A5087047490- Salivary Gland Disorders and Functions
- Oral microbiology and periodontitis research
- Oral Health Pathology and Treatment
- Herpesvirus Infections and Treatments
- Dental Anxiety and Anesthesia Techniques
- Head and Neck Cancer Studies
- Cytomegalovirus and herpesvirus research
- Oral and gingival health research
- Dental Education, Practice, Research
- Atrial Fibrillation Management and Outcomes
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Dental Radiography and Imaging
- HIV/AIDS oral health manifestations
- Endodontics and Root Canal Treatments
- Toxin Mechanisms and Immunotoxins
- Dental Health and Care Utilization
- Infective Endocarditis Diagnosis and Management
- Blood Pressure and Hypertension Studies
- Virus-based gene therapy research
- Opioid Use Disorder Treatment
- Pain Mechanisms and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Venous Thromboembolism Diagnosis and Management
- Dental Implant Techniques and Outcomes
- Cancer Diagnosis and Treatment
University of Kentucky
2016-2025
Children's Healthcare of Atlanta
2024
ORCID
2024
Albert B. Chandler Hospital
1991-2019
Kent State University
2019
Marymount University
2015-2016
Craig Technologies (United States)
2015
Kaiser Permanente
2014
Hillcrest Hospital
2008
Lexington VA Health Care System
2007
In the last decade, saliva has been advocated as a non-invasive alternative to blood diagnostic fluid. However, use of hindered by inadequate sensitivity current methods detect lower salivary concentrations many constituents compared serum. Furthermore, developments in areas related lab-on-a-chip systems for saliva-based point care diagnostics are complicated high viscocity and heterogeneous properties associated with this The biomarker C-reactive protein (CRP) is an acute phase reactant...
Sexton WM, Lin Y, Kryscio RJ, Dawson III DR, Ebersole JL, Miller CS. Salivary biomarkers of periodontal disease in response to treatment. J Clin Periodontol 2011; 38: 434–441. doi: 10.1111/j.1600-051X.2011.01706.x Background: periodontitis were assessed longitudinally determine therapy. Methods: A 6-month case-controlled study adults with chronic was performed, 33 participants receiving oral hygiene instructions (OHI) alone and 35 scaling root planing (SRP) combined OHI. Saliva samples...
Abstract Background: For adults with chest pain, the electrocardiogram (ECG) and measures of serum biomarkers are used to screen diagnose myocardial necrosis. These measurements require time that can delay therapy affect prognosis. Our objective was investigate feasibility utility saliva as an alternative diagnostic fluid for identifying acute infarction (AMI). Methods: We Luminex lab-on-a-chip methods assay 21 proteins in unstimulated whole procured from 41 AMI patients within 48 h pain...
The pathophysiology of burning mouth disorder (BMD) is not clearly understood, but central neuropathic mechanisms are thought to be involved. aim this study was gain insight into the associated with BMD by using functional magnetic resonance imaging (fMRI). Areas brain activation following thermal stimulation trigeminal nerve eight female patients (mean age 49.1 ± 10.1) were mapped fMRI and compared those matched pain-free volunteers 50.3 12.3). Qualitative quantitative differences in...
Generally, clinical parameters are used in dental practice for periodontal disease, yet several drawbacks exist with the standards addressing needs of public at large determining current status/progression and requiring a significant amount damage before these can document disease. Therefore, quick, easy reliable method assessing monitoring disease should provide important diagnostic information that improves speeds treatment decisions moves field closer to individualized point-of-care...
Abstract : Salivary secretions contain a variety of molecules that reflect important pathophysiological activities. Quantitative changes specific salivary biomarkers could have significance in the diagnosis and management both oral systemic diseases. Modern point‐of‐care technologies with enhanced detection capabilities are needed to implement significant advancement diagnostics. One such promising technology is recently described lab‐on‐a‐chip (LOC) assay system, which assays performed on...
To test the hypothesis that rheumatoid arthritis (RA) influenced levels of salivary biomarkers periodontal disease.Medical assessments, examinations and pain ratings were obtained from 35 RA, chronic periodontitis age- gender-matched healthy controls in a cross-sectional, case-controlled study. Unstimulated whole saliva samples analysed for interleukin-1β (IL-1β), matrix metalloproteinase-8 (MMP-8) tumour necrosis factor-α (TNF-α) concentrations.The groups had significantly less oral disease...
Background: Salivary biomarkers are potentially important for determining the presence, risk, and progression of periodontal disease. However, clinical translation biomarker technology from lab to chairside requires studies that identify associated with transitional phase between health disease (i.e., gingivitis). Methods: Eighty participants (40 gingivitis, 40 healthy) provided saliva at baseline 7 30 days later. An additional sample was collected gingivitis 10 after dental prophylaxis....
ABSTRACT Human immunodeficiency virus (HIV) infection is associated with an increased risk for human herpesviruses (HHVs) and their related diseases. Methods limiting the transmission of HHVs require a better understanding prevalence infectiousness oral in HIV-infected patients. We performed quantitative PCR to investigate prevalence, quantity, risk, correlates salivary from 58 HIV-seropositive individuals case control study. were significantly more prevalent salivas persons than those...
We explored the consequences for learning through interaction with an educational microworld called Electric Field Hockey (EFH). Like many microworlds, EFH is intended to help students develop a qualitative understanding of target domain, in this case, physics electrical interactions. Through development and use computer model that learns play EFH, we analyzed knowledge acquired as it applied game-oriented strategies observed using. learning-by-doing on standard sequence tasks, substantially...
Background: Tumor necrosis factor‐alpha (TNF‐α), C‐telopeptide pyridinoline cross‐links of type I collagen (ICTP), and receptor activator nuclear factor‐kappa B ligand (RANKL) have been associated with bone remodeling periodontal tissue destruction. This study evaluated the level these biomarkers in saliva respect to disease status. Methods: Levels TNF‐α unstimulated whole 74 adults (35 subjects moderate severe 39 healthy controls) salivary levels RANKL ICTP a subset 21 matched controls were...
The records of 5,000 dental patients were reviewed for history verapamil use between 1987 and 1990. Twenty-four dentate who received more than 1 year identified. Of these, gingival hyperplasia occurred in patient (4.1%) that was limited to the mandibular attached gingiva. Onset overgrowth associated with drug dosage, bacterial accumulation, inflammation. Histologically, findings resembled seen induced by phenytoin, cyclosporin, other calcium channel blockers. Our data suggest caused occurs...
Al‐Sabbagh M, Alladah A, Lin Y, Kryscio RJ, Thomas MV, Ebersole JL, Miller CS. Bone remodeling‐associated salivary biomarker MIP‐1α distinguishes periodontal disease from health. J Periodont Res 2012; 47: 389–395. © 2011 John Wiley & Sons A/S Background and Objective: The field of diagnostics lacks an accepted validated alveolar bone remodeling. To address this, we examined levels biomolecules specifically associated with biological aspects remodeling in subjects chronic periodontitis a...
Objective JC virus (JCV) seropositivity is a risk factor for progressive multifocal leukoencephalopathy (PML) in patients on natalizumab. Accordingly, the JCV serological antibody test of paramount importance determining disease risk. Methods We tested accuracy serum by comparing results serology to viruria and viremia 67 enrolled single‐center, retrospective cohort study. Bodily fluids (urine blood) were assessed DNA real time quantitative polymerase chain reaction 6 47 months (mean = 26.1...