A5043479380- Mast cells and histamine
- Asthma and respiratory diseases
- Urticaria and Related Conditions
- IL-33, ST2, and ILC Pathways
- Knee injuries and reconstruction techniques
- Sports injuries and prevention
- Psoriasis: Treatment and Pathogenesis
- COVID-19 Clinical Research Studies
- Neuropeptides and Animal Physiology
- Adipokines, Inflammation, and Metabolic Diseases
- Dermatology and Skin Diseases
- Lower Extremity Biomechanics and Pathologies
- Foot and Ankle Surgery
- Shoulder Injury and Treatment
- Inflammasome and immune disorders
- Eosinophilic Esophagitis
- Cytokine Signaling Pathways and Interactions
- Atherosclerosis and Cardiovascular Diseases
- Tendon Structure and Treatment
- Orthopedic Surgery and Rehabilitation
- Total Knee Arthroplasty Outcomes
- Bone fractures and treatments
- Reproductive System and Pregnancy
- Vitamin C and Antioxidants Research
- Retinoids in leukemia and cellular processes
Università di Camerino
2017-2024
University of Perugia
2012-2021
Azienda Ospedaliera di Perugia
2005-2021
Ospedali Riuniti Marche Nord
2020
Ospedale Santa Maria
2017-2019
COVID-19 (coronavirus disease-19) involves humans as well animals and may cause serious damage to the respiratory tract including lung. This pathogenic virus has been identified in swabs performed on throat nose of patients who suffer from or are suspected disease. When infect upper lower it can mild highly acute syndrome with consequent release pro-inflammatory cytokines, interleukin (IL)-1b IL-6. The binding Toll Like Receptor (TLR) causes pro-IL-1b which is cleaved by caspase-1, followed...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious virus that infects humans and number of animal species causing coronavirus disease-19 (COVID-19), distress which has provoked global pandemic serious health crisis in most countries across our planet. COVID-19 inflammation mediated by IL-1, disease can cause symptoms such as fever, cough, lung inflammation, thrombosis, stroke, renal failure headache, to name few. Strategies inhibit IL-1 are certainly helpful...
SARS-CoV-2, also referred to as CoV-19, is an RNA virus which can cause severe acute respiratory diseases (COVID-19), with serious infection of the lower tract followed by bronchitis, pneumonia and fibrosis. The severity disease depends on efficiency immune system which, if it weak, cannot stem its symptoms. new CoV-19 spreads in population at a rate 0.8-3% more than normal flu mostly affects men, since genes are expressed X chromosome. If would spread higher incidence (over 10%), affect...
SARS-Cov-2 infection causes local and systemic inflammation mediated by pro-inflammatory cytokines COX-2 eicosanoid products with metabolic dysfunction tissue damage that can lead to patient death. These effects are primarily induced IL-1 cytokines, which involved in the elevation of hepatic acute phase proteins fever. has a broad spectrum biological activities participates both innate acquired immunity. In infections, induces gene expression synthesis several cytokines/chemokines...
SARS-CoV-2 virus is an infectious agent commonly found in certain mammalian animal species and today also humans. SARS-CoV-2, can cause a pandemic infection with severe acute lung injury respiratory distress syndrome patients COVID-19, that lead to patient death across all ages. The pathology associated linked over-response of immune cells, including virus-activated macrophages mast cells (MCs). local inflammatory response the occurs after exposure due complex network activated innate...
Mast cells (MCs) are derived from hematopoietic progenitors, mature in vascularized tissues, and participate innate acquired immunity. Neuroinflammation is a highly debated topic the biomedical literature; however, impact of tumor necrosis factor (TNF) IL-33 on MCs brain has not been widely addressed. can be activated by IgE binding to FcεRI, as well different antigens. After activation, mediate various immunological inflammatory responses through TNF IL-33. two receptors: TNFR1, p55...
IL-1 induces a significant number of metabolic and hematological changes. In experimental animals, treatments cause hypotension due to rapid reduction systemic blood pressure, reduced vascular resistance, increased heart rate leukocyte aggregations. causes endothelial dysfunction, the triggering factor which may be different nature including pathogen infection. This includes macrophage intervention protein permeability, can mediated by several factors cytokines arachidonic acid products....
Acute severe respiratory syndrome coronavirus-2 (SARS-CoV-2) caused a global pandemic coronavirus disease 2019 (COVID-19). In humans, SARS-CoV-2 infection leads to acute distress which presents edema, hemorrhage, intra-alveolar fibrin deposition, and vascular changes characterized by thrombus formation, micro-angiopathy thrombosis. These clinical signs are mediated pro-inflammatory cytokines. recent studies it has been noted that COVID-19 can affect patients of all ages, including children...