A5043742217- Optical Coherence Tomography Applications
- Photoacoustic and Ultrasonic Imaging
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Advanced Fluorescence Microscopy Techniques
- Optical Imaging and Spectroscopy Techniques
- Glaucoma and retinal disorders
- Cutaneous Melanoma Detection and Management
- Ophthalmology and Visual Impairment Studies
- Retinal and Macular Surgery
- Nonmelanoma Skin Cancer Studies
- Coronary Interventions and Diagnostics
- Spectroscopy Techniques in Biomedical and Chemical Research
- Spectroscopy and Laser Applications
- Retinal and Optic Conditions
- Infrared Thermography in Medicine
- Non-Invasive Vital Sign Monitoring
- Corneal surgery and disorders
- Ocular and Laser Science Research
- Angiogenesis and VEGF in Cancer
- Ultrasound Imaging and Elastography
- Digital Holography and Microscopy
- Retinal Development and Disorders
- Laser Design and Applications
- Cell Image Analysis Techniques
Physical Sciences (United States)
2015-2024
University of California, Davis
2019
Tulane University
2019
The University of Texas MD Anderson Cancer Center
2019
Memorial Sloan Kettering Cancer Center
2019
Digital Optics Technologies (United States)
2018
New England College of Business
2017
Massachusetts General Hospital
2002-2008
Harvard University
2002-2005
Harvard–MIT Division of Health Sciences and Technology
2004
We demonstrate high-speed, high-sensitivity, high-resolution optical imaging based on frequency-domain interferometry using a rapidly-tuned wavelength-swept laser.We derive and show experimentally that ranging provides superior signal-to-noise ratio compared with conventional time-domain as used in coherence tomography.A high sensitivity of -110 dB was obtained 6 mW source at an axial resolution 13.5 µm A-line rate 15.7 kHz, representing more than order-of-magnitude improvement previous OCT...
To describe the fine structure of fovea in subjects with a history mild retinopathy prematurity (ROP) using adaptive optics-Fourier domain optical coherence tomography (AO-FDOCT).High-speed, high-resolution AO-FDOCT videos were recorded ROP (n = 5; age range, 14-26 years) and control 18-25 years). Custom software was used to extract foveal pit depth volume from three-dimensional (3-D) retinal maps. The thickness layers as function eccentricity measured manually. vasculature parafoveal region...
The <i>Journal of Biomedical Optics</i> (JBO) is a Gold Open Access journal that publishes peer-reviewed papers on the use novel optical systems and techniques for improved health care biomedical research.
A retinal imaging instrument that integrates adaptive optics (AO), scanning laser ophthalmoscopy (SLO), and tracking components was built tested. The system uses a Hartmann-Shack wave-front sensor (HS-WS) MEMS-based deformable mirror (DM) for AO-correction of high-resolution, confocal SLO images. includes wide-field line-scanning ophthalmoscope easy orientation the high-magnification raster. AO corrected ocular aberrations to <0.1 mum RMS error. An active with custom processing board sensed...
The limited tissue sampling of a biopsy can lead to an incomplete assessment basal cell carcinoma (BCC) subtypes and depth. Reflectance confocal microscopy (RCM) combined with optical coherence tomography (OCT) imaging may enable real-time, noninvasive, comprehensive three-dimensional in vivo, which improve the diagnostic accuracy margin BCCs.To determine RCM-OCT device for BCC detection deep assessment.This pilot study was carried out on 85 lesions from 55 patients referred physician...
We present for the first time a full three-dimensional (3-D) reconstruction of absorption images breast from continuous-wave (cw) measurements performed on premenopausal woman. Our 3-D optical clearly reveal large primary tumor as well small secondary in separate location breast. The multiple tumors identified by our imaging have been confirmed subsequent biopsy examination Quantitative information obtained is provided terms location, size, and coefficient tumors.
We present a novel multi-resolution variational framework for vascular optical coherence elastography (OCE). This method exploits prior information about arterial wall biomechanics to produce robust estimates of tissue velocity and strain, reducing the sensitivity conventional tracking methods both noise- strain-induced signal decorrelation. The strain estimation performance this new estimator is demonstrated in simulated OCT image sequences benchtop scanning sample.
We developed a multimodal adaptive optics (AO) retinal imager which is the first to combine high performance AO-corrected scanning laser ophthalmoscopy (SLO) and swept source Fourier domain optical coherence tomography (SSOCT) imaging modes in single compact clinical prototype platform. Such systems are becoming ever more essential vision research expected prove their value for diagnosis of diseases, including glaucoma, diabetic retinopathy (DR), age-related macular degeneration (AMD),...
We present a hand-held implementation and preliminary evaluation of combined optical coherence tomography (OCT) reflectance confocal microscopy (RCM) probe for detecting delineating the margins basal cell carcinomas (BCCs) in human skin vivo. A standard OCT approach (spectrometer-based) with central wavelength 1310 nm 0.11 numerical aperture (NA) was RCM (830-nm 0.9 NA) into common path probe. Cross-sectional images enface are simultaneously displayed, allowing three-dimensional microscopic...
WWe present what is believed to be the first absorption and scattering images of in vitro vivo bones joints from continuous-wave tomographic measurements. Human finger chicken embedded cylindrical media were imaged at multiple transverse planes with Clemson multi-channel diffuse optical imager. Both obtained using our nonlinear, finite element based reconstruction algorithm. This study shows that tomography (DOT) has potential used for detection monitoring bone joint diseases such as...
We present a detailed experimental study concerning quantitative optical property reconstruction of heterogeneous turbid media by use absolute dc data only. performed experiments using tissuelike phantoms in both single-target and multitarget configurations which variations target size contrast with the background were explored. Our results show that scattering absorption images can be reconstructed quantitatively only, whereas it was impossible to obtain such information previously reported...
Scanning laser ophthalmoscopy (SLO) is a powerful imaging tool with specialized applications limited to research and ophthalmology clinics due in part instrument size, cost, complexity. Conversely, low-cost retinal devices have capabilities screening, detection, diagnosis of diseases. To fill the niche between these two, hand-held, nonmydriatic line-scanning ophthalmoscope (LSLO) designed, constructed, tested on normal human subjects. The LSLO has only one moving uses novel optical approach...
Real-time display of processed Fourier domain optical coherence tomography (FDOCT) images is important for applications that require instant feedback image information, example, systems developed rapid screening or image-guided surgery. However, the computational requirements high-speed FDOCT processing usually exceeds capabilities most computers and therefore rates rarely match acquisition devices. We have designed an system, including hardware based upon a field programmable gated array,...
We have developed a dual-beam Fourier domain optical Doppler tomography (FD-ODT) system to image zebrafish (Danio rerio) larvae. Two beams incident on the with fixed angular separation allow absolute blood flow velocity measurement be made regardless of vessel orientation in sagittal plane along which heart and most major vasculature lie. spectrometers simultaneously acquire spectra from two interferometers typical (maximum) line rate 18 (28) kHz. The was calibrated using diluted milk...
Optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO) are complementary imaging modalities, the combination of which can provide clinicians with a wealth information to detect retinal diseases, monitor disease progression, or assess new therapies. Adaptive optics (AO) is tool that enables correction wavefront distortions from ocular aberrations. We have developed multimodal adaptive system (MAOS) for high-resolution multifunctional use in variety research clinical...
A new concept for cancer screening has been preliminarily investigated.A targeting agent loaded with a near-infrared (NIR) dye was topically applied on the tissue to highlight cancer-suspect locations and guide optical coherence tomography (OCT) imaging, which used further investigate morphology at micron scale.A pilot study ApcMin mice performed test this approach.As cancer-targeting agent, poly(epsiloncaprolactone) microparticles (PCLMPs), labeled NIR functionalized an RGD...
A combined high-resolution reflectance confocal microscopy (RCM)/optical coherence tomography (OCT) instrument for assessing skin burn gravity has been built and tested. This instruments allows visualizing intracellular details with submicron resolution in the RCM mode morphological birefringence modifications to depths on order of 1.2 mm OCT mode. Preliminary testing dual modality imaging approach performed volunteers some scars normal thermally-injured Epiderm FTTM constructs. The initial...
The <i>Journal of Biomedical Optics</i> (JBO) is a Gold Open Access journal that publishes peer-reviewed papers on the use novel optical systems and techniques for improved health care biomedical research.
We have developed a compact, multimodal instrument for simultaneous acquisition of en face quasi-confocal fundus images and adaptive-optics (AO) spectral-domain optical coherence tomography (SDOCT) cross-sectional images. The system including all AO SDOCT components occupies 60×60 cm breadboard that can be readily transported clinical applications. component combines Hartmann-Shack wavefront sensor microelectromechanical systems-based deformable mirror to sense correct ocular aberrations at...