A5035869790- Obstructive Sleep Apnea Research
- Atrial Fibrillation Management and Outcomes
- Neuroscience of respiration and sleep
- Cardiac Arrhythmias and Treatments
- Heart Rate Variability and Autonomic Control
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular and Diving-Related Complications
- Cardiac electrophysiology and arrhythmias
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Blood Pressure and Hypertension Studies
- Cardiac pacing and defibrillation studies
- Sodium Intake and Health
- Ion Transport and Channel Regulation
- Cardiovascular Disease and Adiposity
- Respiratory and Cough-Related Research
- Heart rate and cardiovascular health
- High Altitude and Hypoxia
- Cardiac Ischemia and Reperfusion
- Nutritional Studies and Diet
- Cardiac Health and Mental Health
- Cardiac Arrest and Resuscitation
- Diet and metabolism studies
- Colorectal Cancer Surgical Treatments
- Venous Thromboembolism Diagnosis and Management
- Barrier Structure and Function Studies
Praxis für Hämatologie und Onkologie
2025
University Hospital Schleswig-Holstein
2025
University of Lübeck
2025
University of Copenhagen
2019-2024
Frederiksberg Hospital
2023
Bispebjerg Hospital
2023
Saarland University
2017-2020
Universitätsklinikum des Saarlandes
2013-2017
The University of Adelaide
2017
Fresenius (Germany)
2015
Abstract Aims Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly used to treat type 2 diabetes and obesity. Albeit cardiovascular outcomes generally improve, treatment with GLP-1 RAs is associated increased heart rate, the mechanism of which unclear. Methods results We employed a large animal model, female landrace pig, multiple in vivo ex approaches including pharmacological challenges, electrophysiology, high-resolution mass spectrometry explore how elicits an increase...
Hypertension and metabolic syndrome (MetS) are associated with increased sympathetic activation possibly contributing to the progression of renal damage cardiac remodeling. Renal denervation (RDN) decreases efferent afferent nerve activity. Obese spontaneously hypertensive rats (SHRs-ob) were subjected RDN at age 34 weeks (SHRs-ob + RDN) compared sham-operated SHRs-ob their normotensive lean controls (Ctrs). Blood pressure was measured by telemetry. Kidney heart function determined magnetic...
Background Besides hypertension, obesity and the metabolic syndrome have recently emerged as risk factors for atrial fibrillation. This study sought to delineate development of an arrhythmogenic substrate fibrillation in hypertension with without concomitant syndrome. Methods Results We compared obese spontaneously hypertensive rats ( SHR ‐obese, n=7–10) lean controls ‐lean, normotensive (n=7–10). Left emptying function (MRI) electrophysiological parameters were characterized before hearts...
BackgroundHigh night-to-night variability in obstructive sleep apnea (OSA) is associated with atrial fibrillation (AF). Obstructive apneas are characterized by intermittent deoxygenation-reoxygenation and intrathoracic pressure swings during ineffective inspiration against occluded upper airways.ObjectiveWe elucidated the effect of repeated exposure to transient OSA conditions simulated negative airway (INAP) on development an AF substrate.MethodsINAP (48 events/4 h; apnea-hypopnea index 12...
Obstructive sleep apnea (OSA) is associated with hypertension and the progression of chronic kidney disease (CKD). Renal sympathetic innervation contributes to either condition. We investigated effect renal denervation (RDN) on blood pressure (BP), perfusion, neurohumoral responses during after repetitive obstructive apneas in a pig model for OSA. BP, femoral artery, artery flow were measured 29 spontaneously breathing urethane-chloralose–anesthetized pigs. The RDN (n = 14) irbesartan 3) was...
In patients with chronic kidney disease (CKD), atrial fibrillation (AF) is highly prevalent and represents a major risk factor for stroke death. CKD associated proarrhythmic remodeling activation of the sympathetic nervous system. Whether reduction nerve activity by renal denervation (RDN) inhibits AF vulnerability in unknown.Left (LA) fibrosis was analyzed samples from concomitant (estimated glomerular filtration rate [eGFR], <60 mL/min per 1.73 m2) using picrosirius red compared without...
Sleep disordered breathing ( SDB ) is highly prevalent in patients with high blood pressure BP ). Severity of can be evaluated by the number apneas and hypopneas per hour AHI or measures hypoxia. The objective this study was to assess association between different . In 134 consecutive patients, polygraphy performed determine Pulse oximetry used hypoxemic burden (time below 90% oxygen saturation [T90] hypoxia load [ HL ], representing integrated area above curve desaturation). did not...
Increased sodium absorption in the gut is one mechanism contributing to hypertensive blood pressure values. The sodium-proton-exchanger subtype 3 (NHE3) an important mediator of intestinal absorption. compound SAR a new specific NHE3 inhibitor with extremely low oral absorbability leading decreased and substantial systolic reduction. effects inhibition on cardiac renal end-organ damage are unknown. (1 mg·kg−1·d−1 chow) left ventricular (LV) remodeling processes were studied by magnetic...
In the heart, serine carboxypeptidase cathepsin A (CatA) is distributed between lysosomes and extracellular matrix (ECM). CatA-mediated degradation of peptides may contribute to ECM remodeling left ventricular (LV) dysfunction. Here, we aimed evaluate effects CatA overexpression on LV remodeling. proteomic analysis secretome adult mouse cardiac fibroblasts upon digestion by identified antioxidant enzyme superoxide dismutase (EC-SOD) as a novel substrate CatA, which decreased EC-SOD abundance...
Obstructive sleep apnea (OSA) creates a complex substrate for atrial fibrillation (AF), which is refractory to many clinically available pharmacological interventions. We investigated antiarrhythmogenic properties and ventricular electrophysiological safety of small-conductance Ca2+ -activated K+ (SK)-channel inhibition in porcine model obstructive respiratory events.In spontaneously breathing pigs, events were simulated by intermittent negative upper airway pressure (INAP) applied via...
To propose a standardized workflow for 3D-electroanatomical mapping guided pulmonary vein isolation in pigs.Danish female landrace pigs were anaesthetized. Ultrasound-guided puncture of both femoral veins was performed and arterial access blood pressure measurement established. Fluoroscopy- intracardiac ultrasound-guided passage the patent foramen ovale or transseptal performed. Then, left atrium conducted using high-density catheter. After all veins, an irrigated radiofrequency ablation...
Increased sodium uptake has been shown to contribute hypertension and cardiac end-organ damage. The sodium-proton-exchanger subtype 3 (NHE3) is an important mediator of intestinal absorption. Whether a reduction in absorption can prevent the development atrial arrhythmogenic substrate unknown. Eight-week-old obese spontaneously hypertensive rats (SHR-ob) were treated for six weeks with gut-specific NHE3-inhibitor SAR...
Abstract Aims Pulmonary vein isolation (PVI) is the corner stone of modern rhythm control strategies in patients with atrial fibrillation (AF). Sleep-disordered breathing (SDB) prevalent more than 50% undergoing AF ablation, and studies have indicated a greater recurrence rate after PVI SDB. Herein, we study effect catheter-based on pig model for Methods results In 11 sedated spontaneously pigs, obstructive apnoeas were simulated by 75 s intermittent negative upper airway pressure (INAP)...