A5101415522- Spinal Dysraphism and Malformations
- Extracellular vesicles in disease
- RNA Research and Splicing
- Immune cells in cancer
- Cerebrospinal fluid and hydrocephalus
- Neonatal and fetal brain pathology
- Macrophage Migration Inhibitory Factor
- RNA modifications and cancer
- Nuclear Receptors and Signaling
Xiamen University
2020
Guangdong Pharmaceutical University
2019
Significance It is still a great challenge to identify novel therapeutic strategies for breast cancer, especially those with treatment resistance. was demonstrated here that nuclear receptor Nur77 an effective drug target cancer and compound Csn-B clinically relevant by binding prevent peroxisome proliferator-activated receptor-γ (PPARγ) targeting steric hindrance, thereby inhibiting fatty acid uptake in cells mouse models. Clinical sample analysis further supported the opposing roles of...
This study aimed to investigate the clearance pathways of lamotrigine (LTG)-loaded micelles by intranasal administration and intracerebral injection in brain whether nanoparticles can induce inflammation promoted interleukin-6 (IL-6), accelerating phagocytosis drug particles drainage through lymphatics.The concentrations deep cervical lymph node, superficial tissues jugular vein, pharmacokinetic parameters, IL-6 node were investigated following UPLC/MS, DAS3.0, ELISA statistically...