A5090360409- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- CRISPR and Genetic Engineering
- Photoreceptor and optogenetics research
- Signaling Pathways in Disease
- Cellular Mechanics and Interactions
- RNA Research and Splicing
- Williams Syndrome Research
- Pluripotent Stem Cells Research
- Developmental Biology and Gene Regulation
- Neuroscience and Neural Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
- Congenital heart defects research
- Cell Adhesion Molecules Research
University of California, Riverside
2017-2023
Salk Institute for Biological Studies
2016
Proper neural circuit organization requires individual neurons to project their targets with high specificity. While several guidance molecules have been shown mediate axonal fasciculation and pathfinding, less is understood about how intracellularly interpret integrate these cues. Here we provide genetic evidence that the Crk-Associated Substrate (Cas) family of intracellular adaptor proteins required for proper two cortical white matter tracts: Anterior Commissure (AC) thalamocortical...
Abstract During mammalian cerebellar development, postnatal granule cell progenitors proliferate in the outer part of External Granule Layer (EGL). Postmitotic migrate tangentially inner EGL before switching to radially inward, past Purkinje layer, achieve their final position mature Cell (GCL). Here, we show that RacGAP β-chimaerin is expressed by a small population late-born, premigratory cells. deficiency causes subset cells become arrested EGL, where they differentiate and form ectopic...
The mature mammalian cortex is composed of 6 architecturally and functionally distinct layers. Two key steps in the assembly this layered structure are initial establishment glial scaffold subsequent migration postmitotic neurons to their final position. These processes involve precise timely regulation adhesion detachment neural cells from substrates. Although much known about roles adhesive substrates during neuronal formation scaffold, less understood how these signals interpreted...
ABSTRACT The advent of modern single-cell biology has revealed the striking molecular diversity cell populations once thought to be more homogeneous. This newly appreciated complexity made intersectional genetic approaches essential understanding and probing cellular heterogeneity at functional level. Here, we build on previous knowledge develop a simple adeno-associated virus (AAV)-based approach define specific subpopulations cells by Boolean exclusion logic (AND NOT). expression (ExBoX)...
Abstract The mature mammalian cortex is composed of six architecturally and functionally distinct layers. Two key steps in the assembly this layered structure are initial establishment glial scaffold subsequent migration post-mitotic neurons to their final position. These processes involve precise timely regulation adhesion detachment neural cells from substrates. Although much known about roles adhesive substrates during neuronal formation scaffold, less understood how these signals...
Abstract During mammalian cerebellar development, postnatal granule cell progenitors proliferate in the outer part of External Granule Layer (EGL). Postmitotic migrate tangentially inner EGL before switching to radially inward, past Purkinje layer, achieve their final position mature Cell (GCL). Here, we show that RacGAP β-chimaerin is expressed by a small population late-born, premigratory cells. deficiency causes subset cells become arrested EGL, where they differentiate and form ectopic...
Abstract The advent of modern single-cell biology has revealed the striking molecular diversity cell populations once thought to be more homogeneous. This newly appreciated complexity made intersectional genetic approaches essential understanding and probing cellular heterogeneity at functional level. Here we build on previous knowledge develop a simple AAV-based approach define specific subpopulations cells by Boolean exclusion logic (AND NOT). Expression Exclusion (ExBoX) system encodes...