A5019986003- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Microfluidic and Capillary Electrophoresis Applications
- Medication Adherence and Compliance
- Mobile Health and mHealth Applications
- Digital Mental Health Interventions
- Asthma and respiratory diseases
- Metabolomics and Mass Spectrometry Studies
- Social Media in Health Education
- Innovative Microfluidic and Catalytic Techniques Innovation
- Ethics in Clinical Research
- Cardiac Health and Mental Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Health, Environment, Cognitive Aging
- Organoselenium and organotellurium chemistry
- Biosensors and Analytical Detection
- Advanced Chemical Sensor Technologies
- Organic Chemistry Cycloaddition Reactions
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes Management and Research
- Pharmaceutical Economics and Policy
- Pharmaceutical Practices and Patient Outcomes
- Analytical chemistry methods development
- Cerebral Palsy and Movement Disorders
- Molecular spectroscopy and chirality
AstraZeneca (Sweden)
2006-2024
AstraZeneca (Brazil)
2021
University of Zagreb
2018
Beijing Anzhen Hospital
2016
Capital Medical University
2016
Lund University
2002-2008
Abstract This study aimed to validate a wearable device’s walking speed estimation pipeline, considering complexity, speed, and bout duration. The goal was provide recommendations on the use of devices for real-world mobility analysis. Participants with Parkinson’s Disease, Multiple Sclerosis, Proximal Femoral Fracture, Chronic Obstructive Pulmonary Congestive Heart Failure, healthy older adults (n = 97) were monitored in laboratory (2.5 h), using lower back device. Two pipelines validated...
was treated unevenfully with a drug-eluting balloon angioplasty.Three severely stenosed external carotid arteries (ECAs) occluded at CAS; ECA patency rate 97.0% post CAS and 30 days, 97% 12 months.At months, in-stent velocities were normal (PSV 0.81±0.3;EDV 0.21±0.3m/s). Conclusions:The PARADIGM study 12-month clinical DUS data are consistent healing sustained safety cerebral embolism prevention efficacy of the CGuard™ stent used routinely for stroke in symptomatic increased-stroke-risk...
A novel technique that uses polymer nanoparticles as pseudostationary phase in capillary electrochromatography with electrospray ionization mass spectrometry detection is described. continuous full filling which the were suspended entire electrolyte volume well a conventional partial presented. No entered spectrometer, was fitted an orthogonal interface, despite flow of into interface. Nanoparticles (average diameter 160 nm) prepared from methacrylic acid, methyl methacrylate, and...
We present a new method for separation of enantiomers with high-field asymmetric waveform ion mobility spectrometry (FAIMS), coupled to mass spectrometric detection. Upon addition an appropriate chiral reference compound the analyte solution and subsequent ionization by electrospray ionization, formed diastereomeric complexes, which were potentially separable FAIMS. The methodology being developed is intended be general, but here amino acid analytes are specifically considered. In examples...
Highly efficient reversed-phase capillary electrochromatography (CEC) separations (plate numbers up to 700 000/m), with electrospray ionization mass spectrometry detection were achieved utilizing novel dextran-coated polymer nanoparticles as a pseudostationary phase. A continuous full filling (CFF) technique in which are continuously introduced into the was employed for separation of neutral analytes (dialkyl phthalates), an orthogonal interface prevent from entering spectrometer. CFF-CEC...
Abstract Direct coupling of micellar electrokinetic chromatography (MEKC) to mass spectrometry (MS) without employing partial filling is considered be a challenge. One way solving the problem would use an MS‐compatible surfactant. In present study, applicability series surfactants (sodium dodecyl sulfate (SDS), lauric acid, cholic acid and perfluorated carboxylic acids) have been investigated both in terms separation performance MS compatibility. It was found that MEKC system based on...
Capillary electrophoresis (CE) has been combined with atmospheric pressure photoionization (APPI) and electrospray ionization (ESI) for mass spectrometric (MS) detection. Separation conditions using potassium phosphate buffer ammonium formate have compared analysis of eleven pharmaceutical bases. The results showed improvements in separation efficiency peak symmetry when was used. low flow CE may enable utilization these advances MS Compared ESI, the APPI technique provided a cluster-free...
Recently, we introduced a new approach to chiral separation and analysis of amino acids by complexation electrospray high-field asymmetric waveform ion mobility spectrometry coupled mass (ESI-FAIMS-MS). In the present work, extended this drug compound terbutaline. Terbutaline enantiomers were complexed with metal ions an acid form diastereomeric complexes type [MII(l-Ref)2((+)/(−)-A)-H]+, where MII is divalent ion, L-Ref in its L-form, A terbutaline analyte. When reference suitably chosen,...
Abstract A chemometrics approach has been used for evaluating the effect of four experimental parameters when coupling capillary electrophoresis (CE) to electrospray ionization‐mass spectrometry (ESI‐MS). Electrospray voltage, sheath‐liquid flow rate, nebulizing gas and spray needle position in respect MS orifice were varied according a full factorial design. In addition main effects, two interaction effects could be identified as significant measuring peak intensity analytes, from sample...
Background: The individualized PREdiction of DIsease Control using digital sensor Technology (iPREDICT) program was developed for asthma management technology. Devices were integrated into daily lives patients to establish a predictive model control by measuring changes from baseline health status with minimal device burden. Objectives: To disease characteristics the study participants, detect associated events, and evaluate algorithms capable identifying triggers predicting data. Patient...
Structure analysis of partially depolymerized methyl cellulose was performed by nanoelectrospray ionization tandem mass spectrometry (nano-ESI-MS/MS) and matrix-assisted laser desorption/ionization (MALDI-MS/MS). Dimethylamine (DMA) used for the first time as a reducing end derivatization reagent oligosaccharides. This is an attractive since it could be easily removed from reaction mixture. Most important also introduces basic functional group that increased sensitivity in both MALDI...
Abstract In this study, peak‐broadening effects caused by nebulizing gas flow and lack of temperature control have been investigated for separation capillaries with three different inner diameters. The study was performed serial UV/ESI‐MS detection in an effort to distinguish between peak broadening arising the ion source. found significantly affect both migration time efficiency when using 50 75 µm id. If is on during injection, injection volume increases such extent that significant...
This study evaluated whether patient support, administered via an electronic device-based app, increased adherence to treatment and lifestyle changes in patients with acute coronary syndrome (ACS) treated ticagrelor routine clinical practice.Patients (aged ≥ 18 years) diagnosed ACS co-administered low-dose acetylsalicylic acid were randomized into active group (with support tool app for medication intake reminders motivational messages) a control (without app), observed 48 weeks...
Abstract A novel smartphone‐based patient support tool was developed to increase the adherence antiplatelet therapy and lifestyle changes in patients after coronary angioplasty for acute syndrome (ACS). The eMocial study ( ClinicalTrials.gov Identifier: NCT02615704) investigates whether an electronic will improve comedication ACS patients. primary hypothesis of this trial is that can (primary endpoint) thereby supporting positive (secondary endpoints). Patients hospitalized with (ST...
The iPREDICT program aimed to develop an integrated digital health solution capable of continuous data streaming, predicting changes in asthma control, and enabling early intervention.