlimb by electrically stimulating left right superficial radial nerves seven adult cats recording responses five...
Abstract Following incomplete spinal cord injury in animals, including humans, substantial locomotor recovery can occur. However, functional aspects of locomotion, such as negotiating an obstacle remains challenging. We collected kinematic and electromyography data ten adult cats before at weeks 1-2 7-8 after a lateral mid-thoracic hemisection while they negotiated obstacles three different heights. Intact always cleared without contact. At hemisection, the ipsilesional hindlimb contacted...
Constitutional thinness (CT) is a nonpathological state of underweight. The current study aimed to explore skeletal muscle energy storage in individuals with CT and further characterize phenotype at baseline response overfeeding. Thirty subjects (15 females, 15 males) 31 normal-weight control (16 participated the study. Histological enzymological analyses were performed on biopsy specimens before after In participants compared controls, we observed lower content intramuscular triglycerides...
Abstract Mammals walk in different directions, such as forward and backward. In human infants/adults decerebrate cats, one leg can the other backward simultaneously on a split‐belt treadmill, termed hybrid or bidirectional locomotion. The purpose of present study was to determine if spinal sensorimotor circuits generate locomotion so, how limbs remain coordinated. We tested 11 intact cats five following complete thoracic transection (spinal cats) at three treadmill speeds with hindlimbs...
Patients with sickle cell disease (SCD) display lower slope coefficients of the oxygen uptake (V_O2) vs. work rate (W) relationship (delineating an O2 uptake/demand mismatch) and a poor metabolic flexibility. Because endurance training (ET) increases microvascular network oxidative enzymes activity including one involved in lipid oxidation, ET might improve coefficient V_O2 W curve flexibility SCD patients. may also contribute to patient post-exercise cardiopulmonary recovery. Fifteen...