A5073975613- Immune Cell Function and Interaction
- Gut microbiota and health
- HIV Research and Treatment
- Epigenetics and DNA Methylation
- Cytomegalovirus and herpesvirus research
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
University of Colorado Denver
2021-2022
University of Colorado Anschutz Medical Campus
2021
Abstract Background The etiology of the low-level chronic inflammatory state associated with aging is likely multifactorial, but a number animal and human studies have implicated functional decline gastrointestinal immune system as potential driver. Gut tissue-resident memory T cells play critical roles in mediating protective immunity maintaining gut homeostasis, yet few investigated effect on cell immunity. To determine if impacted CD4 large intestine, we utilized multi-color flow...
Group 3 innate lymphoid cells (ILC3s) in the gut mucosa have long been thought to be noncytotoxic lymphocytes that are critical for homeostasis of intestinal epithelial through secretion IL-22. Recent work using human tonsillar demonstrated ILC3s exposed exogenous inflammatory cytokines a period time acquired expression granzyme B, suggesting under pathological conditions may become cytotoxic. We hypothesized inflammation associated with bacterial exposure might trigger B ILC3s. To test...
Chronic HIV-1 infection results in the sustained disruption of gut homeostasis culminating alterations microbial communities (dysbiosis) and increased translocation. Major questions remain on how interactions between translocating microbes immune cells impact HIV-1-associated pathogenesis. We previously reported that vitro exposure human to enteric commensal bacteria upregulated serine protease cytotoxic marker Granzyme B (GZB) CD4 T cells, GZB expression was further HIV-1-infected cells. To...