A5107339873- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Neonatal Health and Biochemistry
- Erythrocyte Function and Pathophysiology
- Infrared Thermography in Medicine
- Erythropoietin and Anemia Treatment
- Thermoregulation and physiological responses
- Body Composition Measurement Techniques
- Blood properties and coagulation
- Exercise and Physiological Responses
Université des Antilles
2020-2021
Inflammation and oxidative stress play a key role in the pathophysiology of sickle cell disease (SCD). However, potential influence different genotypes, or hydroxyurea (HU) treatment, on these factors remains poorly documented. The present study compared several plasma markers inflammation stress, as well microvascular function, between patients with SC (HbSC, n = 19) anemia (HbSS) under treatment (n 16), not 13). Hemorheological parameters levels inflammatory (IL-6, IL-8, IFN-γ, MCP-1,...
Sickle cell anemia (SCA) affects millions of people worldwide. This genetic disease is caused by a single mutation in the β-globin gene, leading to production abnormal hemoglobin S (HbS), which polymerizes under deoxygenation. The resulting fragility and loss deformability red blood cells (RBCs) lead chronic vaso-occlusive complications. However, this basic pathophysiology description does not fully explain wide heterogeneity clinical expression disease. While role played vascular system...
Summary Hypoxia‐mediated red blood cell (RBC) sickling is central to the pathophysiology of sickle disease (SCD). The signalling nucleoside adenosine thought play a significant role in this process. This study investigated expression erythrocyte type 1 equilibrative transporter (ENT1), key regulator plasma adenosine, adult patients with SCD and carriers trait (SCT). Relative quantitative analysis ENT1 was carried out by Western blot flow cytometry. Patients steady state conditions, either SS...
Background and objective Warm exposure places high demands on thermoregulation mechanisms, which depend the effectiveness of microvascular function. The associations between microcirculation metabolism in warm environments have received little attention. purpose this study was to explore skin blood flow (SkBF) response food intake a environment compared control.Methods Thirty-two healthy, acclimated-to-warm-environment physically active participants were recruited (20 females 12 males). They...
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main source(s): European Commission, Region Guadeloupe Background. Sickle cell trait (SCT) is an inherited red blood condition without medical consequence in most cases. However, its strong association with increased risk exercise-induced sudden death (independent pre-existing disease) or exertional collapse has been demonstrated athletes, military recruits and firefighters. The mechanisms potentially...