A5021602155- Photosynthetic Processes and Mechanisms
- Plant Molecular Biology Research
- Galectins and Cancer Biology
- Monoclonal and Polyclonal Antibodies Research
- Light effects on plants
- Glycosylation and Glycoproteins Research
- Plant nutrient uptake and metabolism
- Toxin Mechanisms and Immunotoxins
- Algal biology and biofuel production
- Estrogen and related hormone effects
- Salivary Gland Tumors Diagnosis and Treatment
- Amino Acid Enzymes and Metabolism
- Plant Gene Expression Analysis
- Evolution and Genetic Dynamics
- Reproductive System and Pregnancy
- Salivary Gland Disorders and Functions
- Microbial Metabolic Engineering and Bioproduction
- Plant Stress Responses and Tolerance
- Effects and risks of endocrine disrupting chemicals
- Metabolism and Genetic Disorders
- Plant Reproductive Biology
- Blood groups and transfusion
- Supramolecular Self-Assembly in Materials
Willows Veterinary Centre and Referral Service
2024
Heinrich Heine University Düsseldorf
2012-2022
Ludwig-Maximilians-Universität München
2008-2014
LMU Klinikum
2014
Olgahospital
2014
Cluster of Excellence on Plant Sciences
2013
Klinik für Frauenheilkunde
2008-2011
Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe
2008-2011
München Klinik
2009
Klinikum rechts der Isar
2008
C4 photosynthesis is nature's most efficient answer to the dual activity of ribulose-1,5-bisphosphate carboxylase/oxygenase and resulting loss CO2 by photorespiration. Gly decarboxylase (GDC) key component photorespiratory release in plants active all photosynthetic tissues C3 plants, but only bundle sheath cells plants. The restriction GDC assumed be an essential early step evolution photosynthesis, leading a concentrating mechanism. In this study, we analyzed how P-protein (GLDP) became...
The mitochondrial Gly decarboxylase complex (GDC) is a key component of the photorespiratory pathway that occurs in all photosynthetically active tissues C(3) plants but restricted to bundle sheath cells C(4) species. GDC also required for general cellular C(1) metabolism. In Asteracean species Flaveria trinervia, single functional GLDP gene, GLDPA, encodes P-subunit GDC, decarboxylating dehydrogenase. GLDPA promoter reporter gene fusion studies revealed this and vasculature transgenic...
The first two reactions of C4 photosynthesis are catalysed by carbonic anhydrase (CA) and phosphoenolpyruvate carboxylase (PEPC) in the leaf mesophyll (M) cell cytosol. Translatome experiments using a tagged ribosomal protein expressed under control M bundle-sheath (BS) cell-specific promoters showed transcripts encoding CA3 from species Flaveria bidentis were highly enriched polysomes cells relative to those BS. Localisation employing CA3-green fluorescent fusion F. is cytosolic enzyme. A...
C4 photosynthetic plants have evolved from C3 ancestors and are characterized by differential expression of several hundred genes. Strict compartmentalization key enzymes either to mesophyll (M) or bundle sheath cells is considered a crucial step towards the evolution photosynthesis. In this study, we demonstrate that 5'-flanking sequences type phosphoenolpyruvate carboxylase (Ppc) gene three grass species could drive M-cell-specific reporter in rice. addition that, identified about 450 bp...
A 3 yr old female spayed Labrador retriever was referred for the treatment of a chronic oropharyngeal stick injury. After computed tomography scan evaluation, cervical area explored surgically and right-sided abscess that contained wooden identified adjacent to vagosympathetic trunk carotid artery. The ipsilateral mandibular salivary gland resected concurrently given its abnormal appearance, histology confirmed inflammation necrosis gland, which suspected be due direct trauma from foreign...
Abstract In an effort to identify genetic regulators for the cell ontogeny around veins in Arabidopsis thaliana leaves, activation-tagged mutant line with altered leaf morphology and bundle sheath anatomy was characterized. This had a small rosette area wrinkled leaves chlorotic edges, as well enhanced chloroplast numbers (pre-)bundle tissue. It bundle-specific promoter from gene GLYCINE DECARBOXYLASE SUBUNIT-T C4 species Flaveria trinervia (GLDTFt promoter) inserted coding region of...
Abstract A key feature of C 4 Kranz anatomy is the presence an enlarged, photosynthetically highly active bundle sheath whose cells contain large numbers chloroplasts. With aim to identify novel candidate regulators development, we performed activation tagging screen with Arabidopsis thaliana . The reporter gene used encoded a chloroplast‐targeted GFP protein preferentially expressed in sheath, and promoter phospho enol pyruvate carboxylase from Flaveria trinervia served as tag because its...
Fragestellung: Ein mögliches Zielmolekül für eine antikörperbasierte Therapie bei Patientinnen mit Brustkrebs ist Mucin1 bzw. das tumorassoziierte Epitop von (TA-MUC1), nahezu ausschließlich tumorassoziiert, membranständig und als funktionale RTK vorliegt. Der mittlerweile humanisierte Antikörper PankoMab-GEX TM zeigt allen Mucin-Antikörpern die höchste Abhängigkeit der Glykosilierung bindet deshalb dieses sehr spezifisch. In früheren Studien konnten wir bereits zeigen, dass PankoMab-GEX™...
Das Thomsen-Friedenreich-Epitop (TF) ist ein Carbohydrate Antigen mit hoher Tumorspezifität. TF-exprimierende Mammakarzinompatientinnen zeigen im Vergleich zu TF-Negativen, eine höhere Überlebensrate. Es bekannt, dass Galektin-1 (Gal-1) bei Choriokarzinompatienten an TF bindet und in diesen Zellen Signaltransduktionskaskade induziert. Der Zweck unserer Untersuchungen war, die Rolle von Gal-1 positiven/negativen Mammakarzinomzelllinien vitro erforschen.
Fragestellung:α-Tokopherol (Vitamin E) ist bekannt als das wichtigste fettlösliche Antioxidans. Es wird durch 32 kDa schwere α-Tokopherol-Transfer-Protein (α-TTP) in verschiedene Gewebe, u.a. auch der Plazenta, transportiert. Schädigungen reaktive Sauerstoffspezies Plazenta werden seit langem diskutiert. Plazentabezogene Krankheitsbilder, wie eine Präeklampsie oder Fehlgeburt, Zusammenhang gebracht mit oxidativem Stress. Ziel dieser Arbeit war es herauszufinden, welchen Einfluss Oxidativer...
Das Thomsen-Friedenreich-Antigen zählt zu den onkofetalen Kohlehydrat-Antigenen und wird an der Oberfläche zahlreicher Karzinome exprimiert. Es vermittelt Zelladhäsion ist stark immunogen. Untersuchungen von Disseminierten Tumorzellen im Knochenmark (DTZ-KM) zeigten eine Expresion TF bei 98% DTZ. Wir untersuchten Einfluss eines Anti-TF AKs (0–60 μg/ml) Galektin–1 (Gal–1), welches ebenso bindet, auf das Proliferations- u. Apoptoseverhalten humanen Ma-Ca Zellen mit (CAMA–1, MCF7, ZR–75–1,...
Einleitung: Gal–1 bindet an das Thomsen-Friedenreich (TF) Epitop, von Trophoblasttumorzellen BeWo exprimiert wird [1]. Diese Bindung führt zu einer verminderten Hormonproduktion [2]. beeinflusst die Proliferation TF-positiven (BeWo) [3]. Ziel unserer Untersuchungen war, induzierte Syncytiumbildung in Trophoblastzellen und Signaltransduktionskaskade unteruchen.