A5073497325- RNA modifications and cancer
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- Health, Environment, Cognitive Aging
- Renal and related cancers
- Endoplasmic Reticulum Stress and Disease
- Pediatric Urology and Nephrology Studies
- Glycosylation and Glycoproteins Research
- Hybrid Renewable Energy Systems
- Circadian rhythm and melatonin
- Neuroscience of respiration and sleep
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Cancer, Stress, Anesthesia, and Immune Response
- Toxin Mechanisms and Immunotoxins
Charles University
2019-2025
Abstract In patients with testicular germ cell tumours (TGCT), sperm cryopreservation prior to anti-cancer treatment represents the main fertility preservation approach. However, it is associated low recovery rate after thawing. Since a high-energy demanding cell, which supplied by glycolysis and oxidative phosphorylation (OXPHOS), mitochondrial dysfunctionality can directly result in anomalies. this study, we investigated bioenergetic pattern of cryopreserved TGCT comparison normozoospermic...
The pathogenesis of Alzheimer's disease (AD), the most prevalent form dementia, remains unclear. Over past few years, evidence has accumulated indicating that perturbed cerebral bioenergetics and neuroinflammation may compromise cognitive functions precedes onset AD impaired function glial cells can likely contribute to development disease. Recently, N6-methyladenosine (m6A) modification RNA been implicated in regulation different processes brain play a potential role neurodegeneration. In...
N6-methyladenosine (m
In testicular germ cell tumour (TGCT) patients, sperm cryopreservation prior to anti-cancer treatment represents the main fertility preservation approach. However, it is associated with low recovery rate after thawing. Since a high-energy demanding cell, which supplied by glycolysis and oxidative phosphorylation (OXPHOS), mitochondrial dysfunctionality can directly result in anomalies. this study, we investigated bioenergetic pattern of cryopreserved TGCT patients comparison normozoospermic...