A5101414156- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Glycosylation and Glycoproteins Research
- Supramolecular Chemistry and Complexes
- Metal-Organic Frameworks: Synthesis and Applications
- Carbohydrate Chemistry and Synthesis
- Synthesis and Properties of Aromatic Compounds
- Supramolecular Self-Assembly in Materials
- Catalysis and Oxidation Reactions
- Proteoglycans and glycosaminoglycans research
- Mass Spectrometry Techniques and Applications
- Magnetism in coordination complexes
- Advanced NMR Techniques and Applications
- Luminescence and Fluorescent Materials
- Analytical Chemistry and Chromatography
- Catalytic Processes in Materials Science
- Ionic liquids properties and applications
- Covalent Organic Framework Applications
- Coral and Marine Ecosystems Studies
- Molecular Sensors and Ion Detection
- Aquaculture disease management and microbiota
- CO2 Reduction Techniques and Catalysts
- Advanced Proteomics Techniques and Applications
- Porphyrin and Phthalocyanine Chemistry
- Nonlinear Optical Materials Research
Nanjing University
2022-2025
Wanhua Chemical (China)
2025
Collaborative Innovation Center of Chemistry for Energy Materials
2020-2024
Xiamen University
2020-2024
Collaborative Innovation Center of Advanced Microstructures
2022-2024
Tan Kah Kee Innovation Laboratory
2024
Anhui University of Technology
2022-2023
Shanghai Institute of Organic Chemistry
2023
Texas Tech University
2016-2022
Dalian Institute of Chemical Physics
2022
Abstract The construction of nanotubes with well-defined structures, although synthetically challenging, offers the prospect studying novel chemical reactions and transportation within confined spaces, as well fabricating molecular devices nanoporous materials. Here we report a discrete nanotube, namely covalent organic pillar COP-1 , synthesized through [2 + 5] imine condensation reaction involving two penta-aldehyde macrocycles five phenylenediamine linkers. A pair enantiomeric nanotubes,...
Protein glycosylation is a common post-translational modification that has significant impacts on protein folding, lifespan, conformation, distribution and function.
Permethylation is a common derivatization method for MS-based glycomic analyses. enhances glycan ionization efficiency in positive MS analysis and improves structural stability. Recent biological studies have added to the growing body of knowledge suggest need complete glycans. However, reverse phase LC permethylated glycans usually results poor isomeric separation. To achieve separation glycans, porous graphitic carbon (PGC) column was used. PGC columns are well-known their capability...
Oligosaccharides in milk not only provide nutrition to the infants but also have significant immune biofunctions such as inhibition of pathogen binding host cell. The main component oligosaccharides is free oligosaccharides. Since proteins are highly glycosylated, N-glycans play an import role. In this study, we investigated permethylated and extracted from bovine, goat, human milks using LC-MS/MS. Quantitation profiles were reported. number observed samples (without isomeric consideration)...
Bifunctional catalysts with tandem processes have achieved great success in a wide range of important catalytic processes, however, this concept has hardly been applied the elimination volatile organic compounds. Herein, we designed bifunctional Zeolites-Silver catalyst that enormously boosted formaldehyde oxidation at low temperatures, and conversion increased by 50 times (100% versus 2%) 70 °C compared to monofunctional supported silver catalyst. This is enabled designing composed acidic...
While the majority of knots are made from metal-template approach, use entangled, constrained knotted loops to modulate coordination metal ions remains inadequately elucidated. Here, we report on chemistry a 140-atom-long cinquefoil strand comprising five tridentate and bidentate chelating vacancies. The loop is prepared through self-assembly asymmetric "3 + 2" dentate ligands with copper(II) that favor five-coordination geometry. formation pentameric helicate confirmed by X-ray...
Polyradicals, i.e., multispin organic molecules, are playing important roles in radical-based material applications for their spin–spin interaction. A dynamic covalently bonded molecule may endow materials with added function such as memory and switching. However, a species has yet to be reported. We here report the synthesis, characterization, crystal structure of triradical species. It is generated by self-assembly two molecules through Lewis acid coupled electron transfer. The crystalline...
The manipulation of chirality in molecular entities that rapidly interconvert between enantiomeric forms is challenging, particularly at the supramolecular level. Advances controlling such dynamic stereochemical systems offer opportunities to understand chiral symmetry breaking and homochirality. Herein, we report synthesis a face-rotating tetrahedron (FRT), an organic cage composed tridurylborane facial units undergo stereomutations trefoil propeller-like conformations. After resolution,...
Discovering novel families of molecular polyhedra through graph theory has attracted increasing interest. Nevertheless, the design principles based on remain elusive, especially for those containing five-node units. Herein, we construct a series chiral truncated face-rotating (T-FRP) from pentagonal pentaphenylpyrrole (PPP) derivatives and diamines. Graph is used to elucidate geometry these T-FRP, which represent new family polyhedra. The phenyl flipping PPP faces in T-FRP significantly...
The efficient CO
ConspectusMolecular polyhedral cages, notable for their enclosed inner cavities, can possess varying degrees of symmetry, spanning from regular Platonic polyhedra to lower symmetry forms that may display chirality. Crafting chiral molecular cages typically involves using building blocks containing stereogenic elements or arranging achiral components in a manner lacks mirror and inversion symmetries. Achieving precise control over chirality poses both significance challenges.In this Account,...
In the realm of nanoscale materials design, achieving precise control over dimensions nanotubular architectures poses a substantial challenge. our ongoing pursuit, we have successfully engineered novel class single-molecule nanotubes─isoreticular covalent organic pillars (iCOPs)─by stacking formylated macrocycles through multiple dynamic imine bonds, guided by principles reticular chemistry. Our strategic selection rigid diamine linkers has facilitated synthesis diverse array iCOPs, each...
Fluorenone derivatives represent promising candidates for electron-transport materials in organic electronic devices. Given that anionic species serve as electron-transfer carriers materials, it is highly desirable to isolate and characterize the radical anions dianions of indenofluorened (IFO). In this work, reduction three indenofluorenedione (IFO, 1, 2 3) with potassium resulted anion salts (1K[(crypt-222)], 2K[(crypt-222)] 3K) one dianion salt (2[K(crypt-222)]2). Single-crystal X-ray...
The rational design of stimuli-responsive materials requires a deep understanding the structure-activity relationship. Herein, we proposed an intramolecular conformation-locking strategy─incorporating flexible tetraphenylethylene (TPE) luminogens into rigid scaffold molecular cage─to produce photoswitch with dual outputs luminescence and photochromism in solution solid states at once. cage scaffold, which restricts rotations TPE moiety, not only helps to preserve dilute but facilitates...
Glycosylation is known as a critical biological process that can largely affect the properties and functions of proteins. Glycan isomers have been shown to be involved in variety disease progressions. However, separation identification glycan has challenge for years due microheterogeneity isomeric structures. Therefore, effective stable techniques investigated over last few decades improve separations glycans. RPLC widely used biomolecule analysis because its extraordinary reproducibility...
Glycosylation is an important post-translational modification of proteins. Many diseases, such as cancer, have proved to be related aberrant glycosylation. High throughput quantitative methods gained attention recently in the study glycomics. With development high-resolution mass spectrometry, sensitivity detection glycomics has largely improved; however, most commonly used MS-based techniques are focused on relative analysis, which can hardly provide direct comparative glycomic quantitation...
As populations age, the number of patients sustaining traumatic brain injury (TBI) and concomitantly receiving preinjury antiplatelet therapy such as aspirin (ASA) clopidogrel (CLOP) is rising. These drugs have been linked with unfavorable clinical outcomes following TBI, where exact mechanism(s) involved are still unknown. In this novel work, we aimed to identify compare altered proteome profile imposed by ASA CLOP when administered alone or in combination, prior experimental TBI....
Retention time normalization of permethylated glycans and glycan isomers across different instruments laboratories, using standard dextrin ladder. (Figure created with BioRender.com).