A5042039287- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- interferon and immune responses
- Chromosomal and Genetic Variations
- Long-Term Effects of COVID-19
- Infection Control and Ventilation
- Genomic variations and chromosomal abnormalities
- T-cell and B-cell Immunology
- COVID-19 epidemiological studies
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Viral Infections and Immunology Research
University of Colorado Denver
2021-2024
University of Colorado Anschutz Medical Campus
2021-2022
Fort Lewis College
2019
The emergence of SARS-CoV-2 variants with enhanced transmissibility, pathogenesis, and resistance to vaccines presents urgent challenges for curbing the COVID-19 pandemic. While Spike mutations that enhance virus infectivity or neutralizing antibody evasion may drive these novel variants, studies documenting a critical role interferon responses in early control infection, combined presence viral genes limit responses, suggest interferons also influence evolution. Here, we compared potency 17...
Abstract The emergence of SARS-CoV-2 variants with enhanced transmissibility, pathogenesis and resistance to vaccines presents urgent challenges for curbing the COVID-19 pandemic. While Spike mutations that enhance virus infectivity or neutralizing antibody evasion may drive these novel variants, studies documenting a critical role interferon responses in early control infection, combined presence viral genes limit responses, suggest interferons also influence evolution. Here, we compared...
Severe coronavirus disease 2019 (COVID-19) has been associated with T cell lymphopenia, but no causal effect of deficiency on severity established. To investigate the specific role cells in recovery from severe acute respiratory syndrome 2 (SARS-CoV-2) infections, we studied rhesus macaques that were depleted either CD4+, CD8+, or both subsets prior to infection. Peak virus loads similar all groups, resolution cell-depleted animals was slightly delayed compared controls. The groups developed...
Endogenous retroelements (EREs), including human endogenous retroviruses (HERVs) and long interspersed nuclear elements (LINEs), comprise almost half of the genome. Our previous studies interferome in gut suggest potential mechanisms regarding how IFNb may drive HIV-1 pathogenesis. As ERE activity is suggested to partake type 1 immune responses incredibly sensitive viral infections, we sought elucidate underlying interactions between expression dynamics people living with (PLWH).
Chronic HIV-1 infection results in the sustained disruption of gut homeostasis culminating alterations microbial communities (dysbiosis) and increased translocation. Major questions remain on how interactions between translocating microbes immune cells impact HIV-1-associated pathogenesis. We previously reported that vitro exposure human to enteric commensal bacteria upregulated serine protease cytotoxic marker Granzyme B (GZB) CD4 T cells, GZB expression was further HIV-1-infected cells. To...
Abstract Severe COVID-19 has been associated with T cell lymphopenia 1,2 , but no causal effect of deficiency on disease severity established. To investigate the specific role cells in recovery from SARS-CoV-2 infections we studied rhesus macaques that were depleted either CD4 + CD8 or both subsets prior to infection. Peak virus loads similar all groups, resolution cell-depleted animals was slightly delayed compared controls. The groups developed virus-neutralizing antibody responses and...
Essential agricultural workers work under occupational conditions that may increase the risk of SARS-CoV-2 exposure and transmission. Data from an worker cohort in Guatemala, anti-SARS-CoV-2 nucleocapsid IgG (anti-N IgG) testing were used to estimate past infections analyze factors associated with seropositivity at enrollment association infection. The stability neutralizing antibody (NAb) responses assessed a subset participants. adjusted relative (aRR) for seroprevalence was estimated...
SAMHD1 is a potent HIV-1 restriction factor that blocks reverse transcription in monocytes, dendritic cells and resting CD4+ T by decreasing intracellular dNTP pools. However, may diminish innate immune sensing Ag presentation, resulting weaker adaptive response. To date, the role of on antiretroviral immunity remains unclear, as mouse had no impact murine retrovirus replication prior vivo studies. Here, we show significantly inhibits acute Friend infection mice. Pretreatment with LPS,...
Abstract The gastrointestinal tract is ground zero for the massive and sustained CD4 T cell depletion during acute HIV-1 infection. To date, molecular mechanisms governing this fundamental pathogenic process remain unclear. infection in associated with chronic inflammation due to a disrupted epithelial barrier that results microbial translocation. Here, we utilized lamina propria aggregate culture model demonstrate profound induction of granzyme B by bacteria primary gut cells ex vivo...
Summary Background Endogenous retroelements (EREs), including human endogenous retroviruses (HERVs) and long interspersed nuclear elements (LINEs), comprise almost half of the genome. HIV-1 infects a target cell already possessing ancient retroviral genetic material, exogenous infection modulates expression associated EREs. Following initial infection, there is rapid destruction CD4+ cells in gut lymphoid tissue (GALT). Our previous studies interferome suggest potential mechanisms regarding...
CMV is the most common cause of both congenital infection and post‐transplant worldwide. can severe symptoms: pneumonia, encephalitis, inflammation vital organs. There currently no vaccine for CMV. An understanding how progresses from its acute phase to persistence would illuminate features pathogen that could lead novel treatments disease which block virus reaching latency . RNA5.0 a lncRNA produced during infection. Studies using homologous RNA7.2 mouse model has shown when RNA not...