A5030395669- Circadian rhythm and melatonin
- Spaceflight effects on biology
- Genetics, Aging, and Longevity in Model Organisms
- Cellular Mechanics and Interactions
- Neuroscience and Neural Engineering
- Advanced Fluorescence Microscopy Techniques
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Force Microscopy Techniques and Applications
- Pancreatic function and diabetes
Albert Einstein College of Medicine
2023-2024
Glucose homeostasis can be improved after bariatric surgery that alters bile flow and stimulate gut hormone secretion, in particular FGF15/19. FGFR1 expression AGRP expressing cells is required for acids's ability to improve glucose control. We show the mouse Agrp gene has 3 promoter/enhancer regions direct transcription of each their own transcripts. One these promoters/enhancers, B, regulated by acids. generated an B knock-in FLP/knockout allele. are found endocrine pars tuberalis (PT)...
Expansion Microscopy is a super-resolution technique in which physically enlarging samples an isotropic manner increases inter-molecular distances such that nano-scale structures can be resolved using light microscopy. This particularly useful neuroscience as many important are smaller than the diffraction limit. Since its invention 2015, variety of protocols have been generated and applied to advance knowledge prominent organisms neuroscience, including zebrafish, mice, Drosophila, C....
Asymmetric brain function is common across the animal kingdom and involved in language processing, likely learning memory. What regulates asymmetric remains elusive. Here, we show that nematode Caenorhabditis elegans restructures an salt sensing neural circuit during associative learning. Worms memorize prefer concentration at which they were raised presence of food through a left-biased network architecture. When conditioned elevated concentrations, animals change to right-biased network,...