A5013096129- Oral microbiology and periodontitis research
- Salivary Gland Disorders and Functions
- Oral Health Pathology and Treatment
- Immune Response and Inflammation
- HIV/AIDS oral health manifestations
- Oral and gingival health research
- Streptococcal Infections and Treatments
- Dental Health and Care Utilization
- Antimicrobial Peptides and Activities
- T-cell and B-cell Immunology
- Gut microbiota and health
- Monoclonal and Polyclonal Antibodies Research
- Endodontics and Root Canal Treatments
- Pediatric health and respiratory diseases
- Cell Adhesion Molecules Research
- Diabetes and associated disorders
- Bone and Dental Protein Studies
- Infant Nutrition and Health
- Periodontal Regeneration and Treatments
- Dental Radiography and Imaging
- Glycosylation and Glycoproteins Research
- Microbial infections and disease research
- dental development and anomalies
- Blood groups and transfusion
- NF-κB Signaling Pathways
University of Nevada, Las Vegas
2018-2025
University of Kentucky
2014-2023
Harvard University
1939-2023
University of California, San Francisco
2023
University of Connecticut
2023
University of Michigan
2023
University of Maryland, College Park
2023
University at Buffalo, State University of New York
2023
University of Nevada, Reno
2022
Las Vegas Institute
2019
Although periodontitis is a bacterial disease, its multidimensional nature and complexity have made it difficult to definitively prove that specific microorganisms initiate the disease process. The successful implantation of rifampin-resistant strain putative periodontal pathogen Bacteroides gingivalis into microbiota monkeys ( Macaca fascicularis ) resulted in an increase systemic levels antibody microorganism rapid significant bone loss.
Capture ELISAs with biotinylated monospecific antibodies were developed to detect both C-reactive protein (CRP) and haptoglobin (Hp) in serum of adult periodontitis (AP) patients normal subjects. Each acute-phase reactant was significantly increased from AP CRP at 9.12 +/- 1.61 mg/l versus 2.17 0.41 (P < 0.001) Hp 3.68 0.37 g/l 1.12 0.78 0.001). Assessment clinical characteristics the patients' periodontal disease indicated that levels most frequent active episodes 0.02 P 0.001,...
Abstract Background Chronic inflammation in periodontal disease has been suggested as a potential risk factor Alzheimer's (AD). The purpose of this study was to examine serum antibody levels bacteria participants who eventually converted AD compared with the control subjects. Methods Serum samples from 158 Biologically Resilient Adults Neurological Studies research program at University Kentucky were analyzed for immunoglobulin G seven oral associated periodontitis, including Aggregatibacter...
Abstract 76 subjects with prior evidence of destructive periodontal diseases were monitored clinically and immunologically every 2 months for up to 5 years. Clinical parameters measured included bleeding on probing, gingival redness. plaque accumulation, suppuration, pocket depth attachment level. Blood samples taken by venipuncture serum antibody levels a series 18 subgingival species determined. 33 these showed active disease during the monitoring period, based changes in level...
One of the predominant polymicrobial infections humans is expressed clinically as periodontal disease. Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia have been strongly implicated members a pathogenic consortium in etiology adult periodontitis. In this study we hypothesized that P. T. are synergistic terms virulence potential induce chronic inflammation leads to alveolar bone resorption infection rats. Groups rats were infected with either or monomicrobial all three...
Sexton WM, Lin Y, Kryscio RJ, Dawson III DR, Ebersole JL, Miller CS. Salivary biomarkers of periodontal disease in response to treatment. J Clin Periodontol 2011; 38: 434–441. doi: 10.1111/j.1600-051X.2011.01706.x Background: periodontitis were assessed longitudinally determine therapy. Methods: A 6-month case-controlled study adults with chronic was performed, 33 participants receiving oral hygiene instructions (OHI) alone and 35 scaling root planing (SRP) combined OHI. Saliva samples...
Abstract Background: For adults with chest pain, the electrocardiogram (ECG) and measures of serum biomarkers are used to screen diagnose myocardial necrosis. These measurements require time that can delay therapy affect prognosis. Our objective was investigate feasibility utility saliva as an alternative diagnostic fluid for identifying acute infarction (AMI). Methods: We Luminex lab-on-a-chip methods assay 21 proteins in unstimulated whole procured from 41 AMI patients within 48 h pain...
Generally, clinical parameters are used in dental practice for periodontal disease, yet several drawbacks exist with the standards addressing needs of public at large determining current status/progression and requiring a significant amount damage before these can document disease. Therefore, quick, easy reliable method assessing monitoring disease should provide important diagnostic information that improves speeds treatment decisions moves field closer to individualized point-of-care...
Abstract : Salivary secretions contain a variety of molecules that reflect important pathophysiological activities. Quantitative changes specific salivary biomarkers could have significance in the diagnosis and management both oral systemic diseases. Modern point‐of‐care technologies with enhanced detection capabilities are needed to implement significant advancement diagnostics. One such promising technology is recently described lab‐on‐a‐chip (LOC) assay system, which assays performed on...
Abstract Aim Variations in the expression of cytokines during progression periodontitis remain ill‐defined. We evaluated 19 cytokine genes related to T‐cell phenotype/function initiation, and resolution periodontitis, these soft bone tissue destruction ( TDG s). Materials Methods A ligature‐induced model was used rhesus monkeys M. mulatta ) n = 18). Gingival tissues were taken at baseline pre‐ligation, 2 weeks 1 month (Initiation) 3 months (progression) post ligation. Ligatures removed...
To test the hypothesis that rheumatoid arthritis (RA) influenced levels of salivary biomarkers periodontal disease.Medical assessments, examinations and pain ratings were obtained from 35 RA, chronic periodontitis age- gender-matched healthy controls in a cross-sectional, case-controlled study. Unstimulated whole saliva samples analysed for interleukin-1β (IL-1β), matrix metalloproteinase-8 (MMP-8) tumour necrosis factor-α (TNF-α) concentrations.The groups had significantly less oral disease...
Background: Salivary biomarkers are potentially important for determining the presence, risk, and progression of periodontal disease. However, clinical translation biomarker technology from lab to chairside requires studies that identify associated with transitional phase between health disease (i.e., gingivitis). Methods: Eighty participants (40 gingivitis, 40 healthy) provided saliva at baseline 7 30 days later. An additional sample was collected gingivitis 10 after dental prophylaxis....