A5084226420- Medical Image Segmentation Techniques
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Radiomics and Machine Learning in Medical Imaging
- Cerebrovascular and Carotid Artery Diseases
- MRI in cancer diagnosis
- Cardiac Imaging and Diagnostics
- Radiation Dose and Imaging
- AI in cancer detection
- Coronary Interventions and Diagnostics
- Advanced Neuroimaging Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Medical Imaging and Analysis
- Bone health and osteoporosis research
- Anesthesia and Pain Management
- Cardiovascular Health and Disease Prevention
- Computer Graphics and Visualization Techniques
- Advanced Neural Network Applications
- Lung Cancer Diagnosis and Treatment
- Brain Tumor Detection and Classification
- Renal and Vascular Pathologies
- Lanthanide and Transition Metal Complexes
- COVID-19 diagnosis using AI
- Radiology practices and education
KTH Royal Institute of Technology
2016-2025
Karolinska Institutet
1995-2024
Linköping University
2010-2020
Novartis (Sweden)
2019
Image Intelligence (Sweden)
2016
Linköping University Hospital
2003-2015
Örebro County Council
2013-2014
Toshiba (United States)
2010
Brigham and Women's Hospital
2010
Uppsala University Hospital
1992-2004
Generalized nucleus segmentation techniques can contribute greatly to reducing the time develop and validate visual biomarkers for new digital pathology datasets. We summarize results of MoNuSeg 2018 Challenge whose objective was generalizable nuclei in pathology. The challenge an official satellite event MICCAI conference which 32 teams with more than 80 participants from geographically diverse institutes participated. Contestants were given a training set 30 images seven organs annotations...
Knowledge of whole heart anatomy is a prerequisite for many clinical applications. Whole segmentation (WHS), which delineates substructures the heart, can be very valuable modeling and analysis functions heart. However, automating this challenging due to large variation shape, different image qualities data. To achieve goal, an initial set training data generally needed constructing priors or training. Furthermore, it difficult perform comparisons between methods, largely differences in...
Many methods have been proposed for tissue segmentation in brain MRI scans. The multitude of complicates the choice one method above others. We therefore established MRBrainS online evaluation framework evaluating (semi)automatic algorithms that segment gray matter (GM), white (WM), and cerebrospinal fluid (CSF) on 3T scans elderly subjects (65–80 y). Participants apply their to provided data, after which results are evaluated ranked. Full manual segmentations GM, WM, CSF available all used...
Despite a long tradition, conventional anatomy education based on dissection is declining. This study tested new virtual reality (VR) technique for learning contrast injection. The aim was to assess whether students value this three-dimensional (3D) visualization method as tool and what they gain from its use in reaching their anatomical objectives. Several 3D vascular VR models were created using an interactive segmentation the "virtual injection" method. allows users, with relative ease,...
To define and evaluate coronary contrast opacification gradients using prospectively ECG-gated single heart beat 320-detector row angiography (CTA).Thirty-six patients with normal arteries determined by 320 x 0.5-mm detector CTA were retrospectively evaluated customized image postprocessing software to measure Hounsfield Units at 1-mm intervals orthogonal the artery center line. Linear regression correlation between mean distance from ostium (regression slope defined as gradient G(d)), lumen...
Background: Healthcare students have difficulties achieving a conceptual understanding of 3D anatomy and misconceptions about physiological phenomena are persistent hard to address. visualization has improved the possibilities facilitating complex phenomena. A project was carried out in which high quality visualizations using high-resolution CT MR images from clinical research were developed for educational use. Instead standard stacks slices (original or multiplanar reformatted)...
Conventional magnetic resonance imaging (MRI) has relatively long scan times for routine examinations, and the signal intensity of images is related to specific MR scanner settings. Due imperfections automatic optimizations, it impossible compare in terms absolute image intensity. Synthetic MRI, a method generate conventional based on quantification, potentially both decreases examination time enables quantitative measurements.To evaluate synthetic MRI brain clinical setting by assessment...
Real-time 3D Echocardiography (RT3DE) has been proven to be an accurate tool for left ventricular (LV) volume assessment. However, identification of the LV endocardium remains a challenging task, mainly because low tissue/blood contrast images combined with typical artifacts. Several semi and fully automatic algorithms have proposed segmenting in RT3DE data order extract relevant clinical indices, but systematic fair comparison between such methods so far impossible due lack publicly...
Background and purpose Damage to the blood-brain barrier with subsequent contrast enhancement is a hallmark of glioblastoma. Non-enhancing tumor invasion into peritumoral edema is, however, not usually visible on conventional magnetic resonance imaging. New quantitative techniques using relaxometry offer additional information about tissue properties. The aim this study was evaluate longitudinal relaxation R1, transverse R2, proton density in group patients malignant glioma before surgery...
Abstract Understanding Alzheimer’s disease (AD) heterogeneity is important for understanding the underlying pathophysiological mechanisms of AD. However, AD atrophy subtypes may reflect different stages or biologically distinct subtypes. Here we use longitudinal magnetic resonance imaging data (891 participants with dementia, 305 healthy control participants) from four international cohorts, and clustering to estimate differential trajectories age clinical onset. Our findings (in amyloid-β...
PurposeLow-Dose Computed Tomography (LDCT) is the most common imaging modality for lung cancer diagnosis. The presence of nodules in scans does not necessarily portend cancer, as there an intricate relationship between nodule characteristics and cancer. Therefore, benign-malignant pulmonary classification at early detection a crucial step to improve diagnosis prolong patient survival. aim this study propose method predicting malignancy based on deep abstract features.MethodsTo efficiently...
A new infraclavicular brachial plexus block method has the patient supine with an adducted arm. The target is any of three cords behind pectoralis minor muscle. point needle insertion intersection between clavicle and coracoid process. advanced 0 degrees -30 posterior, always strictly in sagittal plane next to process while abutting antero-inferior edge clavicle. We tested using magnetic resonance imaging (MRI) 20 adult volunteers, without inserting a needle. Combining 2 simulated directions...
Tortuosity of an artery can disturb fluid mechanics and cause flow separation, which might in turn promote atherogenesis. This study discusses theoretically several quantitative measures arterial tortuosity curvature two dimensions tests them with computations from digitized femoral arteriograms. When reproducibility, sensitivity to scaling computational procedure, agreement between the were all taken into account, total distance factor considered most suitable measures. Significant...
Purpose: To evaluate the biliary enhancement dynamics of two gadolinium chelates Gd-BOPTA (MultiHance®) and Gd-EOB-DTPA (Primovist®) in normal healthy subjects. Material Methods: Ten volunteers were evaluated with both agents by magnetic resonance (MR) imaging at 1.5T using a breath-hold gradient-echo T1-weighted VIBE sequence. The relative signal intensity (SI) differences between common hepatic duct (CHD) liver parenchyma measured before 10, 20, 30, 40, 130, 240, 300 min after contrast...
This paper introduces a new method for automatic quantification of subcutaneous, visceral and non-visceral internal fat from MR-images acquired using the two point Dixon technique in abdominal region. The includes (1) three dimensional phase unwrapping to provide water images, (2) an image intensity inhomogeneity correction, (3) morphon based registration segmentation tissue. is followed by integration corrected images within different compartments that avoids partial volume effects...
For visual grading experiments, which are an easy and increasingly popular way of studying image quality, hitherto used data analysis methods often inadequate. Visual makes assumptions that not statistically appropriate for ordinal data, characteristic curves difficult to apply in more complex experimental designs. The approach proposed this paper, regression (VGR), consists established statistical technique, logistic regression, applied from single-image image-pair experiments with scores...
Background: A thorough understanding of magnetic resonance (MR) contrast media dynamics makes it possible to choose the optimal for each investigation. Differences in visualizing hepatobiliary function between Gd-BOPTA and Gd-EOB-DTPA have previously been demonstrated, but less has published regarding differences liver vessel visualization. Purpose: To compare parenchymal enhancement (MultiHance) (Primovist). Material Methods: The signal intensity parenchyma, common hepatic artery, middle...
In Multiple Sclerosis (MS) the relationship between disease process in normal-appearing white matter (NAWM) and development of lesions is not well understood. this study we used single voxel proton 'Quantitative Magnetic Resonance Spectroscopy' (qMRS) to characterize NAWM thalamus both atypical 'Clinically Definite MS' (CDMS) patients, MRIneg (N = 15) with very few (two or fewer lesions), typical CDMS MRIpos 20) lesions, comparison healthy control subjects 20). addition, metabolite...
Introduction: Magnetic Resonance Imaging is a sensitive technique for detecting white matter (WM) MS lesions, but the relation with clinical disability low. Because of this, changes in both 'normal appearing matter' (NAWM) and 'diffusely abnormal (DAWM) have been interest recent years. MR techniques, including quantitative magnetic resonance imaging (qMRI) spectroscopy (qMRS), developed order to detect quantify such changes. In this study, qMRI qMRS were used investigate NAWM DAWM typical...
<h3>BACKGROUND AND PURPOSE:</h3> Contrast-enhancing MS lesions are important markers of active inflammation in the diagnostic work-up and disease monitoring with MR imaging. Because intravenous contrast agents involve an expense a potential risk adverse events, it would be desirable to identify without using agent. The purpose this study was evaluate whether pre-contrast injection tissue-relaxation rates proton density lesions, by new quantitative imaging sequence, can lesions. <h3>MATERIALS...
Study Design Cross-sectional study. Background Findings of fat infiltration in cervical spine multifidus, as a sign degenerative morphometric changes due to whiplash injury, need be verified. Objectives To develop method using water/fat magnetic resonance imaging (MRI) investigate and cross-sectional area multifidus muscle individuals with whiplash-associated disorders (WADs) compared healthy controls. Methods Fat the muscles spanning C4 C7 segmental levels were investigated by manual...
The aim of this study was to define the shape variations, including diameters and angles, major coronary artery bifurcations.Computed tomographic angiograms from 300 adults with a zero calcium score no stenoses were segmented for centreline luminal models. A computational atlas constructed enabling automatic quantification 3D lengths tree. diameter (mean±SD) left main 3.5±0.8 mm length 10.5±5.3 mm. bifurcation angle (distal or B) 89±21° cases with, 75±23° those without an intermediate...