A5023378285- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Fatty Acid Research and Health
- Lipid metabolism and biosynthesis
- Circadian rhythm and melatonin
- Planarian Biology and Electrostimulation
- interferon and immune responses
- Muscle metabolism and nutrition
- Sleep and Wakefulness Research
- Genomics and Rare Diseases
- Neuroendocrine regulation and behavior
- Amyotrophic Lateral Sclerosis Research
- Cancer, Hypoxia, and Metabolism
- Biochemical Analysis and Sensing Techniques
- RNA regulation and disease
- Receptor Mechanisms and Signaling
- Central Venous Catheters and Hemodialysis
- Genetics, Aging, and Longevity in Model Organisms
- Pancreatic function and diabetes
- Photoreceptor and optogenetics research
- Neuroscience of respiration and sleep
- Nicotinic Acetylcholine Receptors Study
- Molecular Communication and Nanonetworks
- Adenosine and Purinergic Signaling
- Cardiac Ischemia and Reperfusion
Albert Einstein College of Medicine
2019-2025
Yeshiva University
2021
SUNY Upstate Medical University
2015-2016
Janelia Research Campus
2012
Helix (United States)
2012
Howard Hughes Medical Institute
2012
Nagoya Institute of Technology
2009
Drexel University
1987
It is well recognized that feeding behavior in mammals orchestrated by neurons within the medial basal hypothalamus. However, it remains unclear whether food intake also under control of glial cells. Here, we combine chemical genetics, cell-type-specific electrophysiology, pharmacology, and assays to show stimulation astrocytes hypothalamus reduces both basal- ghrelin-evoked intake. This occurs a mechanism adenosine-mediated inactivation orexigenic agouti-related peptide (AGRP) hypothalamic...
Small molecules are important tools to measure and modulate intracellular signaling pathways. A longstanding limitation for using chemical compounds in complex tissues has been the inability target bioactive small a specific cell class. Here, we describe generalizable esterase–ester pair capable of targeted delivery living cells tissue with cellular specificity. We used fluorogenic rapidly identify ester masking motif that is stable endogenous esterases, but efficiently removed by an...
Abstract It is well recognized that ventromedial hypothalamus (VMH) serves as a satiety center in the brain. However, feeding circuit for VMH regulation of food intake remains to be defined. Here, we combine fiber photometry, chemo/optogenetics, virus-assisted retrograde tracing, ChR2-assisted mapping and behavioral assays show selective activation neurons expressing steroidogenic factor 1 (SF1) rapidly inhibits intake, SF1 project dense fibers paraventricular thalamus (PVT),...
It has been well documented that cold is an enhancer of lipid metabolism in peripheral tissues, yet its effect on central nervous system dynamics underexplored. recognized acclimations enhance adipocyte functions, including white adipose tissue lipolysis and beiging, brown thermogenesis mammals. However, it remains unclear whether how the brain also under control ambient temperature. Here, we show exposure predominantly increases expressions genes proteins within paraventricular nucleus...
Traumatic brain injury (TBI) is a common neurotrauma leading to dysfunction and death. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) hold promise in the treatment of TBI. However, their efficacy modest due low survival differentiation under harsh microenvironment injured brain. MG53, member TRIM family protein, plays vital role cell tissue damage repair. The present study aims test whether MG53 preserves hUC-MSCs against oxidative stress enhances TBI treatment.In this study,...
Emerging evidence shows that hypothalamic astrocytes react to and counteract energy surfeit produced by high-fat diet (HFD) feeding. However, the functional role of in control states underlying molecular mechanism(s) during physiological conditions remain largely underexplored. In present study, taking advantage spatiotemporally precise optogenetic approaches, real-time measurements extracellular adenosine, behavioral assays, we find stimulation localized medial basal hypothalamus (MBH)...
ABSTRACT Emerging evidence indicates that astrocytes modulate energy metabolism and homeostasis. However, one important but poorly understood element is the necessity of in control body weight. Here, we apply viral vector‐assisted brain‐region selective loss to define physiological roles played by arcuate nucleus hypothalamus (ARH) elucidate involved mechanism. We find astrocyte potently augments weight adult mice fed chow or high‐fat diet. Mechanistically, reduces adipose tissue...
Abstract Recent studies indicate that activation of hypothalamic Agouti-related protein (Agrp) neurons can increase forage-related/repetitive behavior and decrease anxiety levels. However, the impact physiological hunger states food deprivation on anxiety-related behaviors have not been clarified. In present study, we evaluated changes in levels induced by deprivation, identified neuron population involved. Ad libitum fed fasted mice were tested open field elevated plus-maze behavioral...
Abstract Background It is established that pulmonary disorders are comorbid with metabolic such as obesity. Previous studies show the stimulator of interferon genes (STING) signaling plays crucial roles in obesity-induced chronic inflammation via TANK-binding kinase 1 (TBK1) pathways. However, it remains unknown whether and how STING implicated inflammatory processes lung Methods Human tissues were obtained from obese patients ( n = 3) controls 3). Mice fed high-fat diet or regular control...
Abstract The neuropeptide oxytocin (OXT) is well recognized for eliciting anxiolytic effects and promoting social reward. However, emerging evidence shows that OXT increases aversive events. These seemingly inconsistent results may be attributable to the broad receptor (OXTr) expression in central nervous system. This study selectively activated septal neurons expressing OXTr using chemogenetics. We found chemogenetic activation of induced anxiety- but not depressive-like behavior. In...
Abstract The role of non-neuronal glial cells in the regulation adipose sympathetic nerve activity and adipocyte functions such as white tissue lipid lipolysis is poorly understood. Here, we combine chemo/optogenetic manipulations medio-basal hypothalamic astrocytes, real-time fiber photometry monitoring norepinephrine (NE) contents activities, electrophysiological recordings local inputs to inguinal (iWAT), lipolytic assays define functional roles astrocytes iWAT outflow lipolysis. Our...
Glucose homeostasis can be improved after bariatric surgery that alters bile flow and stimulate gut hormone secretion, in particular FGF15/19. FGFR1 expression AGRP expressing cells is required for acids's ability to improve glucose control. We show the mouse Agrp gene has 3 promoter/enhancer regions direct transcription of each their own transcripts. One these promoters/enhancers, B, regulated by acids. generated an B knock-in FLP/knockout allele. are found endocrine pars tuberalis (PT)...
Abstract Ample evidence indicates that obesity causes dysfunctions in the lung. Previous studies also show cholinergic anti-inflammatory pathways play crucial roles obesity-induced chronic inflammation via α7 nicotinic acetylcholine receptor (α7nAChR) signaling. However, it remains unclear whether and how affects expressions of α7nAChR myeloid cells To address this question, we treated regular chow diet-fed mice or high-fat diet induced obese with lipopolysaccharide (LPS) vehicle...
Abstract It has been well documented that cold is an enhancer of lipid metabolism in peripheral tissues, yet its effect on central nervous system dynamics underexplored. recognized acclimations enhance adipocyte functions, including white adipose tissue (WAT) lipolysis and beiging, brown (BAT) thermogenesis mammals. However, it remains unclear whether how the brain also under control acclimations. Here, we show exposure predominantly increases expressions genes proteins within...
Previous studies have been focused on lipid metabolism in peripheral tissues such as adipose tissues, while little or nothing is known about that the brain. It well recognized cold acclimations enhance adipocyte functions, including white tissue (WAT) lipolysis and beiging, brown (BAT) thermogenesis mammals. However, it remains unclear whether how genes responsible for brain are also under control of acclimations. Here, we show exposure predominantly increases expressions encoding...
It has been well documented that cold is an enhancer of lipid metabolism in peripheral tissues, yet its effect on central nervous system dynamics underexplored. recognized acclimations enhance adipocyte functions, including white adipose tissue lipolysis and beiging, brown thermogenesis mammals. However, it remains unclear whether how the brain also under control ambient temperature. Here, we show exposure predominantly increases expressions genes proteins within paraventricular nucleus...
It has been well documented that cold is an enhancer of lipid metabolism in peripheral tissues, yet its effect on central nervous system dynamics underexplored. recognized acclimations enhance adipocyte functions, including white adipose tissue (WAT) lipolysis and beiging, brown (BAT) thermogenesis mammals. However, it remains unclear whether how the brain also under control acclimations. Here, we show exposure predominantly increases expressions genes proteins within paraventricular nucleus...