- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Neonatal Respiratory Health Research
- Anesthesia and Sedative Agents
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obstructive Sleep Apnea Research
- Anesthesia and Neurotoxicity Research
- Hemodynamic Monitoring and Therapy
- Thermal Regulation in Medicine
- Cerebrospinal fluid and hydrocephalus
- Inhalation and Respiratory Drug Delivery
- Traumatic Brain Injury and Neurovascular Disturbances
- Patient Safety and Medication Errors
- Viral Infections and Vectors
- Emergency and Acute Care Studies
- Cardiovascular and Diving-Related Complications
- Cardiovascular Function and Risk Factors
- Intensive Care Unit Cognitive Disorders
- Healthcare Technology and Patient Monitoring
- Cardiac Arrest and Resuscitation
- Respiratory viral infections research
Uppsala University
2014-2023
Mälardalen University
2023
Västmanlands sjukhus Västerås
2014-2022
Västerås Municipality
2010-2020
Örebro University
2019
Sahlgrenska University Hospital
2019
University of Ferrara
2019
Committee on Publication Ethics
2018
Annual Reviews
2018
Center for Clinical Research (United States)
2018
Background The use of 100% oxygen during induction anesthesia may produce atelectasis. authors investigated how different concentrations affect the formation atelectasis and fall in arterial saturation apnea. Methods Thirty-six healthy, nonsmoking women were randomized to breathe 100, 80, or 60% for 5 min general anesthesia. Ventilation was then withheld until saturation, assessed by pulse oximetry, decreased 90%. Atelectasis studied with computed tomography. Results a transverse scan near...
Background: Atelectasis is a common consequence of pre-oxygenation with 100% oxygen during induction anaesthesia. Lowering the level reduces atelectasis. Whether this effect maintained anaesthesia unknown. Methods: During and after 60%, 80% or concentration, followed by mechanical ventilation 40% in nitrogen positive end-expiratory pressure 3 cmH2O, we used repeated computed tomography (CT) to investigate early (0–14 min) vs. later time course (14–45 atelectasis formation. Results: In...
Various methods for protective ventilation are increasingly being recommended patients undergoing general anesthesia. However, the importance of each individual component is still unclear. In particular, perioperative use positive end-expiratory pressure (PEEP) remains controversial. The authors tested hypothesis that PEEP alone would be sufficient to limit atelectasis formation during nonabdominal surgery.This was a randomized controlled evaluator-blinded study. Twenty-four healthy...
Abstract Editor’s Perspective What We Already Know about This Topic Article Tells Us That Is New Background Anesthesia is increasingly common in elderly and overweight patients prompted the current study to explore mechanisms of age- weight-dependent worsening arterial oxygen tension (Pao2). Methods a primary analysis pooled data with (1) American Society Anesthesiologists (ASA) classification 1; (2) normal forced vital capacity; (3) preoxygenation an inspired fraction (Fio2) more than 0.8...
Background. Atelectasis is common during and after general anaesthesia. We hypothesized that a ventilation strategy, without recruitment manoeuvres, using combination of continuous positive airway pressure (CPAP) or end-expiratory (PEEP) reduced oxygen fraction (FETO2) before ending mask with CPAP extubation would reduce the area postoperative atelectasis. Methods. Thirty patients were randomized into three groups. During induction emergence, inspiratory fractions (FIO2) 1.0 in...
Background Atelectasis is common during and after general anaesthesia. We hypothesized that a ventilation strategy with combination of 1) continuous positive airway pressure ( CPAP ) or end‐expiratory PEEP 2) reduced oxygen concentration recovery would reduce post‐operative atelectasis. Methods Sixty patients were randomized into two groups. During anaesthesia induction, inspiratory fraction F I O 2 was 1.0, depending on weight, 6, 7 8 cmH applied in both groups via facemask. maintenance...
Background Venous admixture from atelectasis and airway closure impedes oxygenation during general anaesthesia. We tested the hypothesis that continuous positive pressure ( CPAP ) pre‐oxygenation reduced fraction of inspiratory oxygen FIO 2 emergence anaesthesia can improve in patients with obesity undergoing laparoscopic surgery. Methods In intervention group n = 20, median BMI 41.9), a 10 cmH O was used induction anaesthesia, but no control 38.1). During all were ventilated...
Following preoxygenation and induction of anaesthesia, most patients develop atelectasis. We hypothesized that an immediate restoration to a low oxygen level in the alveoli would prevent atelectasis formation improve oxygenation during ensuing anaesthesia.We randomly assigned 24 either control group (n = 12) or intervention receiving washout procedure directly after intubation. Both groups were, depending on body mass index, ventilated with positive end-expiratory pressure (PEEP) 6-8 cmH2O...
Positive end-expiratory pressure (PEEP) increases lung volume and protects against alveolar collapse during anesthesia. During emergence, safety preoxygenation preparatory to extubation makes the susceptible gas absorption collapse, especially in dependent regions being kept open by PEEP. We hypothesized that withdrawing PEEP before starting emergence would limit postoperative atelectasis formation.This was a randomized controlled evaluator-blinded trial 30 healthy patients undergoing...
BACKGROUND Face mask ventilation (FMV) during induction of anaesthesia is associated with risk gastric insufflation that may lead to regurgitation and pulmonary aspiration. A continuous positive airway pressure (CPAP) has been shown reduce regurgitation. We therefore hypothesised CPAP followed by FMV end-expiratory (PEEP) would the insufflation. OBJECTIVE The primary aim was compare incidence a fixed PEEP level or zero (ZEEP) after induction. secondary investigate effects without on upper...
Objectives This study aimed to assess whether trigger tools were useful identifying triage errors among patients referred non-emergency care by emergency medical dispatch nurses, and describe the characteristics of these patients. Design An observational nurses care. Setting Dispatch centres in two Swedish regions. Participants A total 1089 adult directed between October 2016 February 2017. 53% female median age was 61 years. Primary secondary outcome measures The primary a visit an...
We read with expectations the study "Individualized Positive End-expiratory Pressure on Postoperative Atelectasis in Patients Obesity: A Randomized Controlled Clinical Trial," by Li et al.1 congratulate authors for succeeding completing this interesting despite COVID-19 pandemic. The is one of a few that have managed to use computed tomography assess amount early postoperative atelectasis after using an intraoperative protective ventilation strategy. In study, there was small but...
BACKGROUND Positive end-expiratory pressure (PEEP) is important to increase lung volume and counteract airway closure during anaesthesia, especially in obese patients. However, maintaining PEEP emergence preoxygenation might postoperative atelectasis by allowing susceptible areas be filled with highly absorbable oxygen that gets entrapped when small airways collapse due the sudden loss of at extubation. OBJECTIVE This study aimed test hypothesis withdrawing just before would better maintain...
Pressure-controlled face mask ventilation (PC-FMV) with positive end-expiratory pressure (PEEP) after apnoea following induction of general anaesthesia prolongs safe time and reduces atelectasis formation. However, depending on the set inspiratory pressure, a delayed confirmation patent airway might occur. We hypothesised that by lowering peak (PIP) when using PC-FMV PEEP, would not be as studied first return CO2 , compared manual (Manual FMV).This was single-centre, randomised controlled...