A5027110387- Skin and Cellular Biology Research
- Autoimmune Bullous Skin Diseases
- Dermatology and Skin Diseases
- Nail Diseases and Treatments
- Genetic and rare skin diseases.
- Parvovirus B19 Infection Studies
- Contact Dermatitis and Allergies
- Acne and Rosacea Treatments and Effects
- Vascular Malformations and Hemangiomas
- Cancer and Skin Lesions
- Urticaria and Related Conditions
- Dermatological and Skeletal Disorders
- Neonatal skin health care
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Dermatological and COVID-19 studies
- RNA regulation and disease
- Eosinophilic Disorders and Syndromes
- Oral Health Pathology and Treatment
- Tumors and Oncological Cases
- melanin and skin pigmentation
- Vascular Tumors and Angiosarcomas
- Dermatologic Treatments and Research
- Inflammatory Myopathies and Dermatomyositis
- Autoimmune and Inflammatory Disorders
University of Massachusetts Chan Medical School
2016-2025
UMass Memorial Health Care
2009-2016
Statistical Service
2007
Communities In Schools of Orange County
2007
Columbia College - Missouri
2007
Oregon Museum of Science and Industry
2005-2006
Indianapolis Zoo
2006
Providence College
2006
University of Massachusetts Amherst
1996
Boston Children's Hospital
1991-1993
Abstract: Pyogenic granuloma (lobular capillary hemangioma) is a common acquired vascular lesion of the skin and mucous membranes in pediatric age group. This retrospective analysis 178 patients, 17 years younger (mean 6.7 yrs). Forty‐two percent lesions occurred first five life; only 12% appeared infants less than 1 year old. The male:female ratio was 3:2. Most patients (74.2%) had no history trauma or predisposing dermatologic condition. mean lesional size 6.5 mm duration at diagnosis 3.8...
Between 1976 and 1981 Haemophilus influenzae was identified in 16 women with postpartum bacteremia 36 neonates or meningitis. H. also recovered from neonatal genital cultures of 50 additional patients. By counterimmunoelectrophoresis 17% isolates blood cerebrospinal fluid (CSF) were type b. All remaining strains (94% overall) nontypable (NT). Of the NT CSF isolates, 38% belonged to biotype 4. all 4 referred Centers for Disease Control during study, 82% genital, neonatal, maternal origin, a...
One hundred three cases of bacteremia or meningitis due to Haemophilus influenzae in adults were evaluated. Among 96 episodes bacteremia, 60% pneumonia and 15% genital-related infections; 10% had no apparent source infection. Of 42 isolates serotyped routine fashion by slide agglutination, 79% reported as type b. In contrast, 45 from the same interval with confirmed serotyping (usually counterimmunoelectrophoresis), only 29% band 64% nontypable; 26% been misidentified agglutination. The...
Abstract Recessive dystrophic epidermolysis bullosa (RDEB) is a genetic disorder due to pathogenic variants in the COL7A1 gene. In this study we determined association between different categories of and clinical disease severity 236 RDEB patients North America. Published reports or in-silico predictions were used assess impact on type VII collagen (C7) protein function. Three postulated: genotypes that would likely cause low C7 function (splice B/missense, missense/missense), medium...
As coronavirus disease 2019 (COVID-19) cases continue to increase, so do the reported extrapulmonary manifestations of this disease. To date, described dermatologic COVID-19 include pernio-like acral nodules, dengue fever–like petechiae, vesiculobullous eruptions, pityriasis rosea and viral-like exanthems, retiform purpura, livedo reticularis.1 We describe a patient with new-onset, biopsy confirmed sarcoid-like reaction in setting pneumonia postulate role for immunologic hastening recovery.
Hair follicle nevus is a rare benign follicular hamartoma that characterized histologically by the proliferation of vellus hair follicles with peri-follicular fibrous thickening. Clinically, most commonly reported as an asymptomatic papule or nodule on head and neck. Here, we describe unusual presentation presenting atrophic plaque cheek male infant.
ABSTRACT Several cryotherapy techniques are used to treat benign conditions in pediatric dermatology. These include a long‐tipped cotton swab, portable sprayer can (“cryo gun”), and forceps, amongst others. However, all modalities result peri‐procedural pain often emotional distress. We present modification of the swab technique by making wick from rayon‐tipped OB/GYN swab. This may minimize patient distress, while achieving controlled efficacious freeze.
<h3>Importance</h3> Children with epidermolysis bullosa (EB) comprise a rare population high morbidity and mortality. An improved understanding of the clinical trajectory patients EB, including age at time diagnosis major events, is needed to refine best practices improve quality life outcomes for EB. <h3>Objectives</h3> To describe demographics, characteristics, milestone diagnostic events (such as initial esophageal dilation), in EB using Epidermolysis Bullosa Clinical Characterization...
Diaper dermatitis is a common problem in outpatient pediatric office settings. Although most diaper rashes represent form of contact response to irritants the environment, other may be result an allergen diaper. On basis clinical examination results for 5 patients and patch testing 2 patients, we suspect that demonstrated allergic various blue, pink, green dyes diapers. topically administered corticosteroids are useful treatment regimen, preferred area use dye-free diapers avoidance. Patch...
Trimethoprim (TMP) and sulfamethoxazole (SMZ) were studied alone in combination (TMP-SMZ) against 141 nontuberculous mycobacteria; an agar dilution method was used. All strains of Mycobacterium kansasii (8), marinum (16), scrofulaceum (3); 97% (63 65) fortuitum; 27% (3 11)of avium-intracellulare inhibited by ⩽32μg SMZ/ml. In contrast, all 38 isolates chelonei resistant to 32 μg species highly TMP, with minimal inhibitory concentrations (MICs) ⩾64 μg/ml. The MICs TMP-SMZ for these organisms...
Forty-eight clinical strains of Mycobacterium fortuitum and 15 chelonei were evaluated for susceptibility to sulfonamides, including trimethoprim-sulfamethoxazole (TMP-SMZ). Sensitivity tests carried out with use agar dilutions in Mueller-Hinton a plate inoculum 102 cfu. Thirty-six percent the isolates M. jortuitum inhibited by 8 μg sulfonamide/ml, 98% 32 μ/ml. None at these concentrations, but 73% 128 μg/ml, 87% 256 ~g/ml. Both species highly resistant TMP, combination TMP-SMZ (1:20) was no...
Abstract Background Current literature addressing dermatologic conditions associated with Down syndrome is limited, emphasis on rare skin and lack of consensus the incidence more common disorders. Objective We sought to evaluate in patients diagnosed managed by dermatologists. Methods This was a retrospective analysis 101 pediatric adult seen University Massachusetts Dermatology Department between 2008 2018. Results Folliculitis most diagnosis overall (30.7%), followed seborrheic dermatitis...
Pityrosporum folliculitis is a common inflammatory skin disorder that may mimic acne vulgaris. Some adolescents with recalcitrant follicular pustules or papules have and simultaneously. Clinical response dependent on treating both conditions.To demonstrate the similarity in clinical manifestation between vulgaris folliculitis, benefit of potassium hydroxide preparation, appropriate antifungal therapy.We describe 6 female concurrent infection vulgaris.A examination was performed all patients...
Abstract Background/Objectives Patients with epidermolysis bullosa (EB) require care of wounds that are colonized or infected bacteria. A subset EB patients at risk for squamous cell carcinoma, and bacterial‐host interactions have been considered in this risk. The Clinical Characterization Outcomes Database serves as a repository information from multiple centers the United States Canada. Access to resource enabled broad‐scale analysis wound cultures. Methods retrospective 739 cultures 158...
• Two patients with rhabdomyosarcoma presented clinically dermal nodules on the face. The first patient was a 12-month-old girl 2 × 3-cm-diameter red nodule her left cheek that had begun as small papule when she 3 months old and progressively increased in size. second 19-year-old who an enlarging mass right pea-sized three previously. In both cases, biopsies revealed underlying soft tissue extension into overlying dermis. Rhabdomyosarcoma presenting is rare. It usually presents asymptomatic...
Current agar dilution methods for susceptibility testing of Mycobacterium marinum versus the tetracyclines have failed to show in vitro despite good vivo results. We found that were unstable and resulted a fine haze growth several concentrations before complete inhibition was seen. In contrast, aminoglycosides sharp minimal inhibitory concentration endpoints, which generally independent length incubation. The problems with can be lessened by shortening incubation time 5 days redefining as...
Abstract Althouygh Menkes disease has well‐recognized neurologic, developmental, and cutaneous features, the initial presentation may resemble child abuse. We describe a 5‐month‐old boy with multiple fractures indicative of nonaccidental trauma who was ultimately diagnosed disease. Copper deficiency leads to connective tissue abnormalities result in subdural hematomas, wormian bones, cervical spine defects, rib fractures, spurring long bone metaphyses. Several these findings, including be...