A5044776329- Primate Behavior and Ecology
- Memory and Neural Mechanisms
- Williams Syndrome Research
- Neural dynamics and brain function
- Autism Spectrum Disorder Research
- Hemispheric Asymmetry in Neuroscience
- Congenital heart defects research
- Child and Animal Learning Development
- Morphological variations and asymmetry
- Language and cultural evolution
- Pleistocene-Era Hominins and Archaeology
- Genetics and Neurodevelopmental Disorders
- Action Observation and Synchronization
- Functional Brain Connectivity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Animal Vocal Communication and Behavior
- Nuclear Receptors and Signaling
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Neuroendocrine regulation and behavior
- Alzheimer's disease research and treatments
- Cell Image Analysis Techniques
- Attention Deficit Hyperactivity Disorder
- Neurobiology of Language and Bilingualism
University of California, San Diego
2016-2025
University of California, San Francisco
2019
University of Chicago
2019
Duke University
2019
Evidence Based Research (United States)
2019
Central Michigan University
2019
California Institute of Technology
2011
University of California San Diego Medical Center
2007
Neurological Surgery
2007
Museum of Indian Arts and Culture
2006
Area 10 is one of the cortical areas frontal lobe involved in higher cognitive functions such as undertaking initiatives and planning future actions. It known to form pole macaque human brain, but its presence organization great lesser apes remain unclear. here documented that area also forms chimpanzee, bonobo, orangutan, gibbon brains. Imaging techniques stereological tools are used characterize this across species provide preliminary estimates absolute relative size. has similar...
The von Economo neurons (VENs) are large bipolar located in frontoinsular (FI) and anterior cingulate cortex great apes humans, but not other primates. We performed stereological counts of the VENs FI LA (limbic anterior, a component cortex) humans. more numerous humans than apes, although one gorilla approached lower end human range. also examined ontological development first appear small numbers 36th week post-conception, rare at birth, increase number during 8 months after birth. There...
Brain organoids with Neanderthal genes The genomes of Neanderthals and modern humans are overall very similar. To understand the impact genetic variants that specific to humans, Trujillo et al. performed a genome-wide analysis identify 61 coding in protein-coding genes. Identifying gene encoding RNA-binding protein NOVA1 as top candidate for functional analyses, they introduced archaic variant into human pluripotent stem cells generated brain organoids. These showed alterations expression...
Few morphological differences have been identified so far that distinguish the human brain from brains of our closest relatives, apes. Comparative analyses spatial organization cortical neurons, including minicolumns, can aid understanding functionally relevant aspects microcircuitry. We measured horizontal spacing distance and gray-level ratio in layer III 4 regions ape cortex all 6 living hominoid species: frontal pole (Brodmann area [BA] 10), primary motor (BA 4), somatosensory 3), visual...
The primate cerebral cortex is characterized by regional variation in the structure of pyramidal neurons, with more complex dendritic arbors and greater spine density observed prefrontal compared sensory motor cortices. Although there are several investigations humans other primates, virtually nothing known about morphology neurons great apes, humans' closest living relatives. current study uses rapid Golgi stain to quantify layer III 4 areas chimpanzee cortex: Primary somatosensory (area...
Comparative analyses of neuronal phenotypes in closely related species can shed light on changes occurring during evolution. The study post-mortem brains nonhuman primates (NHPs) has been limited and often does not recapitulate important species-specific developmental hallmarks. We utilize induced pluripotent stem cell (iPSC) technology to investigate the development cortical pyramidal neurons following migration maturation cells grafted developing mouse cortex. Our results show differential...
Cell minicolumns were shown to be narrower in frontal regions brains of autistic patients compared with controls. This was not found primary visual cortex. Within the cortex, dorsal and orbital displayed greatest differences while mesial region showed least change. We also that brain a 3‐year‐old child indistinguishable from those adult two three regions, contrast control brains. may have been due small size columns rather than an accelerated development. The presence supports theory there...
Abstract Broca's area was identified in the inferior frontal gyrus of chimpanzee, bonobo, gorilla, and orangutan brains through direct cytoarchitectonic comparison with human brains. Across species, comprises Brodmann's areas 44 45. We found that these exhibited similar characteristics all species examined. analyzed minicolumnar organization cells layer III 11 9 great ape specimens. A semiautomated method used to analyze digitized images histological sections stained for Nissl substance....
Increasingly, functional and evolutionary research has highlighted the important contribution emotion processing makes to complex human social cognition. As such, it may be asked whether neural structures involved in processing, commonly referred as limbic structures, have been impacted brain evolution. To address this question, we performed an extensive analysis of multiple using modern phylogenetic tools. For analysis, combined new volumetric data for hominoid (human ape) amygdala 4...
The limbic frontal cortex forms part of the neural substrate responsible for emotional reactions to social stimuli. Area 13 is one cortical areas long known be posterior orbitofrontal in several monkey species, such as macaque. Its presence nevertheless human brain has been unclear, and lobe great lesser apes remains largely unknown. In this study area was identified human, chimpanzee, bonobo, gorilla, orangutan, gibbon brains, maps were generated on basis its cytoarchitecture. Imaging...
Wisdom has been discussed for centuries in religious and philosophical texts. It is often viewed as a fuzzy psychological construct analogous to consciousness, stress, resilience. This essay provides an understanding of wisdom scientific construct, based on empirical research starting the 1970s. The focus practical rather than theoretical wisdom. While there are different conceptualizations wisdom, it best defined complex human characteristic or trait with specific components: social...