A5060726776- Oral microbiology and periodontitis research
- Oral Health Pathology and Treatment
- Oral and gingival health research
- Immune Response and Inflammation
- Salivary Gland Disorders and Functions
- HIV/AIDS oral health manifestations
- Periodontal Regeneration and Treatments
- Dental Radiography and Imaging
- Streptococcal Infections and Treatments
- Dental Health and Care Utilization
- NF-κB Signaling Pathways
- Protease and Inhibitor Mechanisms
- Oral and Maxillofacial Pathology
- T-cell and B-cell Immunology
- Antimicrobial Peptides and Activities
- Blood groups and transfusion
- Immunodeficiency and Autoimmune Disorders
- S100 Proteins and Annexins
- Dental Implant Techniques and Outcomes
- dental development and anomalies
- Cell Adhesion Molecules Research
- Endodontics and Root Canal Treatments
- Cardiovascular Effects of Exercise
- Dental materials and restorations
- Bone and Dental Protein Studies
University of Bern
2020-2024
University of Pennsylvania
2010-2020
University of Geneva
2011-2020
Philadelphia University
2018
In-Q-Tel
2015
University of Louisville
2003-2014
University of Louisville Hospital
2007-2013
Dean College
2002-2010
Meikai University
2005
University of Glasgow
1993-2003
A new periodontitis classification scheme has been adopted, in which forms of the disease previously recognized as "chronic" or "aggressive" are now grouped under a single category ("periodontitis") and further characterized based on multi-dimensional staging grading system. Staging is largely dependent upon severity at presentation well complexity management, while provides supplemental information about biological features including history-based analysis rate progression; assessment risk...
Abstract A new periodontitis classification scheme has been adopted, in which forms of the disease previously recognized as “chronic” or “aggressive” are now grouped under a single category (“periodontitis”) and further characterized based on multi‐dimensional staging grading system. S taging is largely dependent upon severity at presentation well complexity management, while provides supplemental information about biological features including history‐based analysis rate progression;...
Abstract Matrix metalloproteinases (MMPs) and serine proteinases seem to be related tissue destruction in periodontitis. The presence of MMPs gingival crevicular fluid (GCF) saliva, however, has not been studied comprehensively with the enzyme‐linked immunosorbent assay (ELISA)‐technique, We therefore examined levels MMP‐1,‐3.‐8 ‐9, their endogenous inhibitor, inhibitor matrix (TIMP‐1). GCF saliva patients adult periodontitiss (AP) localized juvenile periodontitis (LJP). Elevated MMP‐1 were...
Abstract Introduction: Transient bacteraemias are frequently detected following dental manipulation. Infective endocarditis (IE) can arise in susceptible individuals and antibiotic prophylaxis is routinely performed for certain procedures considered to be “at risk” of IE. Evidence emerging that periodontal disease may a significant risk factor the development systemic diseases such as cardiovascular disease. These conditions could initiated or detrimentally influenced by repeated entry...
Plasma fibrinogen and white blood cell count were compared in fifty patients aged 25–50 years with periodontal disease age-matched controls relatively healthy tissues. Patients had significantly higher levels of count, dental indices correlated these two cardiovascular risk factors on multivariate analyses. We suggest that inflammatory may be a determinant level the general population, mediators link between myocardial infarction.
Background: A rapid chair‐side test based on the immunological detection of elevated levels collagenase‐2 (matrix metalloproteinase‐8, MMP‐8) in gingival crevicular fluid (GCF) was developed to identify and monitor course treatment adult periodontitis. Methods: MMP‐8 determined GCF from periodontitis (11 patients, 90 sites), gingivitis (10 58 sites) healthy control (8 59 sites (i) by a stick incorporating monoclonal antibodies two epitopes (ii) measuring concentration quantitative...
Abstract Background: Interleukin‐17 (IL‐17) is exclusively produced by activated T cells, and this cytokine can induce inflammatory responses, support immune responses (Th1), stimulate osteoclastic bone resorption in combination with receptor activator of NF‐ κ B (RANK) RANK ligand (RANKL). These biological functions are relevant to the aetiopathogenesis periodontitis, thus we sought investigate whether IL‐17 periodontal lesions assess relationship gene expression between other cytokines,...
Abstract Background: For adults with chest pain, the electrocardiogram (ECG) and measures of serum biomarkers are used to screen diagnose myocardial necrosis. These measurements require time that can delay therapy affect prognosis. Our objective was investigate feasibility utility saliva as an alternative diagnostic fluid for identifying acute infarction (AMI). Methods: We Luminex lab-on-a-chip methods assay 21 proteins in unstimulated whole procured from 41 AMI patients within 48 h pain...
Abstract Introduction: The remit of this group was to update the knowledge base on periodontal diseases and health. Material Methods: literature systematically searched critically reviewed in five specific topics. Results: Prevalence periodontitis: data suggest a trend towards lower prevalence periodontitis recent years. Adverse pregnancy outcome: findings indicate likely association between disease an increased risk adverse outcomes. There is no evidence that treating decreases rate...
Abstract Objectives: The aim of the current study was to assess impact smoking on clinical indices, humoral immune response and detection frequency putative periodontal pathogens in patients with periodontitis cross‐sectionally following therapy. Material Methods: Clinical measurements, subgingival plaque samples, gingival crevicular fluid (GCF) sera were collected from 40 untreated moderate‐to‐advanced chronic before after treatment over a period 6 months. consisted initial therapy scaling...
Abstract Background: Major challenges in periodontology include understanding the pathophysiology, interplay between various components of host response, parallels with other diseases and identifying biomarkers disease. Objectives: Four reviews were compiled aim better understanding: (1) role polymorphic nuclear leucocytes (PMNs), i.e. neutrophils; (2) function cytokine networks response; (3) whether exist rheumatoid arthritis (RA); (4) useful currently to help management periodontal...
ABO blood group and secretor state was determined in 319 women with recurrent urinary tract infection compared those of a control 334 similar age ranges. Women groups B AB who are non-secretors substances showed significant relative risk 3.12 (95% confidence limits, 1.49 6.52) comparison other types. This appears to be genuine example synergy which absence anti-B isohaemagglutinin combines give an increased infection. Determination may provide additional information identifying at risk.
Mammalian biological processes such as inflammation, involve regulation of hundreds genes controlling onset and termination. MicroRNAs (miRNAs) can translationally repress target mRNAs regulate innate immune responses. Our model system comprised primary human keratinocytes, which exhibited robust differences in inflammatory cytokine production (interleukin-6 tumor necrosis factor-alpha) following specific Toll-like receptor 2 4 (TLR-2/TLR-4) agonist challenge. We challenged these cells with...
Background: This study was performed to evaluate the effects of initial periodontal treatment on clinical measurements, glycemic control, and systemic inflammatory mediator levels in patients with type 2 diabetes chronic periodontitis. Methods: Thirteen well‐controlled (glycated hemoglobin [HbA1c] <7%) 12 poorly controlled (HbA1c ≥7%) periodontitis 15 systemically healthy were enrolled. Blood samples collected at baseline from all 1 3 months after diabetes. Serum tumor necrosis factor...
Özçaka Ö, Başoğlu ÖK, Buduneli N, Taşbakan MS, Bacakoğlu F, Kinane DF. Chlorhexidine decreases the risk of ventilator‐associated pneumonia in intensive care unit patients: a randomized clinical trial. J Periodont Res 2012; 47: 584–592. © 2012 John Wiley & Sons A/S Background and Objective: The aim was to evaluate whether oral swabbing with 0.2% chlorhexidine gluconate (CHX) (VAP) (ICU) patients. Material Methods: Sixty‐one dentate patients scheduled for invasive mechanical ventilation at...
Abstract Background Anti‐citrullinated protein antibody ( ACPA ) responses may precede clinical onset of rheumatoid arthritis. Porphyromonas gingivalis peptidylarginine deiminase can citrullinate proteins possibly inducing autoimmunity in susceptible individuals. Aim To determine whether periodontitis, carriage P. gingivalis, smoking and periodontal therapy influence titres. Methods Serum plaque samples were collected from 39 periodontitis patients before after non‐surgical treatment, 36...