A5037456710- Inflammatory mediators and NSAID effects
- Neonatal Respiratory Health Research
- Pulmonary Hypertension Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Biomarkers in Disease Mechanisms
- Vaccine Coverage and Hesitancy
- Exercise and Physiological Responses
- COVID-19 and Mental Health
- Tissue Engineering and Regenerative Medicine
- Peptidase Inhibition and Analysis
- Eicosanoids and Hypertension Pharmacology
- Angiogenesis and VEGF in Cancer
- Misinformation and Its Impacts
- Adipose Tissue and Metabolism
- Hematological disorders and diagnostics
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Asthma and respiratory diseases
- Venous Thromboembolism Diagnosis and Management
- Phosphodiesterase function and regulation
- TGF-β signaling in diseases
- Macrophage Migration Inhibitory Factor
- Mechanisms of cancer metastasis
- Cardiac Fibrosis and Remodeling
Helwan University
2020-2023
University of Nebraska Medical Center
2010-2017
Assiut University
2013
The California Eye Institute
2008
University of California, Irvine
2008
Baylor College of Medicine
2004-2005
Fatigue of hand and forearm muscle groups can limit task performance by astronauts wearing space suits. Countermeasures to delay fatigue would therefore be useful the program. N-acetylcysteine (NAC) has been shown inhibit during other tasks so we tested its effects handgrip exercise. Volunteers practiced isometric maneuvers until was reproducible over three successive sessions (baseline). Performance then retested after ingesting NAC (150 mg.kg(-1)) or saline. Drug administration increased...
Vitamin D insufficiency has been increasingly recognized in the general population worldwide and associated with several lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), respiratory tract infections. Fibroblasts play a critical role tissue repair remodeling, which is key feature of COPD asthma. modulate by producing modifying extracellular matrix components releasing mediators that act as autocrine or paracrine modulators remodeling. The current study was...
This study tested the hypothesis that skeletal muscle contraction activates nuclear factor-kappaB (NF-kappaB), a putative regulator of protein breakdown. Muscle biopsies were obtained from vastus lateralis healthy humans before, immediately after, and 1 h after fatiguing resistance exercise lower limbs. Biopsies analyzed for NF-kappaB DNA binding activity by using electrophoretic mobility shift assay. activity, measured exercise, was less than preexercise activity; 1-h recovery, returned to...
This study assessed the effect of extended exposure to cigarette smoke extract (CSE) on tissue repair functions in lung fibroblasts. Human fetal (HFL-1) and adult fibroblasts were exposed CSE for 14 days. Senescence-associated β-galactosidase (SA β-gal) expression, cell proliferation, including chemotaxis gel contraction assessed. HFL-1 proliferation was inhibited by nearly half CSE-exposed cells SA β-gal positive after days exposure, whereas 33% response 10% exposure. The β-gal-positive did...
Abstract Background Unloading of skeletal muscle causes atrophy and loss contractile function. In part, this response is believed to be mediated by the transcription factor nuclear factor-kappa B (NF-κB). Both curcumin, a component spice turmeric, N-acetylcysteine (NAC), an antioxidant, inhibit activation NF-κB inflammatory stimuli, albeit different mechanisms. present study, we tested hypothesis that dietary curcumin or NAC supplementation would unloading-induced activity in thereby protect...
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Fibroblasts are the major mesenchymal cells present within interstitium of lung and a source vascular endothelial growth factor (VEGF), which modulates maintenance pulmonary microvasculature. Prostaglandin E(2) (PGE(2)) acts on set E-prostanoid (EP) receptors that activate multiple signal transduction pathways leading to downstream responses. We investigated modulation by PGE(2) VEGF release human fibroblasts. Human fibroblasts were cultured until reaching 90% confluence in tissue culture...
Inflammation contributes to the development of fibrotic and malignant diseases. We assessed ability inflammatory cytokines modulate endothelial cell survival functions related tissue repair/remodeling. Treatment with interleukin (IL)-1β or tumor necrosis factor (TNF)-α (2 ng/mL) led human pulmonary artery cells becoming spindle-shaped fibroblast-like cells. However, immunoblot DNA microarray showed no change in most mesenchymal markers. In presence IL-1β TNF-α, were resistant apoptosis...
Tumor necrosis factor (TNF)-α can alter tissue repair functions in a variety of cells including endothelial cells. However, the mechanism by which TNF-α mediates these functional changes has not fully been studied. We investigated role mitogen-activated protein kinases (MAPKs) on mediating regulatory effect human pulmonary artery (HPAECs). protected HPAECs from undergoing apoptosis induced serum and growth deprivation, augmented collagen gel contraction, stimulated wound closure. activated...
Alterations in microRNA (miRNA) expression may contribute to COPD pathogenesis. In COPD, lung fibroblast repair functions are altered multiple ways, including extracellular mediator release. Our prior study revealed miR-503 is decreased fibroblasts, although the exact role played by undetermined. The current examined a of cytokine, growth factor and fibronectin production fibroblasts from patients with without COPD. Primary adult were isolated or MiR-503 interleukin (IL)-6, -8, PGE2, HGF,...
Reprogramming somatic cells to induced pluripotent stem (iPSCs) eliminates many epigenetic modifications that characterize differentiated cells. In this study, we tested whether functional differences between chronic obstructive pulmonary disease (COPD) and non-COPD fibroblasts could be reduced utilizing approach. Primary from COPD patients were reprogrammed iPSCs. Reprogrammed iPSCs positive for oct3/4, nanog, sox2, formed embryoid bodies in vitro, teratomas nonobese diabetic/severe...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Abstract Bone marrow embolism (BME) is likely a consequence of fractures in which pulmonary vessels are the most affected. However, some cases BME were reported absence trauma. Thus, traumatic injury might not be necessary for developing BME. This study discusses patients without signs or blunt The discussion addresses various possible mechanisms appearance Options include cancer bone metastasis suggestive cause. Another proposal chemical theory where fats released via lipoprotein lipase...