A5061172065- HIV Research and Treatment
- Viral Infections and Vectors
- HIV/AIDS Research and Interventions
- Viral Infections and Outbreaks Research
- Mosquito-borne diseases and control
- Animal Virus Infections Studies
- Bone Tissue Engineering Materials
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- Agriculture and Rural Development Research
- Aging, Elder Care, and Social Issues
- French Urban and Social Studies
- Cytomegalovirus and herpesvirus research
- Viral gastroenteritis research and epidemiology
- Herpesvirus Infections and Treatments
- HIV/AIDS drug development and treatment
- Plant Virus Research Studies
- Virus-based gene therapy research
- Multiple Sclerosis Research Studies
- Malaria Research and Control
- Insect and Arachnid Ecology and Behavior
- 3D Printing in Biomedical Research
- Dental Implant Techniques and Outcomes
- Mesenchymal stem cell research
- Hepatitis C virus research
Institut de Recherche pour le Développement
2015-2025
Centre National de la Recherche Scientifique
2014-2025
Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle
2015-2025
Université de Montpellier
2014-2025
Agropolis International
2011-2024
Marien Ngouabi University
2023
University of British Columbia
2018-2022
Vancouver Coastal Health
2022
Laboratoire de Biologie, Bioingéniérie et Bioimagerie ostéoarticulaire
2012-2018
Université Paris Cité
2011-2018
Epidemiologic data suggest that infection with herpes simplex virus type 2 (HSV-2) is associated increased genital shedding of human immunodeficiency 1 (HIV-1) RNA and HIV-1 transmissibility.
Ebolavirus species Zaire (ZEBOV) causes highly lethal hemorrhagic fever, resulting in the death of 90% patients within days. Most information on immune responses to ZEBOV comes from vitro studies and animal models. The paucity data human this virus is mainly due fact that most outbreaks occur remote areas. Published setting, based small numbers samples limited panels immunological markers, have given somewhat different results.Here, we studied a unique collection 56 blood 42 nonsurvivors 14...
Chikungunya virus (CHIKV) is a worldwide emerging pathogen. In humans it causes syndrome characterized by high fever, polyarthritis, and in some cases lethal encephalitis. Growing evidence indicates that the innate immune response plays role controlling CHIKV infection. We show here induces major but transient modifications NK-cell phenotype function soon after onset of acute report clonal expansion NK cells coexpress CD94/NKG2C inhibitory receptors for HLA-C1 alleles are correlated with...
In a survey of household cats and dogs laboratory-confirmed COVID-19 patients, we found high seroprevalence SARS-CoV-2 antibodies, ranging from 21% to 53%, depending on the positivity criteria chosen. Seropositivity was significantly greater among pets COVID-19+ households compared those with owners unknown status. Our results highlight potential role in spread epidemic.
Abstract An outbreak of febrile illness occurred in Gabon 2007, with 20,000 suspected cases. Chikungunya or dengue-2 virus infections were identified 321 patients; 8 patients had documented co-infections. Aedes albopictus was as the principal vector for transmission both viruses.
Rapidly spreading to new regions, including the islands of Indian Ocean, Central Africa, and Europe, Chikungunya fever is becoming a major problem public health. Unlike other members alphavirus genus, immune responses virus (CHIKV) have been poorly investigated.We conducted large ex vivo multiplex study 50 cytokine, chemokine, growth factor plasma profiles in 69 acutely infected patients from Gabonese outbreak 2007. We also assessed phenotypic T lymphocyte during human acute CHIKV...
Background. Chikungunya virus (CHIKV) and Dengue serotype 2 (DENV-2) were recently introduced in central Africa, along with Aedes albopictus. Simultaneous outbreaks of CHIKV DENV-2 have subsequently occurred, Cameroon 2006 Gabon 2007.
To better understand Zaire ebolavirus (ZEBOV) circulation and transmission to humans, we conducted a large serological survey of rural populations in Gabon, country characterized by both epidemic non regions. The lasted three years covered 4,349 individuals from 220 randomly selected villages, representing 10.7% all villages Gabon. Using sensitive specific ELISA method, found ZEBOV-specific IgG seroprevalence 15.3% overall, the highest ever reported. rate was significantly higher forested...
Significance Sickle cell disease (SCD) is a major cause of death for young children in Africa, which the World Health Organization has declared public health priority. It increasingly spreading outside Africa because population migrations, and, thus, it will become near future global concern. therefore important to understand how this genetic disorder maintained human populations. Although association between Plasmodium falciparum malaria and SCD well known, strength far from known. Using an...
The present study aimed at elucidating the effect of local pH in extracellular microenvironment tissue-engineered (TE) constructs on bone cell functions pertinent to new tissue formation. To this aim, we evaluated osteogenicity process associated with prepared from human Bone marrow-derived mesenchymal stem cells (hBMSC) combined 45S5 bioactive glass (BG), a material that induces alkalinization external medium. measured cell-containing BG was around 8.0, is, 0.5 U more alkaline than two...
Domestic pets can contract severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; however, it is unknown whether the UK B.1.1.7 variant more easily infect certain animal species or increase possibility of human-to-animal transmission.This a descriptive case series reporting SARS-CoV-2 infections in group dogs and cats with suspected myocarditis.The study describes infection domestic by variant. Two one dog were positive to PCR on rectal swab, two found have antibodies 2-6...
Abstract While secretory Abs have been extensively explored in human breast milk, the existence, features, and functions of B lymphocytes remain largely unexplored this compartment. We analyzed milk blood from 21 lactating women, including 12 HIV-1-infected mothers. Breast cells displayed a phenotype class-switched memory cells, with few IgD+ naive cells. observed that bore unique profile adhesion molecules (CD44+, CD62L−, α4β7+/−, α4β1+). Higher percentages activated (CD38+), large-sized...
Plasmodium vivax is considered to be absent from Central and West Africa because of the protective effect Duffy negativity. However, there are reports persons returning these areas infected with this parasite observations suggesting existence transmission. Among possible explanations for apparent paradox, a zoonotic reservoir has been proposed. May great apes reservoir? We analyze mitochondrial nuclear genetic diversity P. parasites isolated in compare it travelers regions Africa, as well...
Ebola virus (EBOV) is a highly virulent human pathogen. Recovery of infected patients associated with efficient EBOV-specific immunoglobulin G (IgG) responses, whereas fatal outcome defective humoral immunity. As B-cell epitopes on EBOV are poorly defined, we sought to identify specific in four proteins (Glycoprotein (GP), Nucleoprotein (NP), and matrix Viral Protein (VP)40 VP35). For the first time, tested IgG+ sera from asymptomatic individuals symptomatic Gabonese survivors, collected...
Abstract Domestic pets can contract SARS-CoV-2 infection but, based on the limited information available to date, it is unknown whether new British B.1.1.7 variant more easily infect certain animal species or increase possibility of human-to-animal transmission. In this study, we report first cases domestic cats and dogs by diagnosed at a specialist veterinary hospital in South-East England. Furthermore, discovered that many owners handlers these had developed Covid-19 respiratory symptoms...
Antibodies to human immunodeficiency virus (HIV) of the IgA, IgG, and IgM isotypes high levels HIV suppressive β-chemokine RANTES (regulated on activation, normally T cell expressed secreted) were found in cervicovaginal secretions (CVSs) 7.5% 342 multiply repeatedly exposed African HIV-seronegative female sex workers. The antibodies are part a local compartmentalized secretory immune response HIV, since they present vaginal fluids that free contaminating semen. Cervicovaginal showed...
Zaïre ebolavirus (ZEBOV) infection rapidly outruns the host's immunity and leads to death within a week. Fatal cases have been associated with an aberrant innate, proinflammatory immune response followed by suppressed adaptive leading rapid depletion of peripheral NK cells lymphocytes. A critical role for has suggested but not elucidated. In this genetic study, we investigated association KIR genotype disease outcome comparing genotypes Gabonese control population, IgG+ contacts, survivors,...
Local tissue ischemia is a prime cause responsible for the massive cell death in tissue-engineered (TE) constructs observed postimplantation. To assess impact of on implanted human multipotent stromal cells (hMSCs), which have great potential repairing damaged tissues, we hereby investigated vivo temporal and spatial fate Luc-GFP-labeled MSCs within fibrin gel/coral scaffolds subcutaneously nude mice. In bioluminescence imaging monitoring histological analyses tested confirmed irremediable...
Background Chikungunya virus (CHIKV) has caused multiple outbreaks in tropical and temperate areas worldwide, but the clinical biological features of this disease are poorly described, particularly Africa. We report a prospective study during an outbreak that occurred Franceville, Gabon 2010. Methodology/Principal Findings collected, suspect cases (individuals presenting with at least one following symptoms or signs: fever, arthralgias, myalgias, headaches, rash, fatigue, nausea, vomiting,...
Dengue is now a leading cause of morbidity and mortality throughout the tropics. We conducted first ex vivo study dengue fever (DF) in African patients infected during Gabonese virus 2 (DENV-2) outbreak 2007, order to investigate cytokine production, including antiviral IFN-α, reported be potent inhibitor DENV replication vitro. Levels 50 cytokines, chemokines growth factors were measured plasma from 36 with DENV-2 infection, uninfected controls, using Luminex multiplex technology. The...
The effects of mechanical stimuli to which cells are exposed in vivo are, at best, incompletely understood; this respect, gene-level information regarding cell functions pertinent new tissue formation is special interest and importance applications such as engineering regeneration.Motivated by need, the present study investigated early responses human mesenchymal stem (hMSCs) intermittent shear stress (ISS) cyclic hydrostatic pressure (CHP) simulating some aspects biological milieu these...
We tested 144 pet rabbits sampled in France between November 2020 and June 2021 for antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by microsphere immunoassay. reported the first evidence of a natural SARS-CoV-2 infection with low observed seroprevalence 0.7% 1.4%.
The protozoan Toxoplasma gondii is a ubiquitous and highly prevalent parasite that can theoretically infect all warm-blooded vertebrates. In humans, toxoplasmosis causes infections in both immunodeficient immunocompetent patients, congenital toxoplasmosis, ocular lesions. These manifestations have different degrees of severity. Clinical severity determined by multiple factors, including the genotype T. strain involved infection. exhibits remarkable genetic diversity, which varies according...