A5018150564- Skin and Cellular Biology Research
- Autoimmune Bullous Skin Diseases
- Ocular Oncology and Treatments
- Cutaneous Melanoma Detection and Management
- Dermatological and Skeletal Disorders
- Hereditary Neurological Disorders
- Plant Reproductive Biology
- Iron Metabolism and Disorders
- Pediatric Pain Management Techniques
- Cancer and Skin Lesions
- Botulinum Toxin and Related Neurological Disorders
- Cancer Genomics and Diagnostics
- Erythrocyte Function and Pathophysiology
- Blood properties and coagulation
- Mast cells and histamine
- Porphyrin Metabolism and Disorders
- Connective tissue disorders research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Cincinnati Children's Hospital Medical Center
2020-2023
University of Cincinnati
2023
University of Cincinnati Medical Center
2014-2017
Determine which posterior uveal melanoma (PUM) size classification with three categories has the best prognostic discrimination.Single-institution study of 424 consecutive patients PUM. The tumor's largest basal diameter (LBD), smallest (SBD), and thickness (TH) were estimated by fundus mapping ultrasonography. Tumors assigned to "small," "medium," or "large" defined 11 different classifications (Linear LBD, Rectangular LBD × TH, Cubic SBD Warren Original, Modified, Augsburger, COMS Revised,...
To describe the prevalence, severity, and management of anemia in a cohort children with recessive dystrophic epidermolysis bullosa (RDEB) to highlight use soluble transferrin receptor (sTfR) diagnose iron deficiency this chronic inflammatory state.We studied 114 patients RDEB followed at pediatric hospital-based Epidermolysis Bullosa Center from 2010 2020; data were prospectively tracked comprehensive clinical database that captured all visits, laboratory tests, infusions, transfusions. The...
Epidermolysis bullosa (EB) is a group of rare genetic skin conditions that result in fragility. EB can be quite severe with chronic inflammation and malnutrition impairing growth pubertal development. These factors have potential consequences for skeletal health. We aimed to determine the prevalence delayed puberty low bone mineral density (BMD) age children young adults EB.Electronic medical records (EMR) patients confirmed <30 years at time initial encounter Cincinnati Children's Hospital...
Abstract Background/Objectives To determine whether iron was being enterally absorbed in anemic patients with recessive dystrophic epidermolysis bullosa (RDEB). Methods Anemic RDEB who were refractory or had poor adherence to oral gastrostomy‐given underwent enteral absorption challenges. Subjects given 2 mg/kg of elemental iron. Successful defined as a two‐ threefold increase serum rise above 100 µg/dL. Results Nine 12 challenges did not show increased absorption. Only three the ten...
Epidermolysis bullosa (EB) is a rare group of genetic conditions involving mutations in genes such as COL7A1 that encode structural proteins required to maintain skin integrity. These lead fragility and subsequent nonhealing erosions scarring. Because these are also partially expressed other epithelial mesenchymal tissues, patients with EB may have secondary consequences, malnutrition extracutaneous manifestations the renal system. Those junctional generalized severe recessive dystrophic...
Abstract Background/Objectives The primary objective was to assess pain catastrophizing and functional disability in pediatric patients with epidermolysis bullosa (EB) their parents/guardians. Secondary objectives included examining relationships between catastrophizing, disability, correlations other factors (e.g., age, disease severity, percent of body surface area (BSA) involved). Methods Patients EB ages 8–16 parents/guardians who were English or Spanish speaking completed a one‐time...
Journal of the American Society Nephrology 31(10S):p 702, October 2020. | DOI: 10.1681/ASN.20203110S1702a