A5015644536- Neural dynamics and brain function
- stochastic dynamics and bifurcation
- Nonlinear Dynamics and Pattern Formation
- Neuroscience and Neural Engineering
- Advanced Memory and Neural Computing
- Mathematical Biology Tumor Growth
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Gene Regulatory Network Analysis
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Microtubule and mitosis dynamics
- Glioma Diagnosis and Treatment
- Fractional Differential Equations Solutions
- Hepatitis C virus research
- Immune cells in cancer
- Mathematical and Theoretical Epidemiology and Ecology Models
- Syphilis Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune Cell Function and Interaction
- Herpesvirus Infections and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Soil Management and Crop Yield
SUNY Downstate Health Sciences University
2022-2024
Universidade Estadual de Ponta Grossa
2013-2024
State University of New York
2021-2024
Universidade Federal do ABC
2018-2024
Universidade de São Paulo
2017-2018
Hospital de Egas Moniz
2006-2017
Instituto de Gastroenterologia de Goiânia
2014
Brain organoids with Neanderthal genes The genomes of Neanderthals and modern humans are overall very similar. To understand the impact genetic variants that specific to humans, Trujillo et al. performed a genome-wide analysis identify 61 coding in protein-coding genes. Identifying gene encoding RNA-binding protein NOVA1 as top candidate for functional analyses, they introduced archaic variant into human pluripotent stem cells generated brain organoids. These showed alterations expression...
Computational neuroscience is uniquely positioned to address challenging questions about the brain. Modeling distinct levels of organization in a computer offers scientists ability access variables that are otherwise hidden living systems and experiment with scenarios may be non-feasible wet lab. Since seminal work Hodgkin Huxley, understanding how neurons process information communicate has been explored by various across different domains. With recent developments artificial intelligence,...
Excessively high, neural synchronization has been associated with epileptic seizures, one of the most common brain diseases worldwide. A better understanding mechanisms can thus help control or even treat epilepsy. In this paper, we study in a random network where nodes are neurons excitatory and inhibitory synapses, activity for each node is provided by adaptive exponential integrate-and-fire model. framework, verify that decrease influence inhibition generate originating from pattern...
The primary somatosensory cortex (S1) of mammals is critically important in the perception touch and related sensorimotor behaviors. In 2015, Blue Brain Project (BBP) developed a groundbreaking rat S1 microcircuit simulation with over 31,000 neurons 207 morpho-electrical neuron types, 37 million synapses, incorporating anatomical physiological information from wide range experimental studies. We have implemented this highly detailed complex model NetPyNE, using data available Neocortical...
Abstract Important functions of the prefrontal cortex (PFC) are established during early life, when neurons exhibit enhanced synaptic plasticity and synaptogenesis. This developmental stage drives organization cortical connectivity, responsible for establishing behavioral patterns. Serotonin (5-HT) emerges among most significant factors that modulate brain activity postnatal development. In PFC, activated 5-HT receptors modify neuronal excitability interact with intracellular signaling...
The patient was diagnosed with HIV-related encephalopathy and disseminated Mycobacterium tuberculosis infection.
In the soil science, a direct method that allows study of pore distribution is bi-dimensional (2D) digital image analysis. Such technique provides quantitative results shape, number and size. The use specific softwares for treatment processing images fast efficient to quantify porous system. However, due high cost commercial softwares, public ones can be an interesting alternative structure objective this work was evaluate quality data provided by Image J software (public domain) used...
Chimera states are spatiotemporal patterns in which coherence and incoherence coexist. We observe the coexistence of synchronous (coherent) desynchronous (incoherent) domains a neuronal network. The network is composed coupled adaptive exponential integrate-and-fire neurons that connected by means chemical synapses. In our network, chimera exhibit spatial structures both with spikes bursts activities. Furthermore, those desynchronised not only have either spike or burst activity, but we show...
We consider a network topology according to the cortico-cortical connection of human brain, where each cortical area is composed random adaptive exponential integrate-and-fire neurons.Depending on parameters, this neuron model can exhibit spike or burst patterns. As diagnostic tool identify and patterns we utilise coefficient variation neuronal inter-spike interval.In our network, verify existence synchronisation in different areas.Our simulations show that arrangement, i.e. its rich-club...
We have studied the effects of perturbations on cat's cerebral cortex. According to literature, this cortex structure can be described by a clustered network. This way, we construct network with same number areas as in cat matrix, where each area is sub-network small-world property. focus suppression neuronal phase synchronisation considering different kinds perturbations. Among various controlling interventions, choose three methods: delayed feedback control, external time-periodic driving,...
The description of neuronal activity has been great importance in neuroscience. In this field, mathematical models are useful to describe the electrophysical behavior neurons. One successful model used for purpose is Adaptive Exponential Integrate-and-Fire (Adex), which composed two ordinary differential equations. Usually, considered standard formulation, i.e., with integer order derivatives. work, we propose and study fractal extension Adex model, simple terms corresponds replacing...
The Treponema pallidum particle agglutination technique (TP.PA) was evaluated, in comparison with the Venereal Disease Research Laboratory (VDRL) test, microhemagglutination assay for antibodies (MHA-TP), and fluorescent treponemal antibody-ABS (FTA-Abs) test diagnosis of neurosyphilis.We have studied 198 cerebrospinal fluid (CSF) samples from patients syphilis, including neurosyphilis, treated other neurological manifestations than neurosyphilis. All tests were nonreactive these last group...
In the brain, excitation-inhibition balance prevents abnormal synchronous behaviour. However, known synaptic conductance intensity can be insufficient to account for undesired synchronisation. Due this fact, we consider time delay in excitatory and inhibitory conductances study its effect on neuronal work, build a network composed of adaptive integrate-and-fire neurons coupled by means delayed conductances. We observe that conductivities alter both state collective behaviour (synchronous or...