A5032112646- Parasitic Infections and Diagnostics
- Insects and Parasite Interactions
- Malaria Research and Control
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Dermatological diseases and infestations
- Toxoplasma gondii Research Studies
- Pediatric health and respiratory diseases
- Parasitic Diseases Research and Treatment
- Parasitic infections in humans and animals
- Antifungal resistance and susceptibility
- Parasite Biology and Host Interactions
- HIV/AIDS drug development and treatment
- Zoonotic diseases and public health
- Vector-Borne Animal Diseases
- Travel-related health issues
- Helminth infection and control
- Computational Drug Discovery Methods
- Ocular Infections and Treatments
- Amoebic Infections and Treatments
- Historical, Religious, and Philosophical Studies
- Asthma and respiratory diseases
- Animal Disease Management and Epidemiology
- Pneumonia and Respiratory Infections
- Vector-borne infectious diseases
Université Toulouse III - Paul Sabatier
1993-2024
Université de Toulouse
2010-2023
Hôpital Purpan
1992-2017
Centre Hospitalier Universitaire de Toulouse
2000-2016
Centre National de la Recherche Scientifique
2010-2016
Laboratoire d'Anthropologie Sociale
2006-2014
Hôpital Rangueil
2000-2012
Administración Nacional de Laboratorios e Institutos de Salud
2007
Universidad Nacional de La Pampa
2007
Institut de Veille Sanitaire
1998
Toxocariasis is a helminth zoonosis caused by infection with the larvae of Toxocara spp. ascarid worms. Only two species, canis and cati, are recognised as causative agents human disease. The best choice for serodiagnosis generalised forms toxocariasis, visceral larva migrans (VLM) or covert relies upon initial use TES-ELISA, after which any positive result should subsequently be tested Western blotting (WB). Covert toxocariasis mostly benign infection, so large majority infected subjects...
Visceral larva migrans is apparently an endemic disease among adults in southwest France. Thirty-seven living the Midi-Pyrenees region of France were confirmed as having visceral based on increased specific antibody titer to Toxocara canis detected by enzyme-linked immunosorbent assay (ELISA) and Western blot method. The was characterized clinically weakness, pruritis, rash, difficulty breathing, abdominal pain, pathologically allergic manifestations including eosinophilla serum...
ABSTRACT PCR is now commonly applied to the diagnosis of toxoplasmosis. Although several methods are available, comparative studies few, making it difficult compare performance each technique. We compared sensitivities two real-time assays through a prospective study on fetuses, neonates, and immunocompromised patients ocular The first system targeted widely used B1 gene (GenBank accession number AF179871) while second (RE) more recently described sequence repeated roughly 200 300 times...
Abstract Trioxaquines are dual molecules that contain a trioxane motif linked to an aminoquinoline entity. Among the different compounds of this series, trioxaquine cis‐ 15 (DU1302 c), prepared from α‐terpinene, cheap natural product, showed efficient antimalarial activity in vitro on both sensitive and resistant strains Plasmodium falciparum (IC 50 =5–19 n M ). A stereochemical description stable, nontoxic, non‐genotoxic agent is detailed. Mice infected with P. vinckei were successfully...
We report here a clinical evaluation of the Vitek MS system for rapid fungal identification. A strategy that uses single deposit without prior protein extraction was utilized to save time and money. Clinical isolates from Toulouse University hospital were used evaluate performance compared both routine laboratory techniques Vitek2. The performed well in identification yeasts Aspergillus fungi (93.2% correct identifications).
In La Réunion island (Indian Ocean) a seroepidemiological survey for toxocariasis was carried out among 387 subjects over 15 years old by Western blotting using Toxocara canis excretory-secretory larval antigens; 92.8% of the sera were positive. Statistical study, including logistic regression analysis, showed significant correlation blot results with sex, age, and absence water supply. The final model demonstrated that only last 2 factors multiplicative risk toxocariasis. Sex an independent...
Given the problems encountered in westernized countries with laboratory diagnosis of malaria, namely sensitivity conventional methods and detection mixed infections, a polymerase chain reaction (PCR)-based has been developed routinely used. The PCR used two sets primers to simultaneously detect any infection due genus Plasmodium, or species P. falciparum. results were available within six hours. Five hundred twenty-nine patients tested, whom 136 found positive by PCR, only 104 quantitative...
Cystic fibrosis (CF) patients presenting with persistent carriage of, or sensitization to, Aspergillus fumigatus are often treated antifungal therapies because the presence of fungus is commonly thought to impede lung function, even in absence allergic bronchopulmonary aspergillosis (ABPA). The aim this study was assess Aspergillus-related status modulating forced expiratory volume 1 s (FEV₁) CF patients.From 1995 2007, 251 were evaluated. Demographic data, cystic transmembrane conductance...
For the last four decades, knowledge about human toxocariasis with regard to its epidemiology, pathophysiology, clinical spectrum, and imaging or laboratory diagnosis has substantially progressed. Knowledge specific therapy anthelmintics lagged behind. To date, only drugs are registered for use, their efficacy rarely been assessed in prospective controlled trials. It is likely that repurposing of potent from veterinary medicine will improve this situation. Due wide availability a lack major...
SUMMARY An open randomized study was carried out to assess the efficacy of diethylcarbamazine (DEC) and mebendazole (MBZ) across, respectively, 39 41 patients, all exhibiting clinical biological features evocative toxocariasis, together with a positive immunodiagnosis by Western blot using Toxocara larvae excretory-secretory antigens. Clinical impact disease quantified score system (20 parameters). Post-treatment follow-up used also results from eosinophil counts total specific anti- IgE...
Infection with Toxocara canis is a common world-wide human helminthiasis, which rarely elicits central nervous system (CNS) impairment. A case-control study to investigate this discrepancy was carried out, in the cases were 27 adult neurological inpatients for whom definite aetiological diagnosis lacking, and positive immunodiagnosis of toxocariasis had been obtained, both cerebrospinal fluid (CSF) serum. Two control groups used. Controls other diseases who no evidence T. infection CNS....
In order to complete the immunodiagnosis of human toxocaral disease, an immunoenzymatic assay with excretory-secretory antigens from Toxocara canis larvae was developed for detection specific immunoglobulin E (sIgE enzyme-linked immunosorbent [ELISA]). The specificity evaluated in patients presenting various allergic or helminthic diseases. sensitivity assessed exhibiting clinical and biological symptoms indicative toxocariasis, serodiagnosis which made by Western blot (WB; immunoblot)...
We investigated the sero-prevalence of toxocariasis among healthy Korean adults in 1999. A total 314 sera from normal inhabitants Whachon-gun, Gangwon-do, Korea was examined for specific antibody levels against excretory-secretory products second stage larvae Toxocara (TES). The presence cross-reactions with other helminthiases such as cysticercosis, paragonimiasis, sparganosis or clonorchiasis also checked by IgG ELISA. Sera showing positive reaction TES were tested immunoblot and IgE Out...
Abstract Background Regular monitoring of the levels anti-malarial resistance Plasmodium falciparum is an essential policy to adapt therapy and improve malaria control. This can be facilitated by using molecular tools, which are easier implement than classical determination phenotype. In Cameroon, chloroquine (CQ), previously first-line for uncomplicated was officially withdrawn in 2002 replaced initially amodiaquine (AQ) monotherapy. Then, artemisinin-based combination (ACT), notably...
We report 5 cases of ocular toxocariasis in Korean adults complaining visual impairment along with floating or bubbling sensation. Fundoscopic examination revealed a retinal detachment exudate 4 cases. They all showed typical reaction by ELISA and immunoblot against Toxocra excretory-secretory antigen. One case high level anti-Toxocara IgE antibodies (34,000 Toxocara units/L) as well increased serum total the specific for 3 inhalant antigens, suggesting that was associated an atopic status....
Treatment of Scedosporium apiospermum mycetoma usually requires limb amputation. A 49-year-old woman, from Ivory Coast, was diagnosed with Madura foot in 1995. She failed to respond several treatments including itraconazole, fluconazole and co-trimoxazole, refused In December 2002 she admitted hospital France a painful, swollen right leg foot. had no fever C-reactive protein 120 mg/l. Magnetic resonance imaging (MRI) confirmed the destruction tarsus bones tibia extension. Voriconazole (400...
Anthelmintics are commonly used in tropical areas, but also prescribed Western countries with other climates. However, pharmacoepidemiologic studies of these drugs rare.To investigate adverse drug reactions (ADRs) due to anthelmintics.All spontaneous reports ADRs associated albendazole, diethylcarbamazine, flubendazole, ivermectin, mebendazole, niclosamide, praziquantel, pyrantel pamoate, and thiabendazole were identified the French Pharmacovigilance Database from January 1, 1985, August 31,...