A5000926082- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Inflammatory Bowel Disease
- Adolescent and Pediatric Healthcare
- Bacteriophages and microbial interactions
- Pharmaceutical studies and practices
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- Virus-based gene therapy research
- Microscopic Colitis
- Gender Diversity and Inequality
- Cystic Fibrosis Research Advances
- Protein purification and stability
- Autoimmune and Inflammatory Disorders Research
- Childhood Cancer Survivors' Quality of Life
- Advanced Biosensing Techniques and Applications
- Neonatal Respiratory Health Research
- Acute Lymphoblastic Leukemia research
- Family Business Performance and Succession
- Corporate Finance and Governance
- Clinical Nutrition and Gastroenterology
- Congenital gastrointestinal and neural anomalies
- Frailty in Older Adults
- COVID-19 and healthcare impacts
- Health Services Management and Policy
Southampton Children's Hospital
2015-2023
The Christie NHS Foundation Trust
2023
University Hospital Southampton NHS Foundation Trust
2014-2021
Southampton General Hospital
2009-2021
Kingston University
2016-2019
University of Southampton
2014
Outcome data for surgery in paediatric Crohn's disease are limited. We report 10 years' experience at a regional gastroenterology centre.Children undergoing (January 2002-December 2012) were identified from an onsite patient register. Patients followed until transition to adult services. Data obtained medical records and expressed as median (range).Sixty-nine children, aged 13.8 years (6.3-17.0) diagnosis, included. 42 male (61%). Follow-up was 1.8 (27 days-6 years). Surgery diagnosis by 9...
The incidence of paediatric inflammatory bowel disease (IBD) has been increasing over 25 years; however, contemporary trends are not established and the impact COVID-19 on case rates is unclear.Data from Southampton Children's hospital prospective IBD database were retrieved for 2002-2021. Incidence calculated based referral area populations temporal analysed. Disease prevalence those aged <18 years was 2017-2021. Monoclonal prescriptions reported.In total, 1150 patients included (mean age...
The aim of the current exploratory study was to investigate impact on care home staff when working with people dementia at end life and explore how they cope this aspect their work. With UK policy encouraging death in place residence, rather than hospital, more are dying homes.A qualitative approach employed; 20 five English homes were interviewed. Thematic Analysis used analyse data.Care found external demands them difficulties associated interacting sometimes challenging, stressful...
Objective Chronic diseases, such as inflammatory bowel disease (IBD), can impact negatively on education and social development. Examining the of IBD school/college attendance for children young people (CYP) is vital to provide targeted support patients, families schools. Methods We performed a cross-sectional survey determine rates, reasons absence related facilitators or barriers attendance. In subset patients followed up locally, we detailed review hospital data assess healthcare burden....
Paediatric nurses can increase awareness of this condition and reduce the incidence irreversible lung damage, says Claire Barnes
This study provides analysis and insight into the views experiences of 12 top executives FTSE 350 companies about appointing women to their boards, against background growth in number female non-executive directors but executive director appointments showing no progress. Findings showed that idea on boards as is well embedded, yet many barriers increasing numbers remain. Lack robust selection processes, negative search companies, shortage suitably qualified are reported while most...
Crohn's disease is a chronic inflammatory bowel condition that affects more than 115,000 people in the UK. This article focuses on adolescents. Management of this group should address adolescent-specific characteristics and treatment goals. Key elements include optimising growth, pubertal development social functioning, including education. The can affect an individual's mental emotional wellbeing significantly, as well their physical health. As adolescence time great change, additional...
Coeliac disease is a systemic autoimmune condition triggered by ingestion of gluten in genetically susceptible individuals. It affects about 1% children and young people the UK. Treatment coeliac strict adherence to gluten-free diet for life. The health-care team has vital role enabling maintain diet, which essential wellbeing prevention long-term complications. Following diagnosis resolution any symptoms or nutrient deficiencies, with require review assess their health compliance. Children...
s of the 3rd International Symposium on Pediatric Inflammatory Bowel Disease S423 P-079 Comparison quality life among children treated with nutritional and anti-TNF therapies for active Crohn’s disease in North America A.R. Otley1 *, D.Y. Lee2, R.N. Baldassano2, A.M. Griffiths3, C.W. Compher4, L.G. Allenberg2, F.D. Bushman4, G.D. Wu4, J.D. Lewis4. 1IWK Health Centre/Dalhousie University, Halifax, Canada, 2Children’s Hospital Philadelphia, United States America, 3Sick Kids Hospital, Toronto,...
Supplementary Figure 1 from Assessing the Activity of Cediranib, a VEGFR-2/3 Tyrosine Kinase Inhibitor, against VEGFR-1 and Members Structurally Related PDGFR Family
<h3></h3> Routine measurement of infliximab levels and anti-drug antibodies before the 4th dose is recommended by ESPGHAN in paediatric IBD. This proactive approach intended to prompt early optimisation dosing during maintenance phase. In our Children's Hospital we routinely measure trough prior dose. We aimed assess if this practice leads changes treatment post-induction. Patients aged 0−17 years commencing between January 2021 May 2022 who had measured at their were included. Infliximab...
<h3>Aims</h3> To study the provision of paediatric liver services in a regional centre South England <h3>Methods</h3> Children with diseases seen Hepatology clinics over last 5 years were included study. Details demographics, underlying diagnosis, investigations and treatments extracted database. <h3>Results</h3> There are two Southampton; one conjunction supra-regional London other transitional clinic, 3 consultants (supraregional, transitional), dietetic, specialist nursing support...