A5017092232- Malaria Research and Control
- Mosquito-borne diseases and control
- Drug-Induced Hepatotoxicity and Protection
- Parasites and Host Interactions
- HIV/AIDS Research and Interventions
- Virology and Viral Diseases
- SARS-CoV-2 and COVID-19 Research
- HIV, Drug Use, Sexual Risk
- Animal Virus Infections Studies
- COVID-19 Clinical Research Studies
- Computational Drug Discovery Methods
- Respiratory viral infections research
- COVID-19 epidemiological studies
- Hepatitis C virus research
- Vaccine Coverage and Hesitancy
- Digital Imaging for Blood Diseases
- Hemoglobinopathies and Related Disorders
- Sex work and related issues
- Poxvirus research and outbreaks
- Viral gastroenteritis research and epidemiology
- Immune responses and vaccinations
- Syphilis Diagnosis and Treatment
- Bacterial Infections and Vaccines
- SARS-CoV-2 detection and testing
- Hepatitis Viruses Studies and Epidemiology
Marien Ngouabi University
2013-2025
Laboratoire National de Santé Publique du Congo
2017-2025
Administración Nacional de Laboratorios e Institutos de Salud
2022
Laboratoire National de Santé
2019-2022
Fondation Congolaise Pour La Recherche Médicale
2011-2014
Laboratoire de Chimie de Coordination
2012
Université de Toulouse
2012
Institut National Polytechnique de Toulouse
2012
Université Toulouse III - Paul Sabatier
2012
Centre National de la Recherche Scientifique
2012
Abstract Background The characterization of malaria parasite populations circulating in an area is part site characterization, as a basis for evaluating the impact interventions on genetic diversity, species, and multiplicity infection. present study was aimed at analysing diversity Plasmodium falciparum merozoite surface proteins 1 2 (MSP-1 MSP-2) to determine infection clinical isolates collected from children living Southern district Brazzaville Republic Congo. Methods A total 125...
Abstract The first confirmed case of COVID-19 was detected in the Republic Congo March 2020. Several control measures were implemented during pandemic period. As a result, number reported cases decreased significantly, leading to gradual lifting barrier and declaration end outbreak on 14 October 2022. present study aimed determine post-pandemic prevalence SARS-CoV-2 referral hospitals Talangaï (HRT) Makélékélé (HRM) Brazzaville between 2022 April 2023. Nasopharyngeal samples collected from...
Chloroquine resistance (CR) decreased after the removal of chloroquine from national treatment guidelines in Malawi, Kenia and Tanzania. In this investigation prevalence (CQR) conferring mutant pfcrt allele its associated chromosomal haplotype were determined before change Gabonese (CQ) to artesunate plus amodiaquine (AQ) 2003. The wild type was assessed 144 isolates years 2005 - 07 by PCR fragment restriction digest direct sequencing. For analysis regions flanking locus, microsatellite done...
Abstract Background Regular monitoring of the levels anti-malarial resistance Plasmodium falciparum is an essential policy to adapt therapy and improve malaria control. This can be facilitated by using molecular tools, which are easier implement than classical determination phenotype. In Cameroon, chloroquine (CQ), previously first-line for uncomplicated was officially withdrawn in 2002 replaced initially amodiaquine (AQ) monotherapy. Then, artemisinin-based combination (ACT), notably...
In the Republic of Congo, artemisinin-based combinations have been recommended for treatment uncomplicated malaria since 2006. However, emergence resistant parasites again these in Southeast Asia is a threat control this disease, especially sub-Saharan Africa where weight disease important. Indeed, polymorphisms Plasmodium falciparum K13-propeller gene involved variations drug sensitivity to combinations. The aim current study determine prevalence mutations isolates collected three health...
Molecular characterization of malaria parasites from different localities is important to improve understanding acquisition natural immunity Plasmodium falciparum, assist in identifying the most appropriate strategies for control and evaluate impact interventions. This study aimed determine genetic diversity multiplicity infection falciparum isolates Pointe-Noire, Republic Congo.Plasmodium were collected 71 children with uncomplicated malaria; enrolled into evaluating therapeutic efficacy...
Summary In malaria-endemic regions, pregnant women are more susceptible to malarial infections than non-pregnant women. The main objective of this study, which was conducted in the malaria hyperendemic town Lambaréné (Gabon, Central Africa), characterize Plasmodium falciparum peripheral, placental and cord blood from different gravidities with submicroscopic infections. Using P. merozoite surface protein 2 (MSP 2)* gene as a polymorphic marker polymerase chain reactions, we analysed genetic...
Abstract Background In order to prepare the field site for future interventions, prevalence of asymptomatic Plasmodium falciparum infection was evaluated in a cohort children living Brazzaville. merozoite surface protein 2 gene ( msp 2) used characterize genetic diversity and multiplicity infection. The mutant P. chloroquine resistance transporter pfcrt ) allele isolates also determined. Methods Between April June 2010, 313 below 10 years age enrolled malaria surveillance were screened using...
Congo-Brazzaville adopted artemisinin-based combination therapy (ACT) in 2006. Artesunate-amodiaquine (AS + AQ) and artemether-lumefantrine are the first-line second-line anti-malarial drugs to treat uncomplicated Plasmodium falciparum malaria, respectively. The baseline efficacy of AS AQ was evaluated from February August 2005 patients living Brazzaville, capital city Republic Congo. One hundred ninety-seven (96 ≤5 years old 101 >5 old, including adults) were recruited a non-randomized...
BackgroundTo extend our previous findings showing an imbalanced distribution of immunoglobulin G2 (IgG2) antibodies to Plasmodium falciparum merozoite surface protein 2 (MSP2) and a higher frequency infection with multiple P. strains in Gabonese children sickle cell trait (hemoglobin AS), human Fcγ receptor (FcγR) IIa (CD32) polymorphism the rate vitro invasion red blood cells (RBCs) from subjects either hemoglobin AA or AS by were investigated MethodsFcγRIIa mutation at amino acid position...
Female Sex Workers (FSWs) are considered to be at high risk for transmission of Sexually Transmitted Infections (STIs) and defined as a priority the national HIV/AIDS response in Republic Congo (RoC). However, no data available regarding STIs this group. This study aimed determine prevalences HIV, syphilis hepatitis B C among FSWs five cities country.A cross-sectional was conducted from November 2nd 2011 May 15th 2012. Participants were recruited Brazzaville, Pointe-Noire, Dolisie, Nkayi...
Introduction: HIV and syphilis during pregnancy remain a public health concern especially in developing countries. Pregnant women attending antenatal clinics sites for the first time between September December 2011 who accepted to participate study were enrolled. The objective was estimate infection rate this population.
In the Republic of Congo, hot temperature and seasons distortions observed may impact development malaria parasites. We investigate variation cases, parasite density multiplicity Plasmodium falciparum infection throughout year in Brazzaville.From May 2015 to 2016, suspected patients with uncomplicated were enrolled at Hôpital de Mfilou, CSI « Maman Mboualé», Laboratoire National Santé Publique. For each patient, thick blood was examined calculated. After DNA isolation, MSP1 MSP2 genes...
In this work, we investigated the genetic diversity of HIV-1 and presence mutations conferring antiretroviral drug resistance in 50 drug-naïve infected persons Republic Congo (RoC). Samples were obtained before large-scale access to HAART 2002 2004. To assess recombination, sequencing pol gene encoding a protease partial reverse transcriptase was performed analyzed with updated references, including newly characterized CRFs. The assessment conducted according WHO protocol. Among samples for...
Abstract Background In the Republic in Congo, national algorithm for diagnosis of pulmonary tuberculosis (TB) relies on Ziehl-Neelsen (ZN) sputum smear microscopy, chest X-ray radiography (CXR) and clinical symptoms. Microscopy positive TB (MPT+) is defined as symptoms a ZN smear. negative (MPT-) TB, but CXR changes consistent with TB. The present cross-sectional study was designed to determine prevalence MPT individuals among HIV presenting an ambulatory treatment center (CTA) Brazzaville....
Background . In Republic of Congo, malaria diagnosis still widely relies on microscopy. We aimed to evaluate the performance routine microscopy for at three different health centers in Brazzaville. Methods A total 259, 416, and 131 patients with clinical signs uncomplicated were enrolled Hôpital de Mfilou, Centre Santé Intégré “Maman Mboualé,” Laboratoire National Publique, respectively. Two thick blood smears prepared each patient, first being examined by microscopists second expert....
Measles is a highly infectious, vaccine-preventable viral disease. Often forgotten, it potentially fatal. Its main symptoms are: fever, cough, conjunctivitis, rhinitis and skin rash. Serological diagnoses by ELISA test based on the detection of anti-measles virus immunoglobulins M G (IgM IgG), are used respectively for confirmation suspected cases notified means clinical signs disease in health structures twelve departments Republic Congo involved epidemiological surveillance disease,...
In Africa, measles epidemics are frequently reported, despite numerous preventive measures, such as vaccination, which targets children under 5 years of age. Unfortunately, the Republic Congo is not an exception to this major health concern. Indeed, many cases reported annually. Here, we provide overview epidemiological characteristics laboratory‐confirmed from January 2019 October 2022 well risk factors associated with occurrence outbreak. Samples suspected were collected across country and...
Following the emergence of SARS-CoV-2, cases pets infected with variants circulating among humans were reported. In order to evaluate occurrence SARS-CoV-2 circulation in Republic Congo, we conducted a ten-month study dogs and cats living COVID-19-positive households Brazzaville neighboring localities. Real-time PCR Luminex platform used detect RNA antibodies RBD S proteins, respectively. Our results show for first time simultaneous several including viruses from clades 20A 20H putative...